DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gk2 and Xylb

DIOPT Version :9

Sequence 1:	NP_001286904.1	Gene:	Gk2 / 38221	FlyBaseID:	FBgn0035266	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001028381.1	Gene:	Xylb / 102448	MGIID:	2142985	Length:	551	Species:	Mus musculus

Alignment Length:	505	Identity:	106/505 - (20%)
Similarity:	179/505 - (35%)	Gaps:	138/505 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 SIYTTPDFKE------IAAHRVELSVITPQDGWYEQDPLEMMASINKCAEEAIKQLPEQGFSASD 104
            |::...|..|      :..|:..|:|.:|...|.:  .|:::          :.::...||..|.
Mouse    51 SVHFDRDLPEFGTQGGVHVHKDRLTVTSPVLMWVQ--ALDLI----------LGKMKSSGFDFSQ 103

  Fly   105 IVTVGITNQRETTIVWDAVTGK-----------PLYNAL----------LWKDIRTSTTVEQIVA 148
            ::.:....|:..::.|.  ||.           ||:..|          :|.|..|:....|:.|
Mouse   104 VLALSGAGQQHGSVYWK--TGASLALSSLSPALPLHQQLQSCFSISDCPIWMDSSTTAQCHQLEA 166

  Fly   149 KVQDPNHFRSSTGLPISTYFSALKIRWLRDNVPEVRQAIRERRCKAGTVDSWIVWNLTNGALHIT 213
            .|.........||......|:..:|..|....||. .:..||   ...|.|:.. :|..|.....
Mouse   167 AVGGAQALSCLTGSRAYERFTGNQIAKLFQKNPEA-YSHSER---ISLVSSFAA-SLFLGGYSPI 226

  Fly   214 DVTNASRTLLMNLETQAWDPVLLKTFG--IREEMLPTIHSCSEIFGKITS---ER---SPLRGMT 270
            |.::.|...|:.::.:.|....|....  :.|::...:.||| :.|.|:|   :|   .|  |..
Mouse   227 DYSDGSGMNLLQIQEKVWSQACLDVCAPHLEEKLGSPVPSCS-VVGTISSYYVQRYGFPP--GCK 288

  Fly   271 LSGIMGNQQASLLGQMCVKPGQ------TKNTYRSGCFL-------------LCNTGDKPVFSRH 316
            :....|:..|||.| |.::.|.      |.:|    .||             .||    ||..:|
Mouse   289 VVAFSGDNPASLAG-MRLEEGDIAVSLGTSDT----LFLWLQKPMPALEGHIFCN----PVDPQH 344

  Fly   317 GLLTTVAYKLGPQAPTIYAIEGAVSVAGHALSWLQNKVRILPDSRDAEKYAEMVPT-----SGDV 376
             .:..:.:|.|                    |.::.|:|....|....|:::.:.:     :|::
Mouse   345 -YMALLCFKNG--------------------SLMREKIRDESASCSWNKFSKALKSTAMGNNGNL 388

  Fly   377 YFVPAFTGLYAPYWRQNARGIIIGLTQFTRKNHIV---------RAALESICFQTRDILECMHQE 432
                   |.|.........  |||..:|..:|..|         ||.:|......|     :|.|
Mouse   389 -------GFYFDVMEITPE--IIGRHRFNAENMEVSAFPGDVEIRALIEGQFMAKR-----IHAE 439

  Fly   433 -CGYEI---NKLHADGKLTTNNLLMQLQADTIGMPVFRSQLMDSTAFGAA 478
             .||.:   .|:.|.|..:.|..::|:.||..|.||:......|...|:|
Mouse   440 GLGYRVMPKTKILATGGASHNKDILQVLADVFGAPVYVIDTTSSACVGSA 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk2	NP_001286904.1	glycerol_kin	31..533	CDD:273549	106/505 (21%)
Gk2	NP_001286904.1	FGGY_GK1-3_metazoa	31..533	CDD:212664	106/505 (21%)
Xylb	NP_001028381.1	FGGY_D-XK_euk	24..494	CDD:212660	106/505 (21%)
Xylb	NP_001028381.1	PLN02669	26..549	CDD:178274	106/505 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910