Protein Alignment Oseg4 and WDR35

DIOPT Version :10

• Sequence 1: NP_647653.1
• Gene: Oseg4 / 38219
• FlyBaseID: FBgn0035264
• Length: 1205
• Species: Drosophila melanogaster
• Sequence 2: NP_001006658.1
• Gene: WDR35 / 57539
• HGNCID: 29250
• Length: 1181
• Species: Homo sapiens
• Alignment Length: 1230
• Identity: 584/1230 - (47%)
• Similarity: 795/1230 - (64%)
• Gaps: 86/1230 - (6%)

  Fly     1 MFVYLSKKIAIPNNVKLNCIAWNKEEGYIAVAGTDGLLKVLKLDQATPNGQSKGGLAAVSNLSMN 65
            ||.||||||:|||||||.|::||||:|:||..|.|||||||||:..|.:.:.: ||||.||||||
Human     1 MFFYLSKKISIPNNVKLQCVSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLR-GLAAPSNLSMN 64

  Fly    66 QTLDGHKESVRVVTWNDAQQKLTSSDTDGVIMVWMLYKGSWYEEMTNDRKKSTVASMSWTSDGSR 130
            |||:||..||:|||||:..||||:||.:|:|:|||||||||.|||.|:|.||.|.||||.:||.:
Human    65 QTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRSMSWNADGQK 129

  Fly   131 ICIVYEDGAIIVGSVDGNRIFGKELKGTHLTGVQWSPDNRLILFALANGECHLYDNQGNFAMKLH 195
            |||||||||:||||||||||:||:|||..|:.|.||.|::::||.:||||.|:|||||||.:|:.
Human   130 ICIVYEDGAVIVGSVDGNRIWGKDLKGIQLSHVTWSADSKVLLFGMANGEIHIYDNQGNFMIKMK 194

  Fly   196 IQC-VNISGGSSSRGHRIASICWFSGR--VVQSRKRPVLAICYENGRVQIMRNENDDAPAIFDTG 257
            :.| ||::|..|     ||.|.|:.|.  .|:. ..|.||:|::|||.||||:|||..|.:.|||
Human   195 LSCLVNVTGAIS-----IAGIHWYHGTEGYVEP-DCPCLAVCFDNGRCQIMRHENDQNPVLIDTG 253

  Fly   258 MRNVDAKWNHDGTVLAICGTTLDAVSPTSQRDTNQVCFYSPLGKIYRTLKVPGTDITSLSWEGKS 322
            |..|..:|||.|:|||:.|....|:   ..:|.|.|.||:|.|:...||||||.:|::|||||..
Human   254 MYVVGIQWNHMGSVLAVAGFQKAAM---QDKDVNIVQFYTPFGEHLGTLKVPGKEISALSWEGGG 315

  Fly   323 LRIAMAVDSFIYFANIRPDYIWCYFEKTVVFLNSGSATR-ESPMSVITFWNTVSNQSFLKEVEPT 386
            |:||:|||||||||||||:|.|.|...|||:    :.|| :.|...:.||:|.:|:.::|.|:..
Human   316 LKIALAVDSFIYFANIRPNYKWGYCSNTVVY----AYTRPDRPEYCVVFWDTKNNEKYVKYVKGL 376

  Fly   387 LCLASSSEHCVLGVECVSSNIKEIALSTLENRSNPADDR-------VYQLLLCNSIGTTVDSKYT 444
            :.:.:..:.|:              |:|..:.::|.::.       .:.|:|||||||.:|.||.
Human   377 ISITTCGDFCI--------------LATKADENHPQEENEMETFGATFVLVLCNSIGTPLDPKYI 427

  Fly   445 DIRPCFVGINSSYVAIASQEEILIWHYHTPKSASTL---HNVKARKEKR---FHIDDTPTGVEMA 503
            ||.|.||.:..::|..||:|....|.|...|..:.|   ...::|||.|   :|:||||:|
Human   428 DIVPLFVAMTKTHVIAASKEAFYTWQYRVAKKLTALEINQITRSRKEGRERIYHVDDTPSG---- 488

  Fly   504 KDLMLSSSSG--DGHSTQRGISDPICALALSEKLLLVARESGAINEYSIANVALRNRHLMNAKVY 566
                  |..|  |...|.:|..|||||:..|:|:|:|.||||.|..||:.||.|..::.:|.:.|
Human   489 ------SMDGVLDYSKTIQGTRDPICAITASDKILIVGRESGTIQRYSLPNVGLIQKYSLNCRAY 547

  Fly   567 KMAINCNSTRAAIIDHMGVMTLLDLD----DNRETQL--NFSRVERKDVWAVSWATDNPLLLALM 625
            ::::||||:|.||||..||:|..|||    |:...|:  ...::||:|||.:.||.|||.|.|:|
Human   548 QLSLNCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVVGELLKLERRDVWDMKWAKDNPDLFAMM 612

