DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gk2 and Gykl1

DIOPT Version :9

Sequence 1:	NP_001286904.1	Gene:	Gk2 / 38221	FlyBaseID:	FBgn0035266	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_034423.2	Gene:	Gykl1 / 14625	MGIID:	891990	Length:	549	Species:	Mus musculus

Alignment Length:	541	Identity:	253/541 - (46%)
Similarity:	365/541 - (67%)	Gaps:	12/541 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LVGVIDEGTKTIGFSIYTTPDFKEIAAHRVELSVITPQDGWYEQDPLEMMASINKCAEEAIKQLP 96
            |||.:|:||.:..|.::.....:.:..|:||::...|::||.||||..::.|:.:|.|:|.::|.
Mouse    12 LVGAVDQGTSSTRFLVFNPQTAELLCHHQVEIAQEFPKEGWVEQDPKAILQSVYECIEKACEKLG 76

  Fly    97 EQGFSASDIVTVGITNQRETTIVWDAVTGKPLYNALLWKDIRTSTTVEQIVAKVQDPNHF-RSST 160
            :|....|:|..:|:|||||||||||..||:|||||::|.|:||.:|||.:...:...|:| ::.|
Mouse    77 QQSIDISNIKAIGVTNQRETTIVWDKFTGEPLYNAVVWLDLRTQSTVENLSKSISVSNNFVKNKT 141

  Fly   161 GLPISTYFSALKIRWLRDNVPEVRQAIRERRCKAGTVDSWIVWNLT---NGALHITDVTNASRTL 222
            ||||||||||:|:.||.:||.:|::||.:.|...||||||::|.:|   ||.:|.|||:|||||:
Mouse   142 GLPISTYFSAVKLHWLIENVRKVQKAIEDGRAIFGTVDSWLIWCMTGGINGGVHCTDVSNASRTM 206

  Fly   223 LMNLETQAWDPVLLKTFGIREEMLPTIHSCSEIFGKITSERSPLRGMTLSGIMGNQQASLLGQMC 287
            |.|:.:..||..|...|||...:||.|.|.|||:|.:.|  ..|.|:.:||.:|:|.|:|:||:|
Mouse   207 LFNIHSLQWDEELCDFFGIPMTILPRIRSSSEIYGLVKS--GVLEGVPISGCLGDQSAALVGQLC 269

  Fly   288 VKPGQTKNTYRSGCFLLCNTGDKPVFSRHGLLTTVAYKLGPQAPTIYAIEGAVSVAGHALSWLQN 352
            ::.||.|:||.:|||||||||.|.|.|.|||||||||:||.|.|..||:||:|::||..:||::|
Mouse   270 LQDGQAKSTYGTGCFLLCNTGQKCVNSEHGLLTTVAYQLGRQEPVYYALEGSVAIAGAVVSWIKN 334

  Fly   353 KVRILPDSRDAEKYAEMVPTSGDVYFVPAFTGLYAPYWRQNARGIIIGLTQFTRKNHIVRAALES 417
            .::|:..|.:.||.||:..||...||||||:|||||||..:|||||.||||||.|.||..||||:
Mouse   335 NLQIIQSSSEIEKLAEVAGTSYGCYFVPAFSGLYAPYWDPSARGIICGLTQFTNKFHIAFAALEA 399

  Fly   418 ICFQTRDILECMHQECGYEINKLHADGKLTTNNLLMQLQADTIGMPVFRSQLMDSTAFGAAMCAA 482
            :|||||:||:.|:.:||..:..|..||.:|.|.:|||||||.:.:||.:..:.::||.|.||.|.
Mouse   400 VCFQTREILDAMNSDCGIPLTHLQVDGGMTANRVLMQLQADILCIPVMKPFMPETTALGVAMAAG 464

  Fly   483 QADGVNLCQFEPEKRYYENVHYDTFLATTTDVERKERYGKWKRAVERSLGWVIKQKKTREYTEEN 547
            .|:||::...:|:.  ..:|..:.|.......|.:.||..||:||.:|:|||:    |:.....:
Mouse   465 AAEGVSVWSLDPKD--LSSVQMEKFEPQINVEESEGRYATWKKAVLKSMGWVL----TQSPDGRD 523

  Fly   548 YRMLSSLPASIFLISSFAMLV 568
            ..:.|||....:::||..:|:
Mouse   524 PSIFSSLTLGFYVVSSMVILI 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk2	NP_001286904.1	glycerol_kin	31..533	CDD:273549	243/504 (48%)
Gk2	NP_001286904.1	FGGY_GK1-3_metazoa	31..533	CDD:212664	243/504 (48%)
Gykl1	NP_034423.2	glycerol_kin	11..513	CDD:273549	243/504 (48%)
Gykl1	NP_034423.2	FGGY_GK1-3_metazoa	11..513	CDD:212664	243/504 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833648
Domainoid	1	1.000	45	1.000	Domainoid score	I12120
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21848
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60628
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	1	1.000	-	-		FOG0001035
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100613
Panther	1	1.100	-	-	O	PTHR10196
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1107
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.720