DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oseg4 and tub-2

DIOPT Version :9

Sequence 1:	NP_001261278.1	Gene:	Oseg4 / 38219	FlyBaseID:	FBgn0035264	Length:	1205	Species:	Drosophila melanogaster
Sequence 2:	NP_490913.2	Gene:	tub-2 / 171758	WormBaseID:	WBGene00022139	Length:	869	Species:	Caenorhabditis elegans

Alignment Length:	1029	Identity:	202/1029 - (19%)
Similarity:	353/1029 - (34%)	Gaps:	314/1029 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 IAWNKEE-----GYIAVAGTDGLLKVLKLD-QATPNGQSKGGLAAVSNLSMNQTLDGHKESVRVV 78
            ::|.:::     |.:.|....|.:.|...| :.||:..::          .|..|.||..::|:|
Worm    21 LSWIQQQDKPDHGLLGVGTETGSVGVTLTDFKPTPDDLTR----------YNFNLRGHHNAIRMV 75

  Fly    79 TWNDAQQKLTSSDTDGVIMVWMLYKGSWYEEMTNDRKKSTVASMSWTSDGSRICIVYEDGAIIVG 143
            |||.:|.||.|.|..|:|.||:.....|..|:.|||... |:.:||:..|....|.|:|..:::|
Worm    76 TWNKSQSKLASCDASGIIYVWVRNDDRWSVELVNDRGVK-VSDLSWSPCGGSALICYDDNFVLIG 139

  Fly   144 SVDGNRIFGKE--LKGTHLTGVQWSPDNRLILFALANGECHLYDNQGNFAMKLHIQCVNISGGSS 206
            |.:|.|::...  |......|| |:||:|.::...:.|...:..|.|          |||    :
Worm   140 SANGQRVWSNSFPLPAAVTCGV-WAPDSRQLVLGFSTGTIQVLSNAG----------VNI----T 189

  Fly   207 SRGHRIASICWFSGRVVQSRKRPV---LAICYENGRVQIMRNENDDAPAIFDTGMRNVDAKWNHD 268
            ||......:...:...::::.|.|   ||:.....::.::...:...|||:.:..:.:..:||.|
Worm   190 SRSFTEDKLTQMAFSPLRTKVREVEWTLAMLSSANKIYMISAYDQLHPAIYRSKFQVIRMEWNTD 254

  Fly   269 GTVLAICGTTLDAVSPTSQRDTNQVCFYSPLGKIYRTLKVPGTDITSLSWEGKSLRIAMAVDSFI 333
            ||:||:...            .|::.......::....::|..|      :.|:|
Worm   255 GTILALINA------------NNELVMIDTTCRVIHRERIPIAD------KEKTL---------- 291

  Fly   334 YFANIRPD-----YIWCYFEKTVVFLNSGSAT-------RESPMSVITF--WNTVSNQSFLKEVE 384
             ..|..|.     :.|.:....|:....|..|       ..|...::|:  |..:.
Worm   292 -IPNPPPTQKLTAFTWAHNGNVVIIAAGGCLTVGRILFGVPSLFEIVTYDLWKMMG--------- 346

  Fly   385 PTLCLASSSEHCVLGVECVSSNIKEIALSTLE-NRSNPADDRVYQLL------LCNSIGTTVDSK 442
                             |.|..:.::.:...| |.....|..|.:..      :|:.:.:.||::
Worm   347 -----------------CSSKKVDKLPIPLKEMNALRELDHHVIRCRIPRSQDMCSYVCSVVDAR 394

  Fly   443 -YTDIRPCFVGINSSYVAIASQEEILIWHYHTPKSASTLHNVKARKEKRF--------HIDDTPT 498
             |..|||         :|..|...:|.:.:    ....:..:..|:..||        :....||
Worm   395 CYCTIRP---------LARGSHTYVLCFEH----LGGLVPLLLGRQVNRFLPQFQIFMYQSKPPT 446

  Fly   499 GVEMAKDLMLSSSSGDGHSTQRGISDPICALALSEKLLLVARESGAINEYSIAN----------- 552
                       ||...|.|.|                   ..:..:|..||...
Worm   447 -----------SSPPSGSSAQ-------------------VEDVNSIFRYSTGRNSLWRRSKRQI 481

