DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oseg4 and Wdr35

DIOPT Version :9

Sequence 1:	NP_001261278.1	Gene:	Oseg4 / 38219	FlyBaseID:	FBgn0035264	Length:	1205	Species:	Drosophila melanogaster
Sequence 2:	XP_006239947.1	Gene:	Wdr35 / 503018	RGDID:	1564116	Length:	1181	Species:	Rattus norvegicus

Alignment Length:	1232	Identity:	587/1232 - (47%)
Similarity:	791/1232 - (64%)	Gaps:	86/1232 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFVYLSKKIAIPNNVKLNCIAWNKEEGYIAVAGTDGLLKVLKLDQATPNGQSKGGLAAVSNLSMN 65
            ||.|||||||:||||||.||:|||::|:||..|.|||||||:|:..|.:.:.: ||||.||||||
  Rat     1 MFFYLSKKIAVPNNVKLKCISWNKDQGFIACGGEDGLLKVLRLETQTDDSKLR-GLAAPSNLSMN 64

  Fly    66 QTLDGHKESVRVVTWNDAQQKLTSSDTDGVIMVWMLYKGSWYEEMTNDRKKSTVASMSWTSDGSR 130
            |.|:||..:|:|||||:..||||:||.:|:|:|||||||||||||.|:|.||.|.||||.:||.:
  Rat    65 QNLEGHSGAVQVVTWNEQYQKLTTSDQNGLIIVWMLYKGSWYEEMINNRNKSVVRSMSWNADGQK 129

  Fly   131 ICIVYEDGAIIVGSVDGNRIFGKELKGTHLTGVQWSPDNRLILFALANGECHLYDNQGNFAMKLH 195
            |||||||||:||||||||||:||:|||..|..|.||.|::::||.:||||.|:|||||||.||:.
  Rat   130 ICIVYEDGAVIVGSVDGNRIWGKDLKGIQLCHVTWSADSKILLFGMANGEIHIYDNQGNFIMKMK 194

  Fly   196 IQC-VNISGGSSSRGHRIASICWFSGR--VVQSRKRPVLAICYENGRVQIMRNENDDAPAIFDTG 257
            :.| ||::|..|     ||.|.|:.|.  .|:. ..|.||||::|||.||||:|||..|.:.|||
  Rat   195 LNCLVNVTGAIS-----IAGIHWYHGTEGYVEP-DCPCLAICFDNGRCQIMRHENDQNPVLIDTG 253

  Fly   258 MRNVDAKWNHDGTVLAICGTTLDAVSPTSQRDTNQVCFYSPLGKIYRTLKVPGTDITSLSWEGKS 322
            |..|..:|||.|:|||:.|:....   |..:|.|.|.||:|.|:...||||||..:.||||||..
  Rat   254 MYVVGIQWNHIGSVLAVAGSQKVV---TQDKDVNIVQFYTPFGEHLGTLKVPGKQMCSLSWEGGG 315

  Fly   323 LRIAMAVDSFIYFANIRPDYIWCYFEKTVVFLNSGSATR-ESPMSVITFWNTVSNQSFLKEVEPT 386
            |:||:|||||||||||||||.|.|...|||:    :.|| :.|...:.||:|.:|:.::|.|:..
  Rat   316 LKIALAVDSFIYFANIRPDYKWGYCSNTVVY----AYTRPDRPEYCVVFWDTKNNEKYVKYVKSL 376

  Fly   387 LCLASSSEHCVLGVECVSSNIKEIALSTLENRSNPADDR-------VYQLLLCNSIGTTVDSKYT 444
            :.:.:..:.|:              |:|..:.::|.::.       .:.|:|||||||.:|.||.
  Rat   377 ISITTCGDFCI--------------LATKADENHPQEENEMETFGATFVLVLCNSIGTPLDPKYI 427

  Fly   445 DIRPCFVGINSSYVAIASQEEILIWHYHTPKSASTL---HNVKARKEKR---FHIDDTPTGVEMA 503
            |:.|.||.:..::|..||:|.:..|.|...|..:.|   ...::|||.|   :|:||.|:|
  Rat   428 DLVPLFVAMTKTHVIAASKEALYTWQYRVAKKLTALEINQITRSRKEGRERIYHVDDVPSG---- 488

  Fly   504 KDLMLSSSSG--DGHSTQRGISDPICALALSEKLLLVARESGAINEYSIANVALRNRHLMNAKVY 566
                  |..|  |.....:|..|||||:..|:|.|:|.||||.|..||..||||..::.::.:..
  Rat   489 ------SVDGVFDYSKAIQGTRDPICAITASDKTLIVGRESGVIQRYSFPNVALIQKYSLDCRAC 547

  Fly   567 KMAINCNSTRAAIIDHMGVMTLLDLD----DNRETQL--NFSRVERKDVWAVSWATDNPLLLALM 625
            ::::||||:|.||||..||:|..|||    |:...|:  ...::||||||.:.||.|||.|.|:|
  Rat   548 QLSLNCNSSRLAIIDIAGVLTFFDLDTRVTDSTGQQVVGELLKLERKDVWDMKWAKDNPDLFAMM 612

  Fly   626 EKTRMYIFRGNDPEEPVSCSGYICTFEDLEITSVLLDDIISVGELQNFSHIIQLRVKSLRDTDDL 690
            ||||||:||..|||||:..|||||.||||||.|||||:|:...|..:..:|:...::||||:..|
  Rat   613 EKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKNPEHPSKDYIMNFEIRSLRDSRAL 677

