DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oseg4 and tulp4a

DIOPT Version :9

Sequence 1:	NP_001261278.1	Gene:	Oseg4 / 38219	FlyBaseID:	FBgn0035264	Length:	1205	Species:	Drosophila melanogaster
Sequence 2:	XP_005168569.1	Gene:	tulp4a / 557730	ZFINID:	ZDB-GENE-060503-215	Length:	1736	Species:	Danio rerio

Alignment Length:	1274	Identity:	248/1274 - (19%)
Similarity:	449/1274 - (35%)	Gaps:	361/1274 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFVYLSKKIAIPNNVKLNCIAWNK-----------------EEGYIAVAGTDGLLKV------LK 42
            ||..:.....:.::..:.|::|..                 |||::|.....|::.|      .:
Zfish     1 MFAAVEHGPVLCSDSNILCLSWKGRVPRSQKEKPVCRRRYCEEGWLATGNGRGVVGVTFTSSHCR 65

  Fly    43 LDQATPNGQSKGGLAAVSNLSMNQTLDGHKESVRVVTWNDAQQKLTSSDTDGVIMVWMLYKGSWY 107
            .|:.||.             .:|..|.||...|.:|.||:..|||.:.||||.|.||:.|:|.|.
Zfish    66 RDRNTPQ-------------RINFNLRGHNSEVVLVRWNEPFQKLATCDTDGGIFVWIQYEGRWS 117

  Fly   108 EEMTNDRKKSTVASMSWTSDGSRICIVYEDGAIIVGSVDGNRIFGKELK-GTHLTGVQWSPDNRL 171
            .|:.||| .:.|:..:|:.||::..|.|.||.::||||.|.|.:..|:. .:.:|...|:||::.
Zfish   118 VELVNDR-GAQVSDFTWSHDGTQALISYRDGFVLVGSVSGQRHWSSEINLESQITCGIWTPDDQQ 181

  Fly   172 ILFALANGECHLYDNQGNFAMKLHIQCVNISGGSSSRGHRIASICW-FSGRVVQSRK-------- 227
            :||..|:|:..:.|..|.  |..||......|        |||:.| :...:|:...
Zfish   182 VLFGTADGQVIVMDCHGR--MLAHILLHEAEG--------IASMAWNYPSFLVEDSSESDSDSDD 236

  Fly   228 ---------RPVLAICYENGRVQIMRNENDDAPAIFDTGMRNVDAKWNHDGTVLAICGTTLDAVS 283
                     :|:|.:|:.:|.:.:|.|.:|.:|.:..||:::|..:|:..|.:||:.|......|
Zfish   237 STPPQVHTLKPLLTVCFTSGDISLMSNYDDLSPLLIRTGLKDVVVQWSSQGDLLAVAGMERLVTS 301

  Fly   284 PTSQRDTNQVC-FYSPLGKIYRTLKVPG-TDITSLSWEGKSLRIAMAVDSFIYFANI--RPDYIW 344
            ..:|...|.:. ||:..|:...:|:.|. ..|::|.|..:..|:.:|....:|...:  |...:.
Zfish   302 DPTQATRNAIVKFYNVRGEHIYSLETPAQRPISTLCWGHRDSRVFLACGPALYVLRVEHRVSSLQ 366

  Fly   345 CYFEKTVVFLNSGSATRE----SPMSVITFWNTVSNQSFLKEVEPTL-----------CLASSSE 394
            ...::.:     .||..|    :.:|:.:..:|..:.:|...::|.:           ...|.:|
Zfish   367 LLCQQAI-----ASAVHEEKDLAKLSMPSRLSTYVSSAFAPTIKPPIPDPNNMRDFVSYPTSGNE 426

  Fly   395 --HCVL---------GVECVSSNIKEIA----------LSTL-------ENRSNPADDRVY---- 427
              ||.:         |..|.:..::.:.          :|.|       :.:::...|.||
Zfish   427 RLHCTMKRTEDNPEVGGPCYTLYLEYLGGLVPILKGRRISKLRPEFVIMDPKTDGKTDEVYGNSF 491

  Fly   428 ---QLLLCNSIGTTVDSKYTDIRPCFVGINSSYVAIASQEEILIWHYHTPKSASTLHNVKARKEK 489
               .:..||    ..||...::...:||..|..::..|:         :||
Zfish   492 IPSMIDSCN----CSDSSDIELNDDWVGKKSPKISRGSK---------SPK-------------- 529

  Fly   490 RFHIDDTPTGVEMAKDLMLSSSSGDGHSTQRGISDPICALALSEKLLLVARESG-AINEYSIANV 553
                        :.:||:..       .|.|...||..:..||.....::|... .|.:.||.:.
Zfish   530 ------------LPRDLVCP-------FTNRINIDPRKSPKLSRTTQEISRSPRLPIRKPSIGSP 575

  Fly   554 ALRNRHLMNAKVYKMAINCNSTRAAIIDHMGVMTLLDLDDNRETQLNFSRVERKDVWA-----VS 613
            :|..|.                             ..|||  .||.|:......::|.     |.
Zfish   576 SLTRRE-----------------------------FPLDD--ITQHNYLAQVTSNIWGTKFKIVG 609

