DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drpr and MEGF11

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_001371957.1	Gene:	MEGF11 / 84465	HGNCID:	29635	Length:	1140	Species:	Homo sapiens

Alignment Length:	1130	Identity:	379/1130 - (33%)
Similarity:	537/1130 - (47%)	Gaps:	150/1130 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VILIACLAQLVLAQADLK-DLDGPNICKRRELYNVDVVYTELQSFQERGSTWCVTFPP--RCSTY 65
            |:.:..|......||.|. :.:.||:|...|.|.|.|..:....|.:...|.|.....  :|:.:
Human     2 VLSLTGLIAFSFLQATLALNPEDPNVCSHWESYAVTVQESYAHPFDQIYYTRCTDILNWFKCTRH 66

  Fly    66 RIKHRVVNK--TKTIAKNRIVRDCCDGYIASAGECVPHCSEPCQHGRCISPEKCKCDHGYGGPAC 128
            ||.::...:  .:|:.:.|  ..||.||..|...|:|.|:|.|.||||:||:.|.|:.|:|||.|
Human    67 RISYKTAYRRGLRTMYRRR--SQCCPGYYESGDFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDC 129

  Fly   129 DINCPPGWYGRNCSMQCDCLNNAVCEPFSGDCECAKGYTGARCADICPEGFFGANCSEKCRCENG 193
            ...|....:|.:||.:|.|.|.|:|.|.:|.|.||.|:.|.||.::|..|..|..|...|:|.:|
Human   130 SSGCDSDHWGPHCSNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHG 194

  Fly   194 GKCHHVSGECQCAPGFTGPLCDMRCPDGKHGAQCQQDCPCQNDGKCQPETGACMCNPGWTGDVCA 258
            ..|...:|||.||||:||..|:..||.|.|||.|:..|||||.|.|...||.|.|.|||||.|||
Human   195 ASCDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCA 259

  Fly   259 NKCPVGSYGPGCQESCECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCDCANDA 323
            ..||.|::|..|.:.|.|:.|..|.|:||||.|..||.|:||.:||...::||.||..|||.|..
Human   260 QPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGG 324

  Fly   324 MCDRANGTCICNPGWTGAKCAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSAQ 388
            .|....|.|.|.||:.|.:|.||:|....:|..|...|.||.::|..|||.||.|.|..|||...
Human   325 QCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHH 389

  Fly   389 CTRPCTFLRYGPNCELTCNCKNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQN 453
            |...|....||..|:|.|.|:|||.|..:.|.|.||||:.|..|..||..||:|.:|:..|.|.|
Human   390 CNESCPVGYYGDGCQLPCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNN 454

  Fly   454 GAKCEPETGQCLCTAGWKNIKCDRPCDLNHFGQDCAKVCDCHNNAACNPQNGSCTCAAGWTGERC 518
            |..|.|..|.|.|..||:.:.|..||....:|.:|.:.|.|.|.|||:|.:|||:|..||.|:.|
Human   455 GGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTC 519

  Fly   519 ERKCDTGKFGHDCAQKCQCDFNNSLACDATNGRCVCKQDWGGVHCETNCRSGYYGENCDKVCRCL 583
            |..|..|.||.:|::.|.|  :::..||...|.|.|...|.|:.|::.|..|.:|.||...|.|.
Human   520 ELPCPDGTFGLNCSEHCDC--SHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCE 582

  Fly   584 NNSSCDPDSGNCICSAGWTGADCAEPCPPGFYGMECKERCPEILHGNKSCDHITGEILCRTGYIG 648
            |..||.|:.|:|.|:.|:.|..|...|||||||..|.:.||..:|.::.|.||:|...|..|:.|
Human   583 NGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICECLPGFSG 647

  Fly   649 LTCEHPCPAGLYGPGCKLKCNCEHGGECNHVTGQCQCLPGWTGSNCNESCPTDTYGQGCAQRCRC 713
            ..|...|..|.:|..|...|:|.:.|.|:.:.|.|||.|||.|.:|:::||...:|..|...|.|
Human   648 ALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFWGPACFHACSC 712

  Fly   714 VHHKVCRKADGMCICETGWSGTRCDEVCPEGFYGEHCMNTCACPSANFQCHAAHGCVCRSGYTGD 778
            .:...|...||.|.|..||:|..|.:.||..|:|:.|...|.|.:.....|.:..|.||:|:||.
Human   713 HNGASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCDHISGKCTCRTGFTGQ 777

  Fly   779 NCDELIA-------SQRIADQSENSS--------------------------------------- 797
            :|::..|       .|::.:...||:
Human   778 HCEQRCAPGTFGYGCQQLCECMNNSTCDHVTGTCYCSPGFKGIRCDQAALMMEELNPYTKISPAL 842

  Fly   798 ---RASV-ALTLVLMTLFACII-FAVFIYYRRRVSNLKTEIA-HVHYTHDTNPPSWPPNHNFDNP 856
               |.|| |:|.:::.||..:: ..:|.::|||......::| .|.||                |
Human   843 GAERHSVGAVTGIMLLLFLIVVLLGLFAWHRRRQKEKGRDLAPRVSYT----------------P 891

  Fly   857 VYGMQAETRLLPNNMRSKMNNFDQRSTMSTDY--GDDCNASGRVGSYSINYNHDL------LTKN 913
            ...|                       .||||  .|...:|.....:|.:..|.|      .::.
Human   892 AMRM-----------------------TSTDYSLSDLSQSSSHAHCFSNSSYHALACGGPATSQA 933

  Fly   914 LNADRTNPI-VYNESLKEEHV----YDEIKHKEGYKDPVKIYSKILFPEDEYDHLDY-SRPSTSQ 972
            ...||.:|. :.|:||..:..    |..:...:.:.....:.::.. |||.|..|.: |||:
Human   934 STLDRNSPTKLSNKSLDRDTAGWTPYSYVNVLDSHFQISALEARYP-PEDFYIELRHLSRPA--- 994

  Fly   973 KPHY-------HRMNDAML------------------NINQDEEKPSNVKNMTVLLNKPLPPTE- 1011
            :||.       .|.|..::                  ::|..|...:.:|:..:|..| ||.:.
Human   995 EPHSPGACGMDRRQNTYIMDKGFKDYMKESVCSSSTCSLNSSENPYATIKDPPILTCK-LPESSY 1058

  Fly  1012 ---PEPQHECFDNTNTNLDNVSTAS 1033
               ..|.|  ..:..|::.::||::
Human  1059 VEMKSPVH--MGSPYTDVPSLSTSN 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877	17/68 (25%)
		EGF_CA	274..319	CDD:304395	22/44 (50%)
		DSL	<479..518	CDD:302925	17/38 (45%)
		DSL	<567..606	CDD:302925	16/38 (42%)
MEGF11	NP_001371957.1	EMI	26..93	CDD:400092	17/68 (25%)
		EGF_CA	275..320	CDD:419698	22/44 (50%)
		EGF_CA	362..409	CDD:419698	21/46 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7834
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13031
Inparanoid	1	1.050	792	1.000	Inparanoid score	I516
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47996
OrthoDB	1	1.010	-	-		D34806at33208
OrthoFinder	1	1.000	-	-		FOG0001631
OrthoInspector	1	1.000	-	-		otm40878
orthoMCL	1	0.900	-	-		OOG6_102891
Panther	1	1.100	-	-	O	PTHR24035
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5768
SonicParanoid	1	1.000	-	-		X1195
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.870