DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drpr and Pear1

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_001027585.1	Gene:	Pear1 / 73182	MGIID:	1920432	Length:	1034	Species:	Mus musculus

Alignment Length:	1118	Identity:	366/1118 - (32%)
Similarity:	493/1118 - (44%)	Gaps:	172/1118 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLPVILIACLAQLVLAQADLKDLDGPNICKRRELYNVDVVYTELQSFQERGSTWC---VTFPPRC 62
            :.|::|:|    |.|......:.:.||:|...|.:......:.|:.|....:..|   ...|..|
Mouse     3 LCPLLLLA----LGLRLTGTLNSNDPNVCTFWESFTTTTKESHLRPFSLLPAESCHRPWEDPHTC 63

  Fly    63 STYRIKHRVVNKTKTIAKNRIVRDCCDGYIASAGECVPHCSEPCQHGRCISPEKCKCDHGYGGPA 127
            :...:.:|.|.:......:|....||.||..|.|.|||.|::.|.||||::|.:|:|..|:.|..
Mouse    64 AQPTVVYRTVYRQVVKMDSRPRLQCCRGYYESRGACVPLCAQECVHGRCVAPNQCQCAPGWRGGD 128

  Fly   128 CDINCPPGWYGRNCSMQCDCLNNAVCEPFSGDCECAKGYTGARCADICPEGFFGANCSEKCRCEN 192
            |...|.||.:|..|...|.|.||:.|:|.||.|.|..|.....|...||.|.:|..|...|:| .
Mouse   129 CSSECAPGMWGPQCDKFCHCGNNSSCDPKSGTCFCPSGLQPPNCLQPCPAGHYGPACQFDCQC-Y 192

  Fly   193 GGKCHHVSGECQCAPGFTGPLCDMRCPDGKHGAQCQQDCPCQNDGKCQPETGACMCNPGWTGDVC 257
            |..|....|.|.|.||..||.|::.|..|..|..|.:..||||.|..|...|:|.|.|||.|.:|
Mouse   193 GASCDPQDGACFCPPGRAGPSCNVPCSQGTDGFFCPRTYPCQNGGVPQGSQGSCSCPPGWMGVIC 257

  Fly   258 ANKCPVGSYGPGCQESCECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCDCAND 322
            :..||.|.:||.|.:.|.|:.|..|...||||.|.|||.|:||.:||.:..:|.:|:.|||||..
Mouse   258 SLPCPEGFHGPNCTQECRCHNGGLCDRFTGQCHCAPGYIGDRCQEECPVGRFGQDCAETCDCAPG 322

  Fly   323 AMCDRANGTCICNPGWTGAKCAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSA 387
            |.|..|||.|:|..|:||.:|.||:|...:|||.|...|.||.||:..|||..|.|.|..||:..
Mouse   323 ARCFPANGACLCEHGFTGDRCTERLCPDGRYGLSCQEPCTCDPEHSLSCHPMHGECSCQPGWAGL 387

  Fly   388 QCTRPCTFLRYGPNCELTCNