DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gk2 and zgc:172295

DIOPT Version :9

Sequence 1:	NP_001286904.1	Gene:	Gk2 / 38221	FlyBaseID:	FBgn0035266	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	XP_009289955.1	Gene:	zgc:172295 / 100136866	ZFINID:	ZDB-GENE-080204-72	Length:	570	Species:	Danio rerio

Alignment Length:	564	Identity:	259/564 - (45%)
Similarity:	372/564 - (65%)	Gaps:	32/564 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LVGVIDEGTKTIGFSIYTTPDFKEIAAHRVELSVITPQDGWYEQDPLEMMASINKCAEEAIKQLP 96
            ||..||:||.:..|.::.....:.::.|:||:....|::||.|:||.|::.|:.:|.:...::|.
Zfish    17 LVAAIDQGTSSTRFLVFNAKTAELLSHHQVEIKQSFPKEGWVEEDPKEILQSVYECMDRTCEKLT 81

  Fly    97 EQGFSASDIVTVGITNQRETTIVWDAVTGKPLYNALLWKDIRTSTTVEQIVAKV--QDPNHFRSS 159
            :.....|:|..||:|||||||:|||..||:|||||::|.|:||.:|||:::.|.  ::.||.:..
Zfish    82 QLNIDVSNIKAVGVTNQRETTLVWDKQTGEPLYNAIVWLDLRTQSTVERLINKTPGKNKNHLKDK 146

  Fly   160 TGLPISTYFSALKIRWLRDNVPEVRQAIRERRCKAGTVDSWIVWNLT---NGALHITDVTNASRT 221
            |||||||||||:|:|||.|||.:|.:|:...|...||||||::|.||   ||.:|.|||||||||
Zfish   147 TGLPISTYFSAVKLRWLMDNVEKVHEAVLSHRAMFGTVDSWLIWCLTGGKNGGVHCTDVTNASRT 211

  Fly   222 LLMNLETQAWDPVLLKTFGIREEMLPTIHSCSEIFG--KITS--ERSPLRGMTLSGIMGNQQASL 282
            :|.|:.|..|||.|...|.|...:||.:.|.|||:|  ||:|  :..||.|:.:||.:|:|.|:|
Zfish   212 MLFNIHTMDWDPELCIYFDIPMGILPKVRSSSEIYGLMKISSKLKSGPLTGVPISGCLGDQSAAL 276

  Fly   283 LGQMCVKPGQTKNTYRSGCFLLCNTGDKPVFSRHGLLTTVAYKLGPQAPTIYAIEGAVSVAGHAL 347
            :||||.|.||.||||.:|||||.|.|.|||.|.||||||||||||...|..||:||:|::||..:
Zfish   277 VGQMCFKDGQAKNTYGTGCFLLKNVGTKPVMSDHGLLTTVAYKLGRDKPACYALEGSVAIAGAVV 341

  Fly   348 SWLQNKVRILPDSRDAEKYAEMVPTSGDVYFVPAFTGLYAPYWRQNARGIIIGLTQFTRKNHIVR 412
            .||::.:.|:..|.:.||.|..|.||...||||||:|||||||..:|||||.||||||.::|:..
Zfish   342 RWLKDNLGIIQTSTELEKLAADVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNRSHLAF 406

  Fly   413 AALESICFQTRDILECMHQECGYEINKLHADGKLTTNNLLMQLQADTIGMPVFRSQLMDSTAFGA 477
            ||||::|||||:||:.|:|:.|..:::|..||.:|:|.||||||||.:.:||.:..:.::||.||
Zfish   407 AALEAVCFQTREILDAMNQDSGINLSQLQVDGGMTSNRLLMQLQADILCIPVVKPSMPETTALGA 471

  Fly   478 AMCAAQADGVNLCQFEPE-------KRYYENVHYDTFLATTTDVERKERYGKWKRAVERSLGWVI 535
            ||.|..|:||::....||       :::...::        .:.|.:.||.:||:||:|::.|
Zfish   472 AMAAGAAEGVSVWSLNPEDLTEVTSEKFEPQIN--------PEAESELRYARWKKAVQRAMNW-- 526

  Fly   536 KQKKTREYT---EENYRMLSSLPASIFLISSFAMLVHSLAASGQ 576
               :|.|..   .|:..:.||:|...:::.|..||:.:...:||
Zfish   527 ---ETIEPVNSGNEDTSIFSSVPLGFYILGSMFMLIGAKYIAGQ 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk2	NP_001286904.1	glycerol_kin	31..533	CDD:273549	247/516 (48%)
Gk2	NP_001286904.1	FGGY_GK1-3_metazoa	31..533	CDD:212664	247/516 (48%)
zgc:172295	XP_009289955.1	glycerol_kin	16..526	CDD:273549	247/516 (48%)
zgc:172295	XP_009289955.1	FGGY_GK1-3_metazoa	16..526	CDD:212664	247/516 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576365
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21848
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60628
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	1	1.000	-	-		FOG0001035
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100613
Panther	1	1.100	-	-	O	PTHR10196
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1107
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.720