DRSC/TRiP Functional Genomics Resources

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Protein Alignment Oseg4 and WDR35

DIOPT Version :9

Sequence 1:NP_001261278.1 Gene:Oseg4 / 38219 FlyBaseID:FBgn0035264 Length:1205 Species:Drosophila melanogaster
Sequence 2:NP_001006658.1 Gene:WDR35 / 57539 HGNCID:29250 Length:1181 Species:Homo sapiens


Alignment Length:1228 Identity:584/1228 - (47%)
Similarity:797/1228 - (64%) Gaps:82/1228 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MFVYLSKKIAIPNNVKLNCIAWNKEEGYIAVAGTDGLLKVLKLDQATPNGQSKGGLAAVSNLSMN 65
            ||.||||||:|||||||.|::||||:|:||..|.|||||||||:..|.:.:.: ||||.||||||
Human     1 MFFYLSKKISIPNNVKLQCVSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLR-GLAAPSNLSMN 64

  Fly    66 QTLDGHKESVRVVTWNDAQQKLTSSDTDGVIMVWMLYKGSWYEEMTNDRKKSTVASMSWTSDGSR 130
            |||:||..||:|||||:..||||:||.:|:|:|||||||||.|||.|:|.||.|.||||.:||.:
Human    65 QTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRSMSWNADGQK 129

  Fly   131 ICIVYEDGAIIVGSVDGNRIFGKELKGTHLTGVQWSPDNRLILFALANGECHLYDNQGNFAMKLH 195
            |||||||||:||||||||||:||:|||..|:.|.||.|::::||.:||||.|:|||||||.:|:.
Human   130 ICIVYEDGAVIVGSVDGNRIWGKDLKGIQLSHVTWSADSKVLLFGMANGEIHIYDNQGNFMIKMK 194

  Fly   196 IQC-VNISGGSSSRGHRIASICWFSGR--VVQSRKRPVLAICYENGRVQIMRNENDDAPAIFDTG 257
            :.| ||::|..|     ||.|.|:.|.  .|:. ..|.||:|::|||.||||:|||..|.:.|||
Human   195 LSCLVNVTGAIS-----IAGIHWYHGTEGYVEP-DCPCLAVCFDNGRCQIMRHENDQNPVLIDTG 253

  Fly   258 MRNVDAKWNHDGTVLAICGTTLDAVSPTSQRDTNQVCFYSPLGKIYRTLKVPGTDITSLSWEGKS 322
            |..|..:|||.|:|||:.|....|:   ..:|.|.|.||:|.|:...||||||.:|::|||||..
Human   254 MYVVGIQWNHMGSVLAVAGFQKAAM---QDKDVNIVQFYTPFGEHLGTLKVPGKEISALSWEGGG 315

  Fly   323 LRIAMAVDSFIYFANIRPDYIWCYFEKTVVFLNSGSATR-ESPMSVITFWNTVSNQSFLKEVEPT 386
            |:||:|||||||||||||:|.|.|...|||:    :.|| :.|...:.||:|.:|:.::|.|:..
Human   316 LKIALAVDSFIYFANIRPNYKWGYCSNTVVY----AYTRPDRPEYCVVFWDTKNNEKYVKYVKGL 376

  Fly   387 LCLASSSEHCVLGVECVSSNIKEIALSTLENRSNPADDR-------VYQLLLCNSIGTTVDSKYT 444
            :.:.:..:.|:              |:|..:.::|.::.       .:.|:|||||||.:|.||.
Human   377 ISITTCGDFCI--------------LATKADENHPQEENEMETFGATFVLVLCNSIGTPLDPKYI 427

  Fly   445 DIRPCFVGINSSYVAIASQEEILIWHYHTPKSASTL---HNVKARKEKR---FHIDDTPTGVEMA 503
            ||.|.||.:..::|..||:|....|.|...|..:.|   ...::|||.|   :|:||||:|   :
Human   428 DIVPLFVAMTKTHVIAASKEAFYTWQYRVAKKLTALEINQITRSRKEGRERIYHVDDTPSG---S 489

  Fly   504 KDLMLSSSSGDGHSTQRGISDPICALALSEKLLLVARESGAINEYSIANVALRNRHLMNAKVYKM 568
            .|.:|     |...|.:|..|||||:..|:|:|:|.||||.|..||:.||.|..::.:|.:.|::
Human   490 MDGVL-----DYSKTIQGTRDPICAITASDKILIVGRESGTIQRYSLPNVGLIQKYSLNCRAYQL 549

  Fly   569 AINCNSTRAAIIDHMGVMTLLDLD----DNRETQL--NFSRVERKDVWAVSWATDNPLLLALMEK 627
            ::||||:|.||||..||:|..|||    |:...|:  ...::||:|||.:.||.|||.|.|:|||
Human   550 SLNCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVVGELLKLERRDVWDMKWAKDNPDLFAMMEK 614

  Fly   628 TRMYIFRGNDPEEPVSCSGYICTFEDLEITSVLLDDIISVGELQNFSHIIQLRVKSLRDTDDLLE 692
            ||||:||..|||||:..|||||.||||||.|||||:|:...|..|..::|...::||||:..|:|
Human   615 TRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPNKDYLINFEIRSLRDSRALIE 679

