DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oseg4 and ifta-1

DIOPT Version :9

Sequence 1:	NP_001261278.1	Gene:	Oseg4 / 38219	FlyBaseID:	FBgn0035264	Length:	1205	Species:	Drosophila melanogaster
Sequence 2:	NP_508940.4	Gene:	ifta-1 / 183817	WormBaseID:	WBGene00016935	Length:	1246	Species:	Caenorhabditis elegans

Alignment Length:	1283	Identity:	382/1283 - (29%)
Similarity:	621/1283 - (48%)	Gaps:	149/1283 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFVYLSKKIAIPNNVKLNCIAWNKEEGYIAVAGTDGLLKVLKL-DQATPNGQSKGGLAAVSNLSM 64
            |.|:....:.:|.:.:|:...||....|||..|..|.|||:|: ..||...:|..    .:.|.:
Worm    21 MSVFRKFNLGLPEHGQLHFAEWNYNSNYIACGGALGKLKVVKIGTDATDLNKSPN----AATLVV 81

  Fly    65 NQTLDGHKESVRVVTWNDAQQKLTSSDTDGVIMVWMLYKGSWYEEMTNDRKKSTVASMSWTSDGS 129
            ||.|:||..:|...|||:..||||:|||.|:|:||.::...|.|||.|:|.||.|.|:.|..:|:
Worm    82 NQALEGHNATVMNATWNENNQKLTTSDTSGLIIVWGMFNEQWCEEMINNRNKSVVVSICWNLEGT 146

  Fly   130 RICIVYEDGAIIVGSVDGNRIFGKELKGTHLTGVQWSPDNRLILFALANGECHLYDNQGNFAMKL 194
            :|.|.|.||.:|||:::||||:.|||: ..|...:|:||..:::|..|:|:..::|:.|:..:.:
Worm   147 KIAIAYADGNVIVGTLEGNRIWNKELE-IQLAACEWAPDGDMLIFGTADGKVSVFDDSGSHFLDI 210

  Fly   195 HIQCV---NISGGSSSRGHRIASI-C---W----------------FSGRVVQSRK--------- 227
            .:.|:   ::....:.:.|:...| |   |                |..::.:.|:
Worm   211 PMHCLEAEDLEQALAKKEHQKEEIVCLKYWSPTLKSKTILDEMERDFERKLEKDREVTGTAIFTN 275

  Fly   228 --------------------------RPVLAICYENGRVQIMRNENDDAPAIFD-TGMRNVDAKW 265
                                      ||...:.|..|.:|:||:.||..|.:.. ...:...|||
Worm   276 FPTKPPPKELPEHEKNTEPYQPVPPDRPRFVVAYARGMMQLMRSLNDPEPVVVSIPNFKITGAKW 340

  Fly   266 NHDGTVLAICGTTLDAVSPTSQRDTNQVCFYSPLGKIYRTLKVPGTDITSLSWEGKSLRIAMAVD 330
            :.:|..||:||...|...||    .:::.|.|..|.|....:...:.||.:.||...||:|:|..
Worm   341 SPNGAFLAVCGNDSDKDEPT----FSKIHFLSAYGHIVGYFQTNDSCITGICWESTGLRMAIAAA 401

  Fly   331 SFIYFANIRPDYIWCYFEKTVVFLNSGSATRESPMSVITFWNTVSNQSFLKEVEPTLCLASSSEH 395
            ..:....|||::.|...|:|:|::..   ..|.....|.|::..:::..:|.|.....:|...||
Worm   402 GTLLIGQIRPEFKWGSIEETIVYVYQ---KEELYQYGIMFYDYKTDEKTVKTVTHFENMAFYREH 463

  Fly   396 CVLGVECVSSNIKEIALSTLENRSNPADDRV---YQLLLCNSIGTTVDSKYTDIRPCFVGINSSY 457
            |||                    .|..||.|   |...|||||||::|...|.:||.|..:|...
Worm   464 CVL--------------------INRQDDGVIPHYFCQLCNSIGTSLDYNVTTVRPKFACVNGIC 508

  Fly   458 VAIASQEEILIWHYHTPKSASTLHNVKARKEKRFHIDDTPTGVEMAKDLMLSSSSGD-------- 514
            ..|||::...|||:..||    .::|:|             |:.      :...|||
Worm   509 AVIASEDRYFIWHFVLPK----FNSVQA-------------GIH------VPGKSGDYVLEEQQR 550

  Fly   515 --GHSTQR--GISDPICALALSEKLLLVARESGAINEYSIANVALRNRHLMNAKVYKMAINCNST 575
              .:.|:|  |..|.||||.:.:...::|..||.|...|:.:..:.|.:.::..:..:.:||..|
Worm   551 TIEYGTKRLLGSKDEICALCIGDTFFMMALLSGGIYRVSLNDGVITNSYPVSPSINSIKLNCTFT 615

  Fly   576 RAAII---DHMGVMTLLDLDDNRETQLNFSRVERKDVWAVSWATDNPLLLALMEKTRMYIFRGND 637
            |.|:|   :.:....||...|..|.:|.::. :::|||...|..:|..:|||.:|.::.|..||.
Worm   616 RLAVIKLVEQVPFQFLLYEFDGDELKLIYTS-DKRDVWDYEWDQNNSNMLALKDKQKILICDGNS 679

  Fly   638 PEEPVSCSGYICTFEDLEITSVLLDDIISVGELQNFSHIIQLRVKSLRDTDDLLEHVGLEDAKQF 702
            ..|..|.:|.|..|::|.:|:|.::.|:...|....:.|:::.:|:.:|..:|:..:.||:|..:
Worm   680 ILEQSSVNGSILLFQNLVVTAVNIEKILLTPENPTKTCIVEVMIKAKQDVMNLVNAMKLEEAIDY 744

