Protein Alignment drpr and SCARF2

DIOPT Version :10

• Sequence 1: NP_001261276.1
• Gene: drpr / 38218
• FlyBaseID: FBgn0027594
• Length: 1042
• Species: Drosophila melanogaster
• Sequence 2: XP_047297541.1
• Gene: SCARF2 / 91179
• HGNCID: 19869
• Length: 904
• Species: Homo sapiens
• Alignment Length: 589
• Identity: 178/589 - (30%)
• Similarity: 230/589 - (39%)
• Gaps: 180/589 - (30%)

  Fly    96 GECVPHCSEPCQHGRCISPEKCKCDHGYGGPACDINCPP------------GW--YGRNCSMQ-C 145
            |.|.....||            ..|.|: |....:.|||            ||  .|..|.:. |
Human    67 GGCAEAAEEP------------GADGGW-GRGIGLRCPPSARSSQVPTCCAGWRQQGDECGIAVC 118

  Fly   146 D----CLNNAVC-EPFSGDCECAKGYTGARCADICPEGFFGANCSEKCRCENGGKCHHVSGECQC 205
            :    |..|.|| .|  |:|.|..||.||.|...||..|:|.:|.|.|.|...|:|..|:|:|.|
Human   119 EGNSTCSENEVCVRP--GECRCRHGYFGANCDTKCPRQFWGPDCKELCSCHPHGQCEDVTGQCTC 181

  Fly   206 APGFTGPLCDMRCPDGKHGAQCQQDCPCQNDGKCQPETGACMCNPGWTGDVCANKCPVGSYGPGC 270
            ..             .:.||:|:..|.||: |.|.|.:|||.|.|||
Human   182 HA-------------RRWGARCEHACQCQH-GTCHPRSGACRCEPGW------------------ 214

  Fly   271 QESCECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCDCANDAMCDRANGTCICN 335
                                                  :|..|:..|.|:..:.||...|.|:|:
Human   215 --------------------------------------WGAQCASACYCSATSRCDPQTGACLCH 241

  Fly   336 PGWTGAKCAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSAQCTRPCTFLRYGP 400
            .||              :|..||..|.|   ::..|..::|.|||          |..||   |.
Human   242 AGW--------------WGRSCNNQCAC---NSSPCEQQSGRCQC----------RERTF---GA 276

  Fly   401 NCELTCNCKNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQDCALRC-DCQNGAKCEPETGQC 464
            .|:..|.|..| :|.||:|||.|.||:||..|.|.|..|.:|..|..|| .|:....|....|:|
Human   277 RCDRYCQCFRG-RCHPVDGTCACEPGYRGKYCREPCPAGFYGLGCRRRCGQCKGQQPCTVAEGRC 340

  Fly   465 L-CTAGWKNIKCDRPCDLNHFGQDCAKVC-DCHNNAACNPQNGSCT-CAAGWTGERCERKCDTGK 526
            | |..||...|||:||....:|:.|:..| .|.:..|||...|.|| |.|||.|:|||.||..|.
Human   341 LTCEPGWNGTKCDQPCATGFYGEGCSHRCPPCRDGHACNHVTGKCTRCNAGWIGDRCETKCSNGT 405

  Fly   527 FGHDCAQKC-QCDFNNSLACDATNGRCVCKQDWGGVHCETNCRSGYYGENCDKVCRCLNNSSCDP 590
            :|.|||..| .|   .|..||..:|||:|.....|.||...|..|.:|.:|.:.|.| :..:|||
Human   406 YGEDCAFVCADC---GSGHCDFQSGRCLCSPGVHGPHCNVTCPPGLHGADCAQACSC-HEDTCDP 466

  Fly   591 DSGNC---------ICSAG------------WTGADCAEPCPPGFYGMECKERCP---EILHGNK 631
            .:|.|         :..||            ..|..||           |:.:.|   |:..|.|
Human   467 VTGACHLETNQRKGVMGAGALLVLLVCLLLSLLGCCCA-----------CRGKDPTRRELSLGRK 520

  Fly   632 SCDH 635
            ...|
Human   521 KAPH 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	26..92	CDD:462204
		EGF_CA	274..319	CDD:473889	3/44 (7%)
		gliding_CglD	<451..579	CDD:468178	54/131 (41%)
		DSL	567..609	CDD:473190	16/62 (26%)
SCARF2	XP_047297541.1	PHA03247	<567..904	CDD:223021