  Fly   693 HVGLEDAKQFIEDNPHPRLWRLLAESALKKLELETAENAFVRCAHYPGIKLVKRLRTIHSKELQR 757
            .||::||.|||||||||||||||||:||:||:|.|||.|||||..|.|||.||||..:.|:.:::
Human   680 KVGIKDASQFIEDNPHPRLWRLLAEAALQKLDLYTAEQAFVRCKDYQGIKFVKRLGKLLSESMKQ 744

  Fly   758 AEISAFYGEFEEAEKLYLDADRRDLAIELRMTLCDWFRVVQLYRMGGSGVSDQQMEIAWREIGHH 822
            ||:..::|.|||||:.||:.|||||||.||:.|.|||||:||.:.|.....|..:|.|...||.:
Human   745 AEVVGYFGRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQANNAIGDY 809

  Fly   823 FANLRSWESAREYYEKSHYLEGYMEALYHLEQFDDLEKCVERLPEKSPLLPKLAEMLASVGMCSE 887
            ||:.:.|.:|.:||.:....|...|..|.||.::.||.....|||...|||::|:|...||||.:
Human   810 FADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAISLPENHKLLPEIAQMFVRVGMCEQ 874

  Fly   888 AVQAHLRFGDQKAAVATCVNLRQWGEAVELAQRFQLPQVQTLIAKHAAQLLQEGRLKEAIEMQRN 952
            ||.|.|:....||||.|||:|.||.:|||||:...:.::.:|:|::|:.||::.:..:|||:.|.
Human   875 AVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELYRK 939

  Fly   953 AGRHLDAARLLSQMAEREQEKRAPLLRIKKLYVLAALLAEEHLKAVATTEIDYASGRNT------ 1011
            |....|||:|:.::|:.|.:|.:..||:||||||:|||.|::.:.:...:.....|:::      
Human   940 ANYFFDAAKLMFKIADEEAKKGSKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKSSEATSAL 1004

  Fly  1012 --LLDSIALEDAAAI-ERLWHCAEAYHFMLLAQRQLRFGIVHSAVVTAVRLRDYEDVLPPEHIYS 1073
              ||:...|...... :..|..||||||.:||||||..|.|.:|:.||:.|:||||::||..|||
Human  1005 AGLLEEEVLSTTDRFTDNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYS 1069

  Fly  1074 LLALASCADRAFGTCSKAFMKLEQQAHLPEATLQRYEELAAGIFAKYDPEDTTGDRVDCYSCGVP 1138
            ||||.:||.||||||||||:||:....|.....|:||:||..||.|:..:|.....:|....|  
Human  1070 LLALCACASRAFGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEG-- 1132

  Fly  1139 VPDSSPSCPECNARFPACISSGKPITQPTNNIWICTTCHHCAAPTEISRHRTCPLCHS 1196
                      ...:.|.|:::|.|||:  ...|:|:.|.|.....|||.:..||||||
Human  1133 ----------GEGKLPTCVATGSPITE--YQFWMCSVCKHGVLAQEISHYSFCPLCHS 1178

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Oseg4NP_001261278.1 WD40 <7..217 CDD:225201 134/210 (64%)
WD40 <18..242 CDD:295369 134/226 (59%)
WD40 repeat 19..70 CDD:293791 32/50 (64%)
WD40 repeat 76..115 CDD:293791 26/38 (68%)
WD40 repeat 119..152 CDD:293791 26/32 (81%)
WD40 repeat 161..202 CDD:293791 22/41 (54%)
WD40 repeat 212..280 CDD:293791 34/69 (49%)
WD40 repeat 290..333 CDD:293791 25/42 (60%)
WD40 341..687 CDD:225201 145/365 (40%)
TPR repeat 815..838 CDD:276809 9/22 (41%)
TPR repeat 839..864 CDD:276809 7/24 (29%)
TPR repeat 869..894 CDD:276809 12/24 (50%)
YscO 877..980 CDD:284686 42/102 (41%)
DUF3505 1163..>1188 CDD:288836 9/24 (38%)
WDR35NP_001006658.1 WD 1 4..43 29/38 (76%)
WD40 <5..192 CDD:225201 127/187 (68%)
WD40 repeat 17..69 CDD:293791 33/52 (63%)
WD40 <19..184 CDD:295369 108/165 (65%)
WD 2 61..100 26/38 (68%)
WD40 repeat 75..113 CDD:293791 26/37 (70%)
WD 3 105..143 26/37 (70%)
WD40 repeat 118..190 CDD:293791 49/71 (69%)
WD 4 147..185 21/37 (57%)
WD 5 193..241 21/53 (40%)
WD40 repeat 206..251 CDD:293791 22/50 (44%)
WD 6 246..288 18/44 (41%)
WD40 repeat 256..300 CDD:293791 18/46 (39%)
WD40 repeat 306..345 CDD:293791 26/38 (68%)
Clathrin <829..920 CDD:279031 40/90 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159441
Domainoid 1 1.000 822 1.000 Domainoid score I64
eggNOG 1 0.900 - - E1_KOG2041
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H10814
Inparanoid 1 1.050 1096 1.000 Inparanoid score I238
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG56447
OrthoDB 1 1.010 - - D91334at33208
OrthoFinder 1 1.000 - - FOG0006996
OrthoInspector 1 1.000 - - oto89462
orthoMCL 1 0.900 - - OOG6_103988
Panther 1 1.100 - - LDO PTHR16517
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3735
SonicParanoid 1 1.000 - - X5088
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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