DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gk2 and gk

DIOPT Version :9

Sequence 1:	NP_001286904.1	Gene:	Gk2 / 38221	FlyBaseID:	FBgn0035266	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	XP_012811696.1	Gene:	gk / 100038285	XenbaseID:	XB-GENE-961541	Length:	562	Species:	Xenopus tropicalis

Alignment Length:	555	Identity:	264/555 - (47%)
Similarity:	374/555 - (67%)	Gaps:	18/555 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LVGVIDEGTKTIGFSIYTTPDFKEIAAHRVELSVITPQDGWYEQDPLEMMASINKCAEEAIKQLP 96
            |||.||:||.:..|.::.....:.::.|:||:....|::||.||||.|::.|:.:|.|:..::|.
Frog    12 LVGAIDQGTSSTRFLVFNAKTAELLSHHQVEIKQKFPKEGWVEQDPKEILQSVYECVEKTCEKLT 76

  Fly    97 EQGFSASDIVTVGITNQRETTIVWDAVTGKPLYNALLWKDIRTSTTVEQIVAKV--QDPNHFRSS 159
            :.....::|..:|::||||||:|||..||:|||||::|.|:||.:|||:::.::  ::.|.|:|.
Frog    77 QLNIDITNIKAIGVSNQRETTVVWDKTTGEPLYNAVVWLDLRTQSTVERLLKRIPGKNKNFFKSR 141

  Fly   160 TGLPISTYFSALKIRWLRDNVPEVRQAIRERRCKAGTVDSWIVWNLT---NGALHITDVTNASRT 221
            ||||:||||||:|||||.|||.|:|.|:.|.|...|||||||:|:||   ||.:|.|||||||||
Frog   142 TGLPLSTYFSAVKIRWLLDNVEEIRHAVSEGRAMFGTVDSWIIWSLTGAKNGGVHCTDVTNASRT 206

  Fly   222 LLMNLETQAWDPVLLKTFGIREEMLPTIHSCSEIFG--KI--TSERSPLRGMTLSGIMGNQQASL 282
            :|.|:.|..||..|.:.|.|..|:||.:.|.|||:|  ||  :.:...|.|:.:||.:|:|.|:|
Frog   207 MLFNIHTLEWDTELCQFFDIPMELLPKVRSSSEIYGLMKICPSLKSGALTGVPISGCLGDQSAAL 271

  Fly   283 LGQMCVKPGQTKNTYRSGCFLLCNTGDKPVFSRHGLLTTVAYKLGPQAPTIYAIEGAVSVAGHAL 347
            :||||.:.||.||||.:|||||||||.|||.|.||||||||||||...|..||:||:|::||..:
Frog   272 VGQMCFQDGQAKNTYGTGCFLLCNTGSKPVLSEHGLLTTVAYKLGRDKPACYALEGSVAIAGAVV 336

  Fly   348 SWLQNKVRILPDSRDAEKYAEMVPTSGDVYFVPAFTGLYAPYWRQNARGIIIGLTQFTRKNHIVR 412
            .||::.:.|:..:.:.||.|..|.||...||||||:|||||||..:|||||.||||||.:|||..
Frog   337 RWLRDNLGIVKTTEEVEKLAAEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNRNHIAF 401

  Fly   413 AALESICFQTRDILECMHQECGYEINKLHADGKLTTNNLLMQLQADTIGMPVFRSQLMDSTAFGA 477
            ||||::|||||:||:.|:::||..:|:|..||.:|:|.:|||||||.:.:||.:..:.::||.||
Frog   402 AALEAVCFQTREILDAMNKDCGIPLNQLQVDGGMTSNKILMQLQADILCIPVVKPSMPETTALGA 466

  Fly   478 AMCAAQADGVNLCQFEPEKRYYENVHYDTFLATTTDVERKERYGKWKRAVERSLGWVIKQKKTRE 542
            ||.|..|:||.:....|..  ...|..:.|.......|.:.||.:||:||.:|:||     ::.|
Frog   467 AMAAGAAEGVGVWSLNPGD--LTAVTCERFEPQINPEESEFRYARWKKAVMKSMGW-----ESAE 524

  Fly   543 YTEEN--YRMLSSLPASIFLISSFAMLVHSLAASG 575
            .|..|  ..:..|||...:::||..:|:.:...||
Frog   525 PTNGNGDCSIFCSLPLGFYIVSSMVLLIGAKYISG 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk2	NP_001286904.1	glycerol_kin	31..533	CDD:273549	251/509 (49%)
Gk2	NP_001286904.1	FGGY_GK1-3_metazoa	31..533	CDD:212664	251/509 (49%)
gk	XP_012811696.1	FGGY_GK1-3_metazoa	11..520	CDD:212664	251/509 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21848
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60628
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	1	1.000	-	-		FOG0001035
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10196
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1107
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.030