  Fly   691 LEHVGLEDAKQFIEDNPHPRLWRLLAESALKKLELETAENAFVRCAHYPGIKLVKRLRTIHSKEL 755
            :|.||:|||.|||||||||||||||||:||:||:|.||:.|||||..|.|||.||||..:.|:.:
  Rat   678 IEKVGIEDASQFIEDNPHPRLWRLLAEAALQKLDLYTAQQAFVRCKDYQGIKFVKRLGNLQSESM 742

  Fly   756 QRAEISAFYGEFEEAEKLYLDADRRDLAIELRMTLCDWFRVVQLYRMGGSGVSDQQMEIAWREIG 820
            ::||:.|::|.|||||::|||.|||||||.||:.|.|||||:||.:.|.....|..:|.|...||
  Rat   743 KQAEVIAYFGRFEEAERMYLDMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQAHNAIG 807

  Fly   821 HHFANLRSWESAREYYEKSHYLEGYMEALYHLEQFDDLEKCVERLPEKSPLLPKLAEMLASVGMC 885
            .:||:.:.|.:|.:||.|....|...|..|.||.::.||.....|||...|||::|:|...||||
  Rat   808 DYFADRQKWMNAVQYYVKGRNQERLAECYYMLEDYEGLENLANSLPENHKLLPEIAQMFVRVGMC 872

  Fly   886 SEAVQAHLRFGDQKAAVATCVNLRQWGEAVELAQRFQLPQVQTLIAKHAAQLLQEGRLKEAIEMQ 950
            .:||.|.|:....||||.|||:|.||.:|||||:...:.::.:|:|::|:.||::.:..:|||:.
  Rat   873 EQAVSAFLKCNQPKAAVDTCVHLNQWNKAVELAKSHSMKEIGSLLARYASHLLEKNKTLDAIELY 937

  Fly   951 RNAGRHLDAARLLSQMAEREQEKRAPLLRIKKLYVLAALLAEEHLKAVATTEIDYASGRNT---- 1011
            |.|....|||:|:.::|:.|.:||...||:||||||:|||.|::.:.:...:.....|:|:
  Rat   938 RKASYFFDAAKLMYKIADEEAKKRTKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKNSEATS 1002

  Fly  1012 ----LLDSIALEDAAAI-ERLWHCAEAYHFMLLAQRQLRFGIVHSAVVTAVRLRDYEDVLPPEHI 1071
                ||:...|...:.. :..|..||||||.:||||||..|.|.:|:.||:.||||||::|...|
  Rat  1003 ALAGLLEEEVLSTTSRFTDNAWRGAEAYHFFILAQRQLYEGYVDTALKTALHLRDYEDIIPSVEI 1067

  Fly  1072 YSLLALASCADRAFGTCSKAFMKLEQQAHLPEATLQRYEELAAGIFAKYDPEDTTGDRVDCYSCG 1136
            ||||||.:||.||||||||||:|||....|.....|:||:||..||.|:.|:|.....::....|
  Rat  1068 YSLLALCACASRAFGTCSKAFIKLESLETLSAEQKQQYEDLALEIFTKHTPKDNRKSELNSLLEG 1132

  Fly  1137 VPVPDSSPSCPECNARFPACISSGKPITQPTNNIWICTTCHHCAAPTEISRHRTCPLCHSLI 1198
                        ...:.|.||::|.||.:  ...|:|..|.|.....|||.:..||||||.:
  Rat  1133 ------------GEGKLPTCIATGSPIIE--YQFWVCKVCKHYVLAQEISNYNFCPLCHSSV 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oseg4	NP_001261278.1	WD40	<7..217	CDD:225201	133/210 (63%)
		WD40	<18..242	CDD:295369	134/226 (59%)
		WD40 repeat	19..70	CDD:293791	30/50 (60%)
		WD40 repeat	76..115	CDD:293791	27/38 (71%)
		WD40 repeat	119..152	CDD:293791	26/32 (81%)
		WD40 repeat	161..202	CDD:293791	23/41 (56%)
		WD40 repeat	212..280	CDD:293791	35/69 (51%)
		WD40 repeat	290..333	CDD:293791	25/42 (60%)
		WD40	341..687	CDD:225201	142/367 (39%)
		TPR repeat	815..838	CDD:276809	9/22 (41%)
		TPR repeat	839..864	CDD:276809	7/24 (29%)
		TPR repeat	869..894	CDD:276809	12/24 (50%)
		YscO	877..980	CDD:284686	43/102 (42%)
		DUF3505	1163..>1188	CDD:288836	8/24 (33%)
Wdr35	XP_006239947.1	WD40	<7..217	CDD:225201	135/215 (63%)
		WD40 repeat	18..69	CDD:293791	30/51 (59%)
		WD40 repeat	74..111	CDD:293791	27/36 (75%)
		WD40 repeat	205..251	CDD:293791	23/51 (45%)
		WD40 repeat	256..300	CDD:293791	18/46 (39%)
		WD40 repeat	308..345	CDD:293791	27/36 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353486
Domainoid	1	1.000	822	1.000	Domainoid score	I61
eggNOG	1	0.900	-	-		E1_KOG2041
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10814
Inparanoid	1	1.050	1101	1.000	Inparanoid score	I219
OMA	1	1.010	-	-		QHG56447
OrthoDB	1	1.010	-	-		D91334at33208
OrthoFinder	1	1.000	-	-		FOG0006996
OrthoInspector	1	1.000	-	-		oto96588
orthoMCL	1	0.900	-	-		OOG6_103988
Panther	1	1.100	-	-	LDO	PTHR16517
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5088
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810