DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gk2 and AgaP_AGAP001563

DIOPT Version :9

Sequence 1:	NP_001286904.1	Gene:	Gk2 / 38221	FlyBaseID:	FBgn0035266	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	XP_321549.1	Gene:	AgaP_AGAP001563 / 1281605	VectorBaseID:	AGAP001563	Length:	555	Species:	Anopheles gambiae

Alignment Length:	551	Identity:	312/551 - (56%)
Similarity:	420/551 - (76%)	Gaps:	9/551 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 IQHTGLVGVIDEGTKTIGFSIYTTPDFKEIAAHRVELSVITPQDGWYEQDPLEMMASINKCAEEA 91
            ::.:.|:||||.||.::.|.|:..|:|:|||:|::.::.|.|:|||.|.:|:|::.::..||.||
Mosquito     4 LERSKLIGVIDAGTNSVRFVIFKLPEFEEIASHQIRITQIVPRDGWTEHNPVEVLEAVRLCAVEA 68

  Fly    92 IKQLPEQGFSASDIVTVGITNQRETTIVWDAVTGKPLYNALLWKDIRTSTTVEQIVAKV--QDPN 154
            ..|:.:.||...||..:|||||||||:|||..||:|||||::|.||||..||::::|::  |:.|
Mosquito    69 CHQVEKLGFLVKDIAAIGITNQRETTVVWDKNTGEPLYNAIVWNDIRTDKTVDRVLARLPEQNHN 133

  Fly   155 HFRSSTGLPISTYFSALKIRWLRDNVPEVRQAIRERRCKAGTVDSWIVWNLT---NGALHITDVT 216
            |||:.:|||||.||||||:.||:|||..||:|.|||||.|||:|:|:|||||   .|...:||||
Mosquito   134 HFRALSGLPISPYFSALKLNWLKDNVVAVRKACRERRCYAGTIDTWLVWNLTGGPQGGAFVTDVT 198

  Fly   217 NASRTLLMNLETQAWDPVLLKTFGIREEMLPTIHSCSEIFGKITSERSPLRGMTLSGIMGNQQAS 281
            |||||||||:||..|||:|.|||.:..:|||.|.|.|||:||: .:.|.|.|:.:|.|:||||||
Mosquito   199 NASRTLLMNIETLHWDPLLTKTFSVHPDMLPEIRSSSEIYGKV-KDSSVLDGIPISAILGNQQAS 262

  Fly   282 LLGQMCVKPGQTKNTYRSGCFLLCNTGDKPVFSRHGLLTTVAYKLGPQAPTIYAIEGAVSVAGHA 346
            |:||.|:|.||.|||||.|||||.|||.:.|.|.|||:|||||::|..||.|||:||:|:|||.|
Mosquito   263 LVGQRCLKEGQAKNTYRKGCFLLYNTGTRCVQSTHGLVTTVAYQMGRNAPPIYALEGSVAVAGVA 327

  Fly   347 LSWLQNKVRILPDSRDAEKYAEMVPTSGDVYFVPAFTGLYAPYWRQNARGIIIGLTQFTRKNHIV 411
            ::||::.::|:.|.:|:|:.|..|.::||||||||||||||||||::||||..|||.||.|:|.|
Mosquito   328 MNWLRDNLKIIKDIKDSEEIAGSVSSTGDVYFVPAFTGLYAPYWRKDARGIFCGLTSFTTKHHFV 392

  Fly   412 RAALESICFQTRDILECMHQECGYEINKLHADGKLTTNNLLMQLQADTIGMPVFRSQLMDSTAFG 476
            |||||::|||||||:|.|.::||..:||||.||.:.:|:||||||||..|:||.|:::.:..|.|
Mosquito   393 RAALEAVCFQTRDIIEAMKKDCGINLNKLHTDGIMASNSLLMQLQADLSGIPVLRTEVHEPAALG 457

  Fly   477 AAMCAAQADGVNLCQFEPEKRYYENV--HYDTFLATTTDVERKERYGKWKRAVERSLGWVIKQKK 539
            .||.||||:||:|.:.|.|.|.|..|  |::|||.|||:.||..||.|||.||:|||||.: .||
Mosquito   458 TAMAAAQANGVDLYKLEAEIRGYAGVQSHHETFLPTTTEEERNARYTKWKMAVQRSLGWAV-SKK 521

  Fly   540 TREYTEENYRMLSSLPASIFLISSFAMLVHS 570
            :...|:|.|.:|:|:||.:||.::|.|||||
Mosquito   522 SEAMTDERYSLLASIPAGLFLATTFLMLVHS 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk2	NP_001286904.1	glycerol_kin	31..533	CDD:273549	293/508 (58%)
Gk2	NP_001286904.1	FGGY_GK1-3_metazoa	31..533	CDD:212664	293/508 (58%)
AgaP_AGAP001563	XP_321549.1	glycerol_kin	8..516	CDD:273549	293/508 (58%)
AgaP_AGAP001563	XP_321549.1	NBD_sugar-kinase_HSP70_actin	8..516	CDD:302596	293/508 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	304	1.000	Domainoid score	I3639
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21848
Inparanoid	1	1.050	649	1.000	Inparanoid score	I2111
OMA	1	1.010	-	-		QHG60628
OrthoDB	1	1.010	-	-		D18729at7147
OrthoFinder	1	1.000	-	-		FOG0001035
OrthoInspector	1	1.000	-	-		oto105670
Panther	1	1.100	-	-	LDO	PTHR10196
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1107
TreeFam	1	0.960	-	-
	13	12.940