  Fly   553 VALRNRHL-----------MNAKVYKMAINCNSTRAAII-DHMGVM----TLLDLDDNRETQLNF 601
            .||.:||:           :.:.|:....|.:|...::: ..:|.:    ::|.|.. |:..::.
Worm   482 RALMSRHVRPTRPDTRLLQVTSNVWCTRFNISSLSPSLLPTFLGQVIYKTSVLHLQP-RQMTIDL 545

  Fly   602 SRVERKDVWAVSWATDNPLLLALMEKTRMYIFRGND-PEEPVSCSGYICTFEDLEITSVLLDDII 665
            :.::|||                          |.: ||..|..:.::.:..|..:||
Worm   546 AVLQRKD--------------------------GKELPEASVDGTTHMTSSPDQGLTS------- 577

  Fly   666 SVGELQNFSHIIQLRVKSLRDTDDLLEHVGLEDAKQFIEDNPHPRLWRLLAESALKKLELETAEN 730
               |.:.|...|.....|||         .:.::..|  ..|.|       .:|...:.|....:
Worm   578 ---EERQFFQKILAECLSLR---------AVINSSNF--GKPPP-------PAAASTISLPCQPS 621

  Fly   731 AFVR---CAHYPGIKLVKRLRTIHSKELQRAEISAFYGEFEEAEKL-YLDADRRDLAIELRMTL- 790
            ....   .||...|.    .||:.||....:..|:.....||.|.| ::|.|..:.|:.::..|
Worm   622 TSKEPDSSAHTTPIS----TRTVESKHDVTSMASSVSTWHEEIEALAFIDGDADEKAMLVQPALK 682

  Fly   791 CDWFRVVQLYRMGGSGVSDQQMEIAWREIGHHFANLRSWESAREYYEKSH-------------YL 842
            ..|..:.|        .|.:..|:    |..|...|   .|..|...|.|             .:
Worm   683 TGWAAMEQ--------ASKKDAEV----IRSHVDKL---ASIAEQLSKRHGDFNVKRDKASINKM 732

  Fly   843 EGYMEALYHLEQFDDLEKCV---ERLPEKSPLLPKLAEMLASVGMCSEAVQAHLRFGDQKAAVAT 904
            ...|:.|  |.:.:::|:.|   :...|...||..|.||..::|   |.|....|..:....:.|
Worm   733 RSQMKTL--LRRVNEIEQKVANGDVKTEVRQLLNTLNEMKKALG---EGVPKSGRSLNSTCKIET 792

  Fly   905 CVNLRQ-WGE-------------AVELAQRFQLPQVQTLIAKHAAQLLQEGRLK 944
            ..|... |.|             ..|.|:.||       |...:.|:||.||::
Worm   793 MTNKTPFWNEQNQVYQLDFGGRVTQESAKNFQ-------IELDSKQVLQFGRIE 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oseg4	NP_001261278.1	WD40	<7..217	CDD:225201	57/204 (28%)
		WD40	<18..242	CDD:295369	61/232 (26%)
		WD40 repeat	19..70	CDD:293791	10/55 (18%)
		WD40 repeat	76..115	CDD:293791	18/38 (47%)
		WD40 repeat	119..152	CDD:293791	11/32 (34%)
		WD40 repeat	161..202	CDD:293791	11/40 (28%)
		WD40 repeat	212..280	CDD:293791	14/70 (20%)
		WD40 repeat	290..333	CDD:293791	5/42 (12%)
		WD40	341..687	CDD:225201	63/403 (16%)
		TPR repeat	815..838	CDD:276809	5/22 (23%)
		TPR repeat	839..864	CDD:276809	6/40 (15%)
		TPR repeat	869..894	CDD:276809	8/24 (33%)
		YscO	877..980	CDD:284686	20/82 (24%)
		DUF3505	1163..>1188	CDD:288836
tub-2	NP_490913.2	WD40	65..>316	CDD:225201	71/295 (24%)
		WD40 repeat	73..110	CDD:293791	16/36 (44%)
		WD40 repeat	115..154	CDD:293791	11/38 (29%)
		WD40 repeat	158..203	CDD:293791	14/59 (24%)
		WD40 repeat	210..245	CDD:293791	7/34 (21%)
		WD40 repeat	246..272	CDD:293791	8/37 (22%)
		Cytochrom_B562	680..771	CDD:382596	23/107 (21%)
		Tub	<795..852	CDD:366500	13/52 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D91334at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910