Protein Alignment Oseg4 and Wdr35

DIOPT Version :10

• Sequence 1: NP_647653.1
• Gene: Oseg4 / 38219
• FlyBaseID: FBgn0035264
• Length: 1205
• Species: Drosophila melanogaster
• Sequence 2: NP_766058.3
• Gene: Wdr35 / 74682
• MGIID: 1921932
• Length: 1181
• Species: Mus musculus
• Alignment Length: 1232
• Identity: 584/1232 - (47%)
• Similarity: 789/1232 - (64%)
• Gaps: 86/1232 - (6%)

  Fly     1 MFVYLSKKIAIPNNVKLNCIAWNKEEGYIAVAGTDGLLKVLKLDQATPNGQSKGGLAAVSNLSMN 65
            ||.|||||||:||||||.||:|||::|:||..|.|||||||:|:..|.:.:.: ||||.||||||
Mouse     1 MFFYLSKKIAVPNNVKLKCISWNKDQGFIACGGEDGLLKVLRLETQTDDSKLR-GLAAPSNLSMN 64

  Fly    66 QTLDGHKESVRVVTWNDAQQKLTSSDTDGVIMVWMLYKGSWYEEMTNDRKKSTVASMSWTSDGSR 130
            |.|:||..:|:|||||:..||||:||.:|:|:|||||||||||||.|:|.||.|.||||.:||.:
Mouse    65 QNLEGHSGAVQVVTWNEQYQKLTTSDQNGLIIVWMLYKGSWYEEMINNRNKSVVRSMSWNADGQK 129

  Fly   131 ICIVYEDGAIIVGSVDGNRIFGKELKGTHLTGVQWSPDNRLILFALANGECHLYDNQGNFAMKLH 195
            |||||||||:||||||||||:||:|||..|..|.||.|::::||.:||||.|:|||||||.||:.
Mouse   130 ICIVYEDGAVIVGSVDGNRIWGKDLKGIQLCHVTWSADSKILLFGMANGEIHIYDNQGNFIMKMK 194

  Fly   196 IQC-VNISGGSSSRGHRIASICWFSGR--VVQSRKRPVLAICYENGRVQIMRNENDDAPAIFDTG 257
            :.| ||::|..|     ||.|.|:.|.  .|:. ..|.||||::|||.||||:|||..|.:.|||
Mouse   195 LNCLVNVTGAIS-----IAGIHWYHGTEGYVEP-DCPCLAICFDNGRCQIMRHENDQNPVLIDTG 253

  Fly   258 MRNVDAKWNHDGTVLAICGTTLDAVSPTSQRDTNQVCFYSPLGKIYRTLKVPGTDITSLSWEGKS 322
            |..|..:|||.|:|||:.|:....   |..:|.|.|.||:|.|:...||||||..:.||||||..
Mouse   254 MYVVGIQWNHIGSVLAVAGSQKVV---TQDKDINIVQFYTPFGEHLGTLKVPGKQMCSLSWEGGG 315

  Fly   323 LRIAMAVDSFIYFANIRPDYIWCYFEKTVVFLNSGSATR-ESPMSVITFWNTVSNQSFLKEVEPT 386
            |:||:|||||||||||||||.|.|...|||:    :.|| :.|...:.||:|.:::.::|.|:..
Mouse   316 LKIALAVDSFIYFANIRPDYKWGYCSNTVVY----AYTRPDRPEYCVVFWDTKNSEKYVKYVKSL 376

  Fly   387 LCLASSSEHCVLGVECVSSNIKEIALSTLENRSNPADDR-------VYQLLLCNSIGTTVDSKYT 444
            :.:.:..:.|:              |:|..:.::|.::.       .:.|:|||||||.:|.||.
Mouse   377 ISITTCGDFCI--------------LATKADENHPQEENEMETFGATFVLVLCNSIGTPLDPKYI 427

  Fly   445 DIRPCFVGINSSYVAIASQEEILIWHYHTPKSASTL---HNVKARKEKR---FHIDDTPTGVEMA 503
            |:.|.||.:..::|..||:|....|.|...|..:.|   ...::|||.|   :|:||.|:|
Mouse   428 DLVPLFVAMTKTHVIAASKEAFYTWQYRVAKKLTALEINQITRSRKEGRERIYHVDDVPSG---- 488

  Fly   504 KDLMLSSSSG--DGHSTQRGISDPICALALSEKLLLVARESGAINEYSIANVALRNRHLMNAKVY 566
                  |..|  |.....:|..|||||:..|:|.|:|.||||.|..||..||||..::.::.:..
Mouse   489 ------SVDGVFDYSKAIQGTRDPICAITASDKTLIVGRESGVIQRYSFPNVALIQKYSLDCRAC 547

  Fly   567 KMAINCNSTRAAIIDHMGVMTLLDLD----DNRETQL--NFSRVERKDVWAVSWATDNPLLLALM 625
            ::::||||:|.||||..||:|..|||    |:...|:  ...::||||||.:.||.|||.|.|:|
Mouse   548 QLSLNCNSSRLAIIDIAGVLTFFDLDTRVTDSTGQQVVGELLKLERKDVWDMKWAKDNPDLFAMM 612

