DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oseg4 and wdr35

DIOPT Version :9

Sequence 1:	NP_001261278.1	Gene:	Oseg4 / 38219	FlyBaseID:	FBgn0035264	Length:	1205	Species:	Drosophila melanogaster
Sequence 2:	XP_002934527.2	Gene:	wdr35 / 100496375	XenbaseID:	XB-GENE-985175	Length:	1181	Species:	Xenopus tropicalis

Alignment Length:	1229	Identity:	604/1229 - (49%)
Similarity:	805/1229 - (65%)	Gaps:	80/1229 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFVYLSKKIAIPNNVKLNCIAWNKEEGYIAVAGTDGLLKVLKLDQATPNGQSKGGLAAVSNLSMN 65
            ||:|||||||||||:.|.||:|||::||||..|..||||||||:....:.:.| ||||.||||||
Frog     1 MFIYLSKKIAIPNNICLKCISWNKDQGYIACGGESGLLKVLKLEMQAEDAKLK-GLAAPSNLSMN 64

  Fly    66 QTLDGHKESVRVVTWNDAQQKLTSSDTDGVIMVWMLYKGSWYEEMTNDRKKSTVASMSWTSDGSR 130
            |||:||..||:|||||:..||||:||.:|:|:|||||||||||||.|:|.||.|.||||.:||.:
Frog    65 QTLEGHSGSVQVVTWNEHFQKLTTSDQNGLIIVWMLYKGSWYEEMINNRNKSVVRSMSWNADGQK 129

  Fly   131 ICIVYEDGAIIVGSVDGNRIFGKELKGTHLTGVQWSPDNRLILFALANGECHLYDNQGNFAMKLH 195
            |||||||||:||||||||||:||||||..|..|.||||::::||.:||||.|||||||||.:|:.
Frog   130 ICIVYEDGAVIVGSVDGNRIWGKELKGIQLCHVAWSPDSKILLFGMANGEIHLYDNQGNFIVKMV 194

  Fly   196 IQC-VNISGGSSSRGHRIASICWFSG-RVVQSRKRPVLAICYENGRVQIMRNENDDAPAIFDTGM 258
            :.| ||:||..|     ||.:.|:|| :.......|.||||::|||.||||:|||:.|.:.||||
Frog   195 LSCLVNVSGALS-----IAGMHWYSGNKGYVEPDCPCLAICFDNGRCQIMRHENDENPVLIDTGM 254

  Fly   259 RNVDAKWNHDGTVLAICGTTLDAVSPTSQRDTNQVCFYSPLGKIYRTLKVPGTDITSLSWEGKSL 323
            ..|..:|||.|:||||.|:...|   :..:|.|.|.||:|.|:..|||||||..|:::||||..|
Frog   255 NVVSIQWNHCGSVLAIAGSQRAA---SQDKDINIVQFYTPFGEHLRTLKVPGKQISAVSWEGGGL 316

  Fly   324 RIAMAVDSFIYFANIRPDYIWCYFEKTVVFLNSGSATR-ESPMSVITFWNTVSNQSFLKEVEPTL 387
            ||.:||||:||||||||||.|.|...|||:    :.|| :.|...:.||:|.:|:.::|.|:..:
Frog   317 RIGLAVDSYIYFANIRPDYKWGYCSNTVVY----ACTRPDRPEYCVVFWDTKNNEKYVKYVKSLM 377

  Fly   388 CLASSSEHCVLGVECVSSNIKEIALSTLENRSNPADDR-------VYQLLLCNSIGTTVDSKYTD 445
            .:.:..:.|:              |:|..:.|...|||       .|.|:|||||||.:||||.|
Frog   378 SVTTCGDFCI--------------LATKADESQQQDDRETDAIGATYVLVLCNSIGTPLDSKYID 428

  Fly   446 IRPCFVGINSSYVAIASQEEILIWHYHTPK--SASTLHNV-KARKEKR---FHIDDTPTGVEMAK 504
            |.|.||.:..::|..||:|...||.|...|  :|..::.| :.|||.|   |||||.|:|  ..:
Frog   429 IVPMFVTMTKTHVIAASKEAFYIWQYRVAKKLTAMEINQVSRTRKEGRERIFHIDDNPSG--SVE 491

  Fly   505 DLMLSSSSGDGHSTQRGISDPICALALSEKLLLVARESGAINEYSIANVALRNRHLMNAKVYKMA 569
            .||      |.........||||.:..|:|:|:|.||||.:..|::.:|:|..::::..:.|:|.
Frog   492 GLM------DYAKAVEATRDPICCITASDKVLIVGRESGTLRRYTLPSVSLVQQYMLGTRAYQMR 550

  Fly   570 INCNSTRAAIIDHMGVMTLLDLD----DNRETQLNFS--RVERKDVWAVSWATDNPLLLALMEKT 628
            :|||::|.||||..||:|..||:    ||...|:...  ::||||||.:.||:|||.|.|:||||
Frog   551 LNCNASRLAIIDISGVLTFFDLEARYTDNTGQQMTGEQLKLERKDVWDMKWASDNPDLFAMMEKT 615

  Fly   629 RMYIFRGNDPEEPVSCSGYICTFEDLEITSVLLDDIISVGELQNFSHIIQLRVKSLRDTDDLLEH 693
            |||:||..|||||:..|||||.||||||.|||||::|...|..|..:|:...::||||:..|:|.
Frog   616 RMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDELIKDPEHPNKDYILNFEIRSLRDSRALIEK 680

