DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gk2 and Gk2

DIOPT Version :9

Sequence 1:	NP_001286904.1	Gene:	Gk2 / 38221	FlyBaseID:	FBgn0035266	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_034424.1	Gene:	Gk2 / 14626	MGIID:	1329027	Length:	554	Species:	Mus musculus

Alignment Length:	554	Identity:	255/554 - (46%)
Similarity:	365/554 - (65%)	Gaps:	26/554 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LVGVIDEGTKTIGFSIYTTPDFKEIAAHRVELSVITPQDGWYEQDPLEMMASINKCAEEAIKQLP 96
            |||.:.:||.:..|.::.:...:.:.:|:|||:...|::||.||||.|::.|:.:|..:|.::|.
Mouse    12 LVGAVVQGTNSTRFLVFNSKTAELVCSHQVELTQEYPKEGWVEQDPKEILKSVYECIAKACEKLA 76

  Fly    97 EQGFSASDIVTVGITNQRETTIVWDAVTGKPLYNALLWKDIRTSTTVEQIVAKVQDPNHF-RSST 160
            |.....|:|..:|::||||||:|||..||.|||||::|.|:||.:|||.:..|:...::| :|.|
Mouse    77 EVNIDISNIKAIGVSNQRETTVVWDKFTGDPLYNAVVWLDLRTQSTVETLTKKIPGNSNFVKSKT 141

  Fly   161 GLPISTYFSALKIRWLRDNVPEVRQAIRERRCKAGTVDSWIVWNLT---NGALHITDVTNASRTL 222
            |||:||||||:|:||:.||:..:::|:.|.|...||:|||::|.:|   ||.:|.||||||.||:
Mouse   142 GLPLSTYFSAVKLRWMLDNLRPIQKAVEEGRAMFGTIDSWLIWCMTGGVNGGIHCTDVTNACRTM 206

  Fly   223 LMNLETQAWDPVLLKTFGIREEMLPTIHSCSEIFGKITSERSPLRGMTLSGIMGNQQASLLGQMC 287
            |.|:.:..||..|...|.|...:||.:.|.|||:|.:||  ..|.|:.:||.:|:|.|:|:||||
Mouse   207 LFNIHSLEWDKDLCDFFEIPMSILPNVCSSSEIYGLMTS--GALEGVPISGCLGDQSAALVGQMC 269

  Fly   288 VKPGQTKNTYRSGCFLLCNTGDKPVFSRHGLLTTVAYKLGPQAPTIYAIEGAVSVAGHALSWLQN 352
            ...||.||||.:|||||||||.|.|||.||||||:|||||...|..||:||:|::||..:.||::
Mouse   270 FHEGQAKNTYGTGCFLLCNTGQKCVFSEHGLLTTLAYKLGKNKPVFYALEGSVAIAGAVIRWLRD 334

  Fly   353 KVRILPDSRDAEKYAEMVPTSGDVYFVPAFTGLYAPYWRQNARGIIIGLTQFTRKNHIVRAALES 417
            ...|:..|.:.|..|..|.||...||||||:|||||||..:|||||.||||||.|.||..||||:
Mouse   335 NFEIITTSGEVENLAREVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEA 399

  Fly   418 ICFQTRDILECMHQECGYEINKLHADGKLTTNNLLMQLQADTIGMPVFRSQLMDSTAFGAAMCAA 482
            :|||||:||:.|:::||..::.|..||.:|.|.:|||||||.:.:||.:|.:.::||.||||.|.
Mouse   400 VCFQTREILDAMNRDCGIPLSHLQVDGGMTNNRILMQLQADILHIPVVKSVMPETTALGAAMAAG 464

  Fly   483 QADGVNLCQFEPE-------KRYYENVHYDTFLATTTDVERKERYGKWKRAVERSLGWVIKQKKT 540
            .|:|||:...|||       :||...:.     ||.:::    |:..|||||.:|:|||    ..
Mouse   465 AAEGVNVWSLEPEDLSTILMERYEPQIQ-----ATESEI----RFSTWKRAVMKSMGWV----TA 516

  Fly   541 REYTEENYRMLSSLPASIFLISSFAMLVHSLAAS 574
            ::....:..:.|.||...|::||..:|:.:...|
Mouse   517 KDPENGDNPVFSCLPLGFFIVSSMTLLIGARCVS 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk2	NP_001286904.1	glycerol_kin	31..533	CDD:273549	244/511 (48%)
Gk2	NP_001286904.1	FGGY_GK1-3_metazoa	31..533	CDD:212664	244/511 (48%)
Gk2	NP_034424.1	glycerol_kin	11..513	CDD:273549	244/511 (48%)
Gk2	NP_034424.1	FGGY_GK1-3_metazoa	11..513	CDD:212664	244/511 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833650
Domainoid	1	1.000	45	1.000	Domainoid score	I12120
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60628
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001035
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100613
Panther	1	1.100	-	-	O	PTHR10196
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1107
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.710