DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oseg4 and TULP4

DIOPT Version :9

Sequence 1:	NP_001261278.1	Gene:	Oseg4 / 38219	FlyBaseID:	FBgn0035264	Length:	1205	Species:	Drosophila melanogaster
Sequence 2:	XP_011534248.1	Gene:	TULP4 / 56995	HGNCID:	15530	Length:	1566	Species:	Homo sapiens

Alignment Length:	1504	Identity:	286/1504 - (19%)
Similarity:	458/1504 - (30%)	Gaps:	546/1504 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LSKKIAIPNNVKLNCIAWNK--EEGYIAVAGTDGLLKV------LKLDQATPNGQSKGGLAAVSN 61
            ||.|..:|.:.|...:...:  |||::|.....|::.|      .:.|::||.
Human    20 LSWKGRVPKSEKEKPVCRRRYYEEGWLATGNGRGVVGVTFTSSHCRRDRSTPQ------------ 72

  Fly    62 LSMNQTLDGHKESVRVVTWNDAQQKLTSSDTDGVIMVWMLYKGSWYEEMTNDRKKSTVASMSWTS 126
             .:|..|.||...|.:|.||:..|||.:.|.||.|.||:.|:|.|..|:.||| .:.|:..:|:.
Human    73 -RINFNLRGHNSEVVLVRWNEPYQKLATCDADGGIFVWIQYEGRWSVELVNDR-GAQVSDFTWSH 135

  Fly   127 DGSRICIVYEDGAIIVGSVDGNRIFGKELK-GTHLTGVQWSPDNRLILFALANG-----ECH--- 182
            ||::..|.|.||.::||||.|.|.:..|:. .:.:|...|:||::.:||..|:|     :||
Human   136 DGTQALISYRDGFVLVGSVSGQRHWSSEINLESQITCGIWTPDDQQVLFGTADGQVIVMDCHGRM 200

  Fly   183 -----LYDNQGNFAMKLHIQCVNISGGSSS-----------RGHRIASICWFSGRVVQSRKRPVL 231
                 |:::.|...|..:.....:...|.|           .|.....|      .||:.| |:|
Human   201 LAHVLLHESDGVLGMSWNYPIFLVEDSSESDTDSDDYAPPQDGPAAYPI------PVQNIK-PLL 258

  Fly   232 AICYENGRVQIMRNENDDAPAIFDTGMRNVDAKWNHDGTVLAICG----TTLDAVSPTSQRDTNQ 292
            .:.:.:|.:.:|.|.:|.:|.:..:|::.|.|:|...|.:||:.|    |.|..:.......:..
Human   259 TVSFTSGDISLMNNYDDLSPTVIRSGLKEVVAQWCTQGDLLAVAGMERQTQLGELPNGPLLKSAM 323

  Fly   293 VCFYSPLGKIYRTLKV-----------------PGTD-------ITSLSWEGKSLRIAMAVDSFI 333
            |.||:..|:...||..                 |..|       |.|:.|..:..|:.||....:
Human   324 VKFYNVRGEHIFTLDTLVQISLRPCFSSLLDLCPEVDLLDHMRPIISICWGHRDSRLLMASGPAL 388

  Fly   334 YFANI--RPDYIWCYFEKTVVFLNSGSATRES--------PMSVITFWNTVSNQSFLKEVEPTL- 387
            |...:  |...:....::.:     .|..||.        |..:.::.:|    :|:..::|.:
Human   389 YVVRVEHRVSSLQLLCQQAI-----ASTLREDKDVSKLTLPPRLCSYLST----AFIPTIKPPIP 444

  Fly   388 ------------CLASSSEHCVL---------GVECVSSNIKEIA----------LSTL------ 415
                        ...:...||.:         |..|.:..::.:.          :|.|
Human   445 DPNNMRDFVSYPSAGNERLHCTMKRTEDDPEVGGPCYTLYLEYLGGLVPILKGRRISKLRPEFVI 509

  Fly   416 -ENRSNPADDRVYQLLLCNSIGTTV-------DSKYTDIRPCFVGINSSYVAIASQE----EILI 468
             :.|::...|.:|.    ||:.:||       ||...::...:....|..::.||:.    .|.|
Human   510 MDPRTDSKPDEIYG----NSLISTVIDSCNCSDSSDIELSDDWAAKKSPKISRASKSPKLPRISI 570

  Fly   469 WHYHTPK----------------------SAS-----------TLHNVKAR-------------- 486
            ....:||                      |.|           |.||..|:
Human   571 EARKSPKLPRAAQELSRSPRLPLRKPSVGSPSLTRREFPFEDITQHNYLAQVTSNIWGTKFKIVG 635

  Fly   487 --------------KEKRFHIDDTPTGV---EMAK---------------------DLMLSSSSG 513
                          |....|:......:   |:.|                     ||.::.:||
Human   636 LAAFLPTNLGAVIYKTSLLHLQPRQMTIYLPEVRKISMDYINLPVFNPNVFSEDEDDLPVTGASG 700

  Fly   514 -DGHSTQRGISDPICALALSEKLLLVARESGAINEYSIANVALRNRHLMNAKVYKMAINCNSTRA 577
             ..:|....::.||..:..|.:.:...:..|.:...           |.|..|....:...:|..
Human   701 VPENSPPCTVNIPIAPIHSSAQAMSPTQSIGLVQSL-----------LANQNVQLDVLTNQTTAV 754

  Fly   578 AIIDHMGVMTLLDLDDNRET---QLNFSRVERKDVWAVSWATDNPLLLALMEKTRMYIFRGNDPE 639
            ...:|.|.........||.:   |:.|..||...:      ..||..|:|..          .|:
Human   755 GTAEHAGDSATQYPVSNRYSNPGQVIFGSVEMGRI------IQNPPPLSLPP----------PPQ 803