  Fly   614 WATDNPLLL-ALMEKTRMYIFRGNDPEEPVSCSGYICTFEDLEITSVLLDDIISVGELQNFSHII 677
            .|...|..| |::.||.:...      :|...:.|:     .|:..:.::.|    .|..||..:
Zfish   610 LAAFLPTNLGAVIYKTSLLHL------QPRQMTIYL-----PEVRKISVEYI----NLPMFSPNV 659

  Fly   678 QLRVKSLRDTDDLLEHVGLEDAKQFIEDNP-----------HPRLWRL-------LAESAL--KK 722
                 ...|.|||    .:..|....:|||           |.....:       |.:|.|  :.
Zfish   660 -----FSEDEDDL----PVTGASGITDDNPPCTVNIPIAPIHSPAQAMSPTQSIGLVQSLLANQN 715

  Fly   723 LELETAENAFVRCAHYPGIKLVKRLRTIHSKELQRAEISAFYGEFEEAEKLYLDADRRDLAIELR 787
            ::|:...|.....|. ||:.                                 |..:.|..:..:
Zfish   716 VQLDVLSNPTSTVAP-PGVS---------------------------------DQGQHDTVLTAQ 746

  Fly   788 MTLCDWFRVVQLYRMGGSGV---------SDQQMEIAWREIGHHFANLRSWESAREYYEKSHYLE 843
            .|:...:........||..|         ..||.....:::..|:...:..:..::|..:...|.
Zfish   747 YTVPARYSSPGQVIFGGMDVGRLLVAQSQQQQQQSQQHQQLQQHYQQQQLQQQLQQYQLQQQQLL 811

  Fly   844 GYMEALYHLEQFDD--LEKCVERLPEKSPLLPKLAEMLASVGMCSEAVQAHLRFGDQKAAVATCV 906
            .:.    |::|...  :::.::::.::..:..:|...:.         |.||:...|       :
Zfish   812 QHQ----HMQQQQQQHMQQQIQQMQQQQQMQQQLQHQIQ---------QQHLQMQLQ-------L 856

  Fly   907 NLRQWGEAVELAQRFQLPQVQTLIAKHAA----QLLQEGRLKEA--IEMQRNAGRH-----LDAA 960
            ..:|..:.::...:.|:| |.||.:...:    ||.|......|  .|.....|.|     :...
Zfish   857 QHQQMQQQLQQQHQMQIP-VPTLPSGQPSCPVIQLPQSTIPVAAPTAEHSTERGEHELLLKIKTT 920

  Fly   961 RLLSQMAEREQEKRAPLLRIKKL--------YVLAALLAEEHLKAVATTEIDYASGRNTLLDSIA 1017
            |...|:||.:.......|.|.|:        .|.||:       |.||..:..|:..::...::.
Zfish   921 RSAPQLAEGDAVVFTAPLEISKMNPPPPYPGTVAAAV-------AAATAAVSAAASASSTSGAVG 978

  Fly  1018 LEDAAAIERLWHCAEAYHFMLL------AQRQLRFGIVHSAVVTAVRLRDYEDVLPP-------E 1069
            ...:.:... ..|.:.....|.      ||.....|  :..:.|.....:.|:|..|       :
Zfish   979 SSSSTSSSG-EVCLKKGDLTLYPPSAQGAQYPTPLG--YERITTFDSSGNVEEVCRPRTRLVCNQ 1040

  Fly  1070 HIYSLLALASCADRAFGTCSKAFMKLEQQAHLPEATLQR 1108
            ::|:|....|.|.....:.|.|....:.|.....|||.|
Zfish  1041 NVYTLQGPGSSATLRVSSSSSAVEGKKVQLPYASATLNR 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oseg4	NP_001261278.1	WD40	<7..217	CDD:225201	68/233 (29%)
		WD40	<18..242	CDD:295369	74/265 (28%)
		WD40 repeat	19..70	CDD:293791	13/73 (18%)
		WD40 repeat	76..115	CDD:293791	19/38 (50%)
		WD40 repeat	119..152	CDD:293791	14/32 (44%)
		WD40 repeat	161..202	CDD:293791	13/40 (33%)
		WD40 repeat	212..280	CDD:293791	21/85 (25%)
		WD40 repeat	290..333	CDD:293791	11/44 (25%)
		WD40	341..687	CDD:225201	63/402 (16%)
		TPR repeat	815..838	CDD:276809	2/22 (9%)
		TPR repeat	839..864	CDD:276809	3/26 (12%)
		TPR repeat	869..894	CDD:276809	3/24 (13%)
		YscO	877..980	CDD:284686	22/113 (19%)
		DUF3505	1163..>1188	CDD:288836
tulp4a	XP_005168569.1	WD40	48..>398	CDD:225201	100/378 (26%)
		WD40	78..>193	CDD:295369	47/115 (41%)
		WD40 repeat	85..123	CDD:293791	18/37 (49%)
		WD40 repeat	129..166	CDD:293791	14/36 (39%)
		WD40 repeat	171..205	CDD:293791	12/35 (34%)
		WD40 repeat	213..272	CDD:293791	12/58 (21%)
		WD40 repeat	279..326	CDD:293791	12/46 (26%)
		WD40 repeat	333..358	CDD:293791	6/24 (25%)
		Tub	<585..>643	CDD:279506	16/70 (23%)
		Tub	<1659..1729	CDD:279506
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D91334at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910