DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drpr and SCARF1

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_003684.2	Gene:	SCARF1 / 8578	HGNCID:	16820	Length:	830	Species:	Homo sapiens

Alignment Length:	514	Identity:	165/514 - (32%)
Similarity:	220/514 - (42%)	Gaps:	136/514 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 KCHHV------SGECQCAPGF-------TGPLCDMRCPDGKHGAQCQQDCPCQNDGKCQPETGAC 246
            |..||      |.|.||..|:       |.|:|:  .||.           ||.|..| .:.|.|
Human    25 KGQHVCVASSPSAELQCCAGWRQKDQECTIPICE--GPDA-----------CQKDEVC-VKPGLC 75

  Fly   247 MCNPGWTGDVCANKCPVGSYGPGCQESCECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGF 311
            .|.||:.|..|:::||...:||.|:|||.|:....|...||.|             :||.:.:|.
Human    76 RCKPGFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGAC-------------QCQADRWGA 127

  Fly   312 NCSMTCDCANDAMCDRANGTCICNPGWTGAKCAERICEANKYGLDCNRTCECDMEHTDLCHPETG 376
            .|...|.|.....||.|.|.|.|.|||              :...|.|.|:|:.. ...|...||
Human   128 RCEFPCACGPHGRCDPATGVCHCEPGW--------------WSSTCRRPCQCNTA-AARCEQATG 177

  Fly   377 NCQCSIGWSSAQCTRPCTFLRYGPNCELTCNCKNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTF 441
            .|.|..||             :|..|...||| :|:.|...:|.|.|.|||.||.|::.||
Human   178 ACVCKPGW-------------WGRRCSFRCNC-HGSPCEQDSGRCACRPGWWGPECQQQCE---- 224

  Fly   442 GQDCALRCDCQNGAKCEPETGQCLCTAGWKNIKCDRPCDLNHFGQDCAKVCD-CHNNAACNPQNG 505
                     |..| :|...:|:|.|..|::..:|:.||.....|..||..|. |.:|..|:|..|
Human   225 ---------CVRG-RCSAASGECTCPPGFRGARCELPCPAGSHGVQCAHSCGRCKHNEPCSPDTG 279

  Fly   506 SC-TCAAGWTGERCERKCDTGKFGHDCAQKCQCDFNNSLACDATNGRCVCKQDWGGVHCETNCRS 569
            || :|..||.|.:|::.|..|.||..|.|:|.                         ||.
Human   280 SCESCEPGWNGTQCQQPCLPGTFGESCEQQCP-------------------------HCR----- 314

  Fly   570 GYYGENCDKVCRCLNNSSCDPDSGNC-ICSAGWTGADCAEPCPPGFYGMECKERCPEILHGNKSC 633
              :||            :|:||:|:| .|..||.|..|.:|||.|.:|.:|...||..:.|  ||
Human   315 --HGE------------ACEPDTGHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCVQG--SC 363

  Fly   634 DHITGEILCRTGYIGLTCEHPCPAGLYGPGCKLKCNCEHGGECNHVTGQCQCLPGWTGS 692
            |.:||:.:|..||.|.:|...||||.:|..|.:.|.|.. |.|:.|:|.||  || :||
Human   364 DTVTGDCVCSAGYWGPSCNASCPAGFHGNNCSVPCECPE-GLCHPVSGSCQ--PG-SGS 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395	11/44 (25%)
		DSL	<479..518	CDD:302925	16/40 (40%)
		DSL	<567..606	CDD:302925	11/39 (28%)
SCARF1	NP_003684.2	CSRNP_N	<100..135	CDD:292638	13/47 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..539
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..688
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..830
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810