  Fly   640 EPVSCSGYICTFEDLEITSVLLDDIISVGELQNFSHIIQLRVKSLRDTDDLLEH-----VGLEDA 699
            .|:..|                    :||........:|...|:||.|..|...     ......
Human   804 GPMQLS--------------------TVGHGDRDHEHLQKSAKALRPTPQLAAEGDAVVFSAPQE 848

  Fly   700 KQFIEDNPHPRLWRLL-------------------AESALKKLELETAENAFVRCAHYPGIKLVK 745
            .|..:.||.|.....:                   .:..|||.:.    :.:....||......:
Human   849 VQVTKINPPPPYPGTIPAAPTTAAPPPPLPPPQPPVDVCLKKGDF----SLYPTSVHYQTPLGYE 909

  Fly   746 RLRTIHSKELQRAEISAFYGEFEEAEKLYLDADRRDLAIELRMTLCDWFRVVQLYRMGGSGVSDQ 810
            |:.|..|.           |..||.           .....|| ||.    ...|.:.|.|.|
Human   910 RITTFDSS-----------GNVEEV-----------CRPRTRM-LCS----QNTYTLPGPGSS-- 945

  Fly   811 QMEIAWREIGHHFANLRSWESAREYYEKSHYLEGYMEALYHLEQFDDLEKCVERLPEKSPLLPKL 875
                         |.||                              |....:::|:.
Human   946 -------------ATLR------------------------------LTATEKKVPQP------- 960

  Fly   876 AEMLASVGMCSEAVQAHLRFGDQKAAVATCVNLRQWGEAVELAQRFQLPQVQTLIAKHAAQLLQE 940
                     ||.|....|                       ...|:.:|..........|..|.:
Human   961 ---------CSSATLNRL-----------------------TVPRYSIPTGDPPPYPEIASQLAQ 993

  Fly   941 GRLKEAIEMQRNAGRHLDAAR----LLSQMAEREQEKRAPLLRIKK------------------- 982
            ||  .|.:...|:..|....|    ...:||:.....||||..:.|
Human   994 GR--GAAQRSDNSLIHATLRRNNREATLKMAQLADSPRAPLQPLAKSKGGPGGVVTQLPARPPPA 1056

  Fly   983 LYV----------------LAALLAEEHLKAVATTEI----DYASGRNTLLDSIALEDAAAIERL 1027
            ||.                ||...:...|.:.::..:    |.|..|...::|...||.|..:
Human  1057 LYTCSQCSGTGPSSQPGASLAHTASASPLASQSSYSLLSPPDSARDRTDYVNSAFTEDEALSQ-- 1119

  Fly  1028 WHCAEAYHFMLLAQRQLRFGIVHSAVVTAVRLRDY-------EDVLPPEHIYSLLALASCADRAF 1085
             ||.        .::.||...:..|.||..|...|       |||..|:            :|..
Human  1120 -HCQ--------LEKPLRHPPLPEAAVTLKRPPPYQWDPMLGEDVWVPQ------------ERTA 1163

  Fly  1086 GTCSKAFMK-----LEQQAHLPEATLQRYEELAAGIFAKYDPEDTTGDRVDCYSCGVPVPDS--- 1142
            .|.....:|     |.|..||..:.|.        ..:...|...|......|..|||.|.|
Human  1164 QTSGPNPLKLSSLMLSQGQHLDVSRLP--------FISPKSPASPTATFQTGYGMGVPYPGSYNN 1220

  Fly  1143 -------SPSCPECNARFPACISSGKP--ITQP--TNNIWICT---------TCHHCAAPTEI-- 1185
                   :|..|: :|..|...:..:|  :.||  ..::..||         ||.....|...
Human  1221 PPLPGVQAPCSPK-DALSPTQFAQQEPAVVLQPLYPPSLSYCTLPPMYPGSSTCSSLQLPPVALH 1284

  Fly  1186 --SRHRTCP 1192
              |.:..||
Human  1285 PWSSYSACP 1293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oseg4	NP_001261278.1	WD40	<7..217	CDD:225201	68/242 (28%)
		WD40	<18..242	CDD:295369	71/256 (28%)
		WD40 repeat	19..70	CDD:293791	11/58 (19%)
		WD40 repeat	76..115	CDD:293791	18/38 (47%)
		WD40 repeat	119..152	CDD:293791	14/32 (44%)
		WD40 repeat	161..202	CDD:293791	13/53 (25%)
		WD40 repeat	212..280	CDD:293791	20/71 (28%)
		WD40 repeat	290..333	CDD:293791	14/66 (21%)
		WD40	341..687	CDD:225201	73/492 (15%)
		TPR repeat	815..838	CDD:276809	3/22 (14%)
		TPR repeat	839..864	CDD:276809	1/24 (4%)
		TPR repeat	869..894	CDD:276809	3/24 (13%)
		YscO	877..980	CDD:284686	20/106 (19%)
		DUF3505	1163..>1188	CDD:288836	8/39 (21%)
TULP4	XP_011534248.1	WD40	<67..>218	CDD:225201	55/164 (34%)
		WD40	78..>213	CDD:295369	50/135 (37%)
		WD40 repeat	85..123	CDD:293791	17/37 (46%)
		WD40 repeat	129..166	CDD:293791	14/36 (39%)
		WD40 repeat	171..205	CDD:293791	10/33 (30%)
		SOCS	396..431	CDD:295349	5/39 (13%)
		Tub	<611..>669	CDD:279506	7/57 (12%)
		Tub	<1489..1559	CDD:279506
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D91334at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910