  Fly   694 VGLEDAKQFIEDNPHPRLWRLLAESALKKLELETAENAFVRCAHYPGIKLVKRLRTIHSKELQRA 758
            ||:|||.|||||||||||||||||:||:||:|.|||.|||||..|.||:.||||..:.|:.:::|
Frog   681 VGIEDASQFIEDNPHPRLWRLLAEAALEKLDLPTAEQAFVRCKDYQGIEFVKRLGNLQSESMKQA 745

  Fly   759 EISAFYGEFEEAEKLYLDADRRDLAIELRMTLCDWFRVVQLYRMGGSGVSDQQMEIAWREIGHHF 823
            ||:|::|.|.||||:|||.|||||||.||:.|.|||||:||.:.|.....|..:|.|:..||.:|
Frog   746 EIAAYFGRFVEAEKMYLDMDRRDLAIGLRIKLGDWFRVLQLLKHGSGDSDDALLEQAYNAIGDYF 810

  Fly   824 ANLRSWESAREYYEKSHYLEGYMEALYHLEQFDDLEKCVERLPEKSPLLPKLAEMLASVGMCSEA 888
            |:.:.|.:|.:||.:....|...|..|.||.::.||.....|||...|||::|.|..:||||.:|
Frog   811 ADRQKWVNAVQYYVQGRNQERLAECYYMLEDYNGLEVLANSLPENHKLLPEIARMFVTVGMCEQA 875

  Fly   889 VQAHLRFGDQKAAVATCVNLRQWGEAVELAQRFQLPQVQTLIAKHAAQLLQEGRLKEAIEMQRNA 953
            |.|.|:....||||..||:|.||.:|||||:...:.::.:|:||:|:.||::.:..:|||:.|.|
Frog   876 VAAFLKCNLPKAAVDACVHLNQWNKAVELAKNHNMKEIGSLLAKYASHLLEKNKTLDAIELYRKA 940

  Fly   954 GRHLDAARLLSQMAEREQEKRAPLLRIKKLYVLAALLAEEHLKAVATTEIDYASGRNT------- 1011
            ...|:||:|:.::||.|.:||:..||:||||||||||.|.:.:.:..|:.....|:.|
Frog   941 NHFLEAAKLMFKIAEDEAKKRSKPLRVKKLYVLAALLVEHYHEHMKNTQKGKLKGKRTEATSALA 1005

  Fly  1012 --LLDSIALEDAAAIERLWHCAEAYHFMLLAQRQLRFGIVHSAVVTAVRLRDYEDVLPPEHIYSL 1074
              |.:...|.|...|:..|..||||||.|||||||..|.:.:|:.||:.||||||::|...||||
Frog  1006 SLLEEDSMLSDNRIIDHAWRGAEAYHFFLLAQRQLYEGYLDAAMRTALHLRDYEDIIPAVEIYSL 1070

  Fly  1075 LALASCADRAFGTCSKAFMKLEQQAHLPEATLQRYEELAAGIFAKYDPEDTTGDRVDCYSCGVPV 1139
            |||.:||:||||||||||:|||...:|.....|:||:||..||.|:.|:||....::.:
Frog  1071 LALCACANRAFGTCSKAFIKLESLENLTAEQKQQYEDLALEIFTKHSPKDTRKPDLENF------ 1129

  Fly  1140 PDSSPSCPECNARFPACISSGKPITQPTNNIWICTTCHHCAAPTEISRHRTCPLCHSLI 1198
            |:..      ..:.|.||:||:.||:  ...|:|..|.||....||:.:..||||||.|
Frog  1130 PEGG------EGKLPTCIASGRVITE--YQFWMCNVCKHCVLDREITNYNFCPLCHSSI 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oseg4	NP_001261278.1	WD40	<7..217	CDD:225201	137/210 (65%)
		WD40	<18..242	CDD:295369	139/225 (62%)
		WD40 repeat	19..70	CDD:293791	32/50 (64%)
		WD40 repeat	76..115	CDD:293791	27/38 (71%)
		WD40 repeat	119..152	CDD:293791	26/32 (81%)
		WD40 repeat	161..202	CDD:293791	24/41 (59%)
		WD40 repeat	212..280	CDD:293791	35/68 (51%)
		WD40 repeat	290..333	CDD:293791	25/42 (60%)
		WD40	341..687	CDD:225201	148/365 (41%)
		TPR repeat	815..838	CDD:276809	9/22 (41%)
		TPR repeat	839..864	CDD:276809	7/24 (29%)
		TPR repeat	869..894	CDD:276809	12/24 (50%)
		YscO	877..980	CDD:284686	44/102 (43%)
		DUF3505	1163..>1188	CDD:288836	9/24 (38%)
wdr35	XP_002934527.2	WD40 repeat	18..69	CDD:293791	32/51 (63%)
		WD40	<19..215	CDD:225201	129/201 (64%)
		WD40 repeat	74..111	CDD:293791	27/36 (75%)
		WD40 repeat	119..157	CDD:293791	30/37 (81%)
		WD40 repeat	159..196	CDD:293791	22/36 (61%)
		WD40 repeat	253..300	CDD:293791	22/49 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	838	1.000	Domainoid score	I64
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10814
Inparanoid	1	1.050	1129	1.000	Inparanoid score	I225
OMA	1	1.010	-	-		QHG56447
OrthoDB	1	1.010	-	-		D91334at33208
OrthoFinder	1	1.000	-	-		FOG0006996
OrthoInspector	1	1.000	-	-		oto103290
Panther	1	1.100	-	-	LDO	PTHR16517
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5088
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080