DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gk2 and SHPK

DIOPT Version :9

Sequence 1:	NP_001286904.1	Gene:	Gk2 / 38221	FlyBaseID:	FBgn0035266	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_037408.2	Gene:	SHPK / 23729	HGNCID:	1492	Length:	478	Species:	Homo sapiens

Alignment Length:	529	Identity:	111/529 - (20%)
Similarity:	192/529 - (36%)	Gaps:	157/529 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 IDEGTKTI-------------GFSIYTTPDFKEIAAHRVELSVITPQDGWYEQDPLEMMASINKC 87
            ||.||.::             ||::..:......|...||.:|..||.  .|||...::.::::|
Human    10 IDLGTTSVKAALLRAAPDDPSGFAVLASCARAARAEAAVESAVAGPQG--REQDVSRILQALHEC 72

  Fly    88 AEEAIKQLPEQGFSASDIVTVGITNQRETTIVWDAVTG--------KPLY------NALLWKDIR 138
                :..||..  ....:|.:|::.|....:.|....|        .|::      :.:.|:|.|
Human    73 ----LAALPRP--QLRSVVGIGVSGQMHGVVFWKTGQGCEWTEGGITPVFEPRAVSHLVTWQDGR 131

  Fly   139 TSTTVEQIVAKVQDPNHFRSSTGLPISTYFSALKIRWLRDNVPEVRQAIRERRCKAGTVDSWIVW 203
            .|:  |.:.:..|..:|...:||...:|.|..||.|      ||..::..    .|||:..::|.
Human   132 CSS--EFLASLPQPKSHLSVATGFGCATIFWLLKYR------PEFLKSYD----AAGTIHDYVVA 184

  Fly   204 NLTNGALHITDVTNASRTLLMNLETQAWDPVLLKTFGIREEMLPTIHSCSEIFGKITSERSPL-R 267
            .|......:....||:.....|.::|:|:...|::.|....:||.|.....:.|:.:.....: :
Human   185 MLCGLPRPLMSDQNAASWGYFNTQSQSWNVETLRSSGFPVHLLPDIAEPGSVAGRTSHMWFEIPK 249

  Fly   268 GMTLSGIMGNQQASLLGQMCVKPGQTKN---------TYRSGCFLLCNTGDK-------PVFSR- 315
            |..:...:|:.|||:...|..:.....|         :..|| |....|.|.       |.|:|
Human   250 GTQVGVALGDLQASVYSCMAQRTDAVLNISTSVQLAASMPSG-FQPAQTPDPTAPVAYFPYFNRT 313

  Fly   316 ------------------HGLLTTVA-YKLGPQAPTIYA--IEGAV-----------SVAGHALS 348
                              |.|:..:| ..|..:..|:|:  |:.||           :|.|.
Human   314 YLGVAASLNGGNVLATFVHMLVQWMADLGLEVEESTVYSRMIQAAVQQRDTHLTITPTVLGE--- 375

  Fly   349 WLQNKVRILPDSRDAEKYAEMVPTSGDVYFVPAFTGLYAPYWRQNARGIIIGLTQFTRKNHIVRA 413
                  |.|||.                         .|...|.::..:.:|        |:.||
Human   376 ------RHLPDQ-------------------------LASVTRISSSDLSLG--------HVTRA 401

  Fly   414 ALESICFQTRDILECMH--------QECGYEINKLHADGKLTTNNLLMQLQADTIGMPVFRSQLM 470
                :|   |.|::.:|        ||.|.| ..:.:...|:.|::|.|.......:|:...|.:
Human   402 ----LC---RGIVQNLHSMLPIQQLQEWGVE-RVMGSGSALSRNDVLKQEVQRAFPLPMSFGQDV 458

  Fly   471 DSTAFGAAM 479
            |: |.|||:
Human   459 DA-AVGAAL 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk2	NP_001286904.1	glycerol_kin	31..533	CDD:273549	111/529 (21%)
Gk2	NP_001286904.1	FGGY_GK1-3_metazoa	31..533	CDD:212664	111/529 (21%)
SHPK	NP_037408.2	FGGY_SHK_like	5..468	CDD:212661	111/529 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810