  Fly   703 IEDNPHPRLWRLLAESALKKLELETAENAFVRCAHYPGIKLVKRLRTIHSKELQRAEISAFYGEF 767
            .|.:||..||.::|..|:.|...:.||:|||:...|.|::|||:||.|.|.:|:.|||.|:....
Worm   745 AERSPHSELWSMIANYAVFKHAFDCAEHAFVKLGDYAGVQLVKKLRNIQSNDLRNAEIYAYRDTL 809

  Fly   768 EEAEKLYLDADRRDLAIELRMTLCDWFRVVQLYRMGGSGVSDQQMEIAWREIGHHFANLRSWESA 832
            |||:..:|.|||||||:|:...:.|:..|..|.|   :...|:....|:|.:......:..||.|
Worm   810 EEAKTAFLQADRRDLAVEMYKKVGDYASVYDLIR---NDDDDEGKCDAFRNMAETHYEMMEWEEA 871

  Fly   833 REYYEKSHYLEGYMEALYHLEQFDDLEKCVERLPEKSPLLPKLAEMLASVGMCSEAVQAHLRFGD 897
            .:.|.........::.|.....|.:||.....|.:.|..:..:.:...|.|||.:||:.:||...
Worm   872 AKAYSYCGDTANQIDCLIRGNLFGELEVLARTLSDDSEFMEVMGDAFTSRGMCDQAVECYLRRSL 936

  Fly   898 QKAAVATCVNLRQWGEAVELAQRFQLPQVQTLIAKHAAQLLQEGRLK--EAIEMQRNAGRHLDAA 960
            .:.|:..|..|.||.:|..:|....:..|:.|:.|.|.::..|...|  .|:.:...||||||||
Worm   937 PQKALHACKELNQWQKAQFIADANHMENVEGLLGKFAVEMRGESDEKSLSALALYMRAGRHLDAA 1001

  Fly   961 RLLSQMAEREQEKRAPLLRIKKLYVLAALLAEEHLKAVATTEIDYASGRNTLLDS------IALE 1019
            ::...:|:..:.|..|...:|:.|||.|:|.|.|.:.:  .|:......|.|.|:      ::.|
Worm  1002 KIAFDIAKDRKSKYVPYEELKQCYVLGAVLVENHRQTI--KELRKIDKHNFLEDALDDESGLSAE 1064

  Fly  1020 DAAAIERLWHCAEAYHFMLLAQRQLRFGIVHSAVVTAVRLRDYEDVLPPEHIYSLLALASCADRA 1084
            .:..:|..|..|||:|||::||:......:..|:.|::.|.|||:.|.|..::|::|||:.....
Worm  1065 QSRILENTWRGAEAFHFMIMAQQHFFENRIKDALQTSLILSDYEEFLDPAEVHSMIALAAANVNQ 1129

  Fly  1085 FGTCSKAFMKLEQQAHLPEATLQRYEELAAGIFAKYDPEDTTGDRVDCYSCGVPVPDSSPSCPEC 1149
            ||.||||.|:||......:|..:....|:..:|::..|.:....:|.|..|...:......|.||
Worm  1130 FGICSKAMMRLEAFEEFDDAEKEEMRNLSFRLFSENPPVNPNSAKVACSVCDAKIDPYDLQCSEC 1194

  Fly  1150 NARFPACISSGKPITQPTNNIWICTTCHHCAAPTEISRHRTCPLCHSL 1197
            ..:||.||:||:.|..  |..|:|..|.|.|...||.::..|||||.:
Worm  1195 QTKFPVCIASGRLILD--NIFWLCPRCKHRAHQHEIPKYNCCPLCHDM 1240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oseg4	NP_001261278.1	WD40	<7..217	CDD:225201	77/217 (35%)
		WD40	<18..242	CDD:295369	82/282 (29%)
		WD40 repeat	19..70	CDD:293791	18/51 (35%)
		WD40 repeat	76..115	CDD:293791	19/38 (50%)
		WD40 repeat	119..152	CDD:293791	16/32 (50%)
		WD40 repeat	161..202	CDD:293791	9/43 (21%)
		WD40 repeat	212..280	CDD:293791	23/123 (19%)
		WD40 repeat	290..333	CDD:293791	12/42 (29%)
		WD40	341..687	CDD:225201	96/363 (26%)
		TPR repeat	815..838	CDD:276809	6/22 (27%)
		TPR repeat	839..864	CDD:276809	4/24 (17%)
		TPR repeat	869..894	CDD:276809	7/24 (29%)
		YscO	877..980	CDD:284686	33/104 (32%)
		DUF3505	1163..>1188	CDD:288836	9/24 (38%)
ifta-1	NP_508940.4	WD40	<31..210	CDD:225201	73/183 (40%)
		WD40 repeat	38..87	CDD:293791	18/52 (35%)
		WD40 repeat	92..129	CDD:293791	19/36 (53%)
		WD40 repeat	137..173	CDD:293791	17/35 (49%)
		WD40 repeat	176..219	CDD:293791	10/42 (24%)
		ANAPC4_WD40	<334..392	CDD:372368	19/61 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167052
Domainoid	1	1.000	461	1.000	Domainoid score	I236
eggNOG	1	0.900	-	-		E1_KOG2041
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10814
Inparanoid	1	1.050	615	1.000	Inparanoid score	I489
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56447
OrthoDB	1	1.010	-	-		D91334at33208
OrthoFinder	1	1.000	-	-		FOG0006996
OrthoInspector	1	1.000	-	-		oto17584
orthoMCL	1	0.900	-	-		OOG6_103988
Panther	1	1.100	-	-	LDO	PTHR16517
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3735
SonicParanoid	1	1.000	-	-		X5088
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800