  Fly   626 EKTRMYIFRGNDPEEPVSCSGYICTFEDLEITSVLLDDIISVGELQNFSHIIQLRVKSLRDTDDL 690
            ||||||:||..|||||:..|||||.||||||.|||||:|:...|..:..:|:...::||||:..|
Mouse   613 EKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPSKDYIMNFEIRSLRDSRAL 677

  Fly   691 LEHVGLEDAKQFIEDNPHPRLWRLLAESALKKLELETAENAFVRCAHYPGIKLVKRLRTIHSKEL 755
            :|.||:|||.|||||||||||||||||:||:||:|.||:.|||||..|.|||.||.|..:.|:.:
Mouse   678 IEKVGIEDASQFIEDNPHPRLWRLLAEAALQKLDLYTAQQAFVRCKDYQGIKFVKLLGNLQSESM 742

  Fly   756 QRAEISAFYGEFEEAEKLYLDADRRDLAIELRMTLCDWFRVVQLYRMGGSGVSDQQMEIAWREIG 820
            ::||:.|::|.||:||::|.|.|||||||.|||.|.|||||:||.:.|.....|..:|.|...||
Mouse   743 KQAEVIAYFGRFEDAERMYQDMDRRDLAIGLRMKLGDWFRVLQLLKTGSGDADDSLLEQANNAIG 807

  Fly   821 HHFANLRSWESAREYYEKSHYLEGYMEALYHLEQFDDLEKCVERLPEKSPLLPKLAEMLASVGMC 885
            .:||:.:.|::|.:||.|....|...|..|.||.::.||.....|||...|||::|:|...||||
Mouse   808 EYFADRQKWQNAVQYYVKGRNQERLAECYYMLEDYEGLETLANSLPENHKLLPEIAQMFVRVGMC 872

  Fly   886 SEAVQAHLRFGDQKAAVATCVNLRQWGEAVELAQRFQLPQVQTLIAKHAAQLLQEGRLKEAIEMQ 950
            .:||.|.|:....||||.|||:|.||.:|||||:...:.::.:|:|::|:.||::.:..:|||:.
Mouse   873 EQAVSAFLKCNQPKAAVDTCVHLNQWNKAVELAKSHSMKEIGSLLARYASHLLEKNKTLDAIELY 937

  Fly   951 RNAGRHLDAARLLSQMAEREQEKRAPLLRIKKLYVLAALLAEEHLKAVATTEIDYASGRNT---- 1011
            |.|....|||:|:.::|:.|.:||...||:||||||:|||.|::.:.:...:.....|:|:
Mouse   938 RKASYFFDAAKLMYKIADEEAKKRTKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKNSEATS 1002

  Fly  1012 ----LLDSIALEDAAAI-ERLWHCAEAYHFMLLAQRQLRFGIVHSAVVTAVRLRDYEDVLPPEHI 1071
                ||:...|...:.. :..|..||||||.:||||||..|.|.:|:.||:.||||||::|...|
Mouse  1003 ALAGLLEEEVLSTTSRFTDNAWRGAEAYHFFILAQRQLYEGYVDTALKTALHLRDYEDIIPSVEI 1067

  Fly  1072 YSLLALASCADRAFGTCSKAFMKLEQQAHLPEATLQRYEELAAGIFAKYDPEDTTGDRVDCYSCG 1136
            ||||||.:||.||||||||||:|||....|.....|:||:||..||.|:.|:|.....::....|
Mouse  1068 YSLLALCACASRAFGTCSKAFIKLESLETLSAEQKQQYEDLALEIFTKHTPKDNRKSELNSLLEG 1132

  Fly  1137 VPVPDSSPSCPECNARFPACISSGKPITQPTNNIWICTTCHHCAAPTEISRHRTCPLCHSLI 1198
                        ...:.|.||::|.||.:  ...|:|..|.|.....|||.:..||||||.:
Mouse  1133 ------------GEGKLPTCIATGSPIIE--YQFWVCKVCKHYVLAQEISNYNFCPLCHSSV 1180

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oseg4	NP_647653.1	WD40	<18..318	CDD:441893	171/302 (57%)
		WD40 repeat	19..70	CDD:293791	30/50 (60%)
		WD40 repeat	76..115	CDD:293791	27/38 (71%)
		WD40 repeat	119..152	CDD:293791	26/32 (81%)
		WD40 repeat	161..202	CDD:293791	23/41 (56%)
		WD40 repeat	212..280	CDD:293791	35/69 (51%)
		WD40 repeat	290..333	CDD:293791	25/42 (60%)
		COG3899	<710..1118	CDD:443106	196/416 (47%)
Wdr35	NP_766058.3	WD 1	12..51		24/38 (63%)
		WD40 repeat	18..69	CDD:293791	30/51 (59%)
		WD40	<19..>184	CDD:441893	106/165 (64%)
		WD40	67..>316	CDD:475233	146/257 (57%)
		WD 2	69..108		26/38 (68%)
		WD40 repeat	74..111	CDD:293791	27/36 (75%)
		WD 3	113..152		29/38 (76%)
		WD 4	154..193		23/38 (61%)
		WD40 repeat	205..251	CDD:293791	23/51 (45%)
		WD40 repeat	256..300	CDD:293791	18/46 (39%)
		WD40 repeat	308..345	CDD:293791	27/36 (75%)
		WD 5	502..539		21/36 (58%)
		LapB	699..940	CDD:442196	114/240 (48%)