Protein Alignment drpr and Egfem1

DIOPT Version :10

• Sequence 1: NP_001261276.1
• Gene: drpr / 38218
• FlyBaseID: FBgn0027594
• Length: 1042
• Species: Drosophila melanogaster
• Sequence 2: XP_006535622.1
• Gene: Egfem1 / 75740
• MGIID: 1922990
• Length: 658
• Species: Mus musculus
• Alignment Length: 689
• Identity: 170/689 - (24%)
• Similarity: 228/689 - (33%)
• Gaps: 236/689 - (34%)

  Fly    23 LDGPNICKRRELYNVDVVYTELQSFQE---------RGSTWCVTFPPRCSTYRI-KHRVVNKTKT 77
            |..||:|:..:|..|.:.....|:|.:         .|..|||.:..|...|.| :|....:.:|
Mouse    67 LSRPNVCREEQLTLVRLSRPCAQAFIDTIQFWKQGCSGPRWCVGYERRIRYYIIYRHVYATEHQT 131

  Fly    78 IAKNRIVRDCCDGYIASAGE--CVPHCSEPCQH--GRCIS---PEKCKCDHGYGGPAC--DINCP 133
            :.:      ||.|:|....|  |....|....|  ||..|   ..:|.|..|:.||.|  |||
Mouse   132 VFR------CCPGWIQWDDEPGCFSSLSSLGTHFSGRECSYQDTRQCLCSQGFHGPHCQYDIN-- 188

  Fly   134 PGWYGRNCSMQCDCLNNAVCEPFSGDCECAKGYTGARCADICPEGFFGANC----SEKCRCENGG 194
                                       |||....|  |.|.|        |    |..|||:.|.
Mouse   189 ---------------------------ECAVDNGG--CRDRC--------CNTIGSYYCRCQAGQ 216

  Fly   195 KCHHVSGECQCAPGFTGPLCDMRCPDGKHGAQCQQDCPCQNDGKCQPE------TGACMCNPGWT 253
            |...                     ||: |.:...:|...|.| ||..      |..|.|:.|:.
Mouse   217 KLEE---------------------DGR-GCEDVDECAVVNGG-CQQRCINTLGTFHCECDTGYR 258

  Fly   254 GDVCANKCPVG--------SYGPGCQESCECYKGAPCHHITGQCECPPGYR----GERCFD--EC 304
            .......|.:.        :...||...|:...|      ..:|.|..||:    .:.|.|  ||
Mouse   259 RHADERTCIISFLSETDPCAGANGCAHLCQTENG------MARCACHAGYQLSEDKKACEDINEC 317

  Fly   305 QLNTYGFNCSMTCDCANDAMCDRANGTCICNPGW-TGA---KCAE------RICEANKYGLDCNR 359
                    ......||:..:..:.:.||.|:||: .||   .|..      .|||.|..|  |:.
Mouse   318 --------AEELAPCAHHCVNSKGSFTCTCHPGFELGADRKHCYRIELEIVNICEKNNGG--CSH 372

  Fly   360 TCE-------CDMEHTDLCHPETGNC----QCSIGWSSAQCTRPCTFLRYGPNCELTCNCKNGAK 413
            .||       |...|......:...|    :|..|  .|.|.:.|  :.|....|  |:|:.|.:
Mouse   373 HCEPAIGGAHCSCNHGHQLDTDGKTCIDFDECESG--EACCAQLC--INYLGGYE--CSCEEGFQ 431

  Fly   414 CSPVNGTC----------------LCAPG-----------WRGPTCEES---------------- 435
            .|.....|                |..||           :..|:...|
Mouse   432 ISSDGCGCDALDEQLEEEEEEIDILRFPGRLAQNPPQPFPYLDPSLTASYEDEDNDDADSEAEGE 496

  Fly   436 -----------CEPGTFGQDCALRC-DCQNGAKCEPETGQCLCTAGWKNIKCDRP---------- 478
                       |..||||.||:|.| ||.||.:|:.....|||.|.|..:.|:..
Mouse   497 VQGLTALYRVVCLDGTFGLDCSLSCEDCMNGGRCQEGKSGCLCPAEWTGLICNESSVLRTGEDQQ 561

  Fly   479 ----CDLNHFGQDCAKVCDCHNNAACNPQNGSCTCAAGWTGERCERKCDTGKFGHDCAQKCQCDF 539
                |....||::|.:.|.|.||..|:...|:|.|..|..|..|...|..|.:|..|:.:|||..
Mouse   562 APAGCLKGFFGKNCKRKCHCANNVHCHRVYGACMCDLGRYGRFCHLSCPRGAYGASCSLECQCVE 626

  Fly   540 NNSLACDATNGRCVCKQDWGGVHCETNCRSGYYGENCDK 578
            .|:|.|.|.||.|.||             |||.|..|.:
Mouse   627 ENTLECSAKNGSCTCK-------------SGYQGNRCQE 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	26..92	CDD:462204	19/75 (25%)
		EGF_CA	274..319	CDD:473889	10/50 (20%)
		gliding_CglD	<451..579	CDD:468178	46/142 (32%)
		DSL	567..609	CDD:473190	5/12 (42%)
Egfem1	XP_006535622.1	FXa_inhibition	190..225	CDD:464251	15/66 (23%)
		FXa_inhibition	231..266	CDD:464251	9/35 (26%)
		vWFA	<268..310	CDD:469594	8/47 (17%)
		vWFA	<308..350	CDD:469594	13/49 (27%)
		FXa_inhibition	363..398	CDD:464251	9/36 (25%)
		vWFA	<395..436	CDD:469594	12/46 (26%)