  Fly   626 EKTRMYIFRGNDPEEPVSCSGYICTFEDLEITSVLLDDIISVGELQNFSHIIQLRVKSLRDTDDL 690
            ||||||:||..|||||:..|||||.||||||.|||||:|:...|..|..::|...::||||:..|
Human   613 EKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPNKDYLINFEIRSLRDSRAL 677

  Fly   691 LEHVGLEDAKQFIEDNPHPRLWRLLAESALKKLELETAENAFVRCAHYPGIKLVKRLRTIHSKEL 755
            :|.||::||.|||||||||||||||||:||:||:|.|||.|||||..|.|||.||||..:.|:.:
Human   678 IEKVGIKDASQFIEDNPHPRLWRLLAEAALQKLDLYTAEQAFVRCKDYQGIKFVKRLGKLLSESM 742

  Fly   756 QRAEISAFYGEFEEAEKLYLDADRRDLAIELRMTLCDWFRVVQLYRMGGSGVSDQQMEIAWREIG 820
            ::||:..::|.|||||:.||:.|||||||.||:.|.|||||:||.:.|.....|..:|.|...||
Human   743 KQAEVVGYFGRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQANNAIG 807

  Fly   821 HHFANLRSWESAREYYEKSHYLEGYMEALYHLEQFDDLEKCVERLPEKSPLLPKLAEMLASVGMC 885
            .:||:.:.|.:|.:||.:....|...|..|.||.::.||.....|||...|||::|:|...||||
Human   808 DYFADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAISLPENHKLLPEIAQMFVRVGMC 872

  Fly   886 SEAVQAHLRFGDQKAAVATCVNLRQWGEAVELAQRFQLPQVQTLIAKHAAQLLQEGRLKEAIEMQ 950
            .:||.|.|:....||||.|||:|.||.:|||||:...:.::.:|:|::|:.||::.:..:|||:.
Human   873 EQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELY 937

  Fly   951 RNAGRHLDAARLLSQMAEREQEKRAPLLRIKKLYVLAALLAEEHLKAVATTEIDYASGRNT---- 1011
            |.|....|||:|:.::|:.|.:|.:..||:||||||:|||.|::.:.:...:.....|:::
Human   938 RKANYFFDAAKLMFKIADEEAKKGSKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKSSEATS 1002

  Fly  1012 ----LLDSIALEDAAAI-ERLWHCAEAYHFMLLAQRQLRFGIVHSAVVTAVRLRDYEDVLPPEHI 1071
                ||:...|...... :..|..||||||.:||||||..|.|.:|:.||:.|:||||::||..|
Human  1003 ALAGLLEEEVLSTTDRFTDNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEI 1067

  Fly  1072 YSLLALASCADRAFGTCSKAFMKLEQQAHLPEATLQRYEELAAGIFAKYDPEDTTGDRVDCYSCG 1136
            ||||||.:||.||||||||||:||:....|.....|:||:||..||.|:..:|.....:|....|
Human  1068 YSLLALCACASRAFGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEG 1132

  Fly  1137 VPVPDSSPSCPECNARFPACISSGKPITQPTNNIWICTTCHHCAAPTEISRHRTCPLCHS 1196
                        ...:.|.|:::|.|||:  ...|:|:.|.|.....|||.:..||||||
Human  1133 ------------GEGKLPTCVATGSPITE--YQFWMCSVCKHGVLAQEISHYSFCPLCHS 1178

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oseg4	NP_647653.1	WD40	<18..318	CDD:441893	171/302 (57%)
		WD40 repeat	19..70	CDD:293791	32/50 (64%)
		WD40 repeat	76..115	CDD:293791	26/38 (68%)
		WD40 repeat	119..152	CDD:293791	26/32 (81%)
		WD40 repeat	161..202	CDD:293791	22/41 (54%)
		WD40 repeat	212..280	CDD:293791	34/69 (49%)
		WD40 repeat	290..333	CDD:293791	25/42 (60%)
		COG3899	<710..1118	CDD:443106	193/416 (46%)
WDR35	NP_001006658.1	WD 1	4..43		29/38 (76%)
		WD40 repeat	17..69	CDD:293791	33/52 (63%)
		WD40	<19..>184	CDD:441893	108/165 (65%)
		WD 2	61..100		26/38 (68%)
		WD40 repeat	75..113	CDD:293791	26/37 (70%)
		WD 3	105..143		26/37 (70%)
		WD40 repeat	118..190	CDD:293791	49/71 (69%)
		WD 4	147..185		21/37 (57%)
		WD 5	193..241		21/53 (40%)
		WD40 repeat	206..251	CDD:293791	22/50 (44%)
		WD 6	246..288		18/44 (41%)
		WD40 repeat	256..300	CDD:293791	18/46 (39%)
		WD40 repeat	306..345	CDD:293791	26/38 (68%)
		LapB	<690..881	CDD:442196	98/190 (52%)
		LapB	832..>940	CDD:442196	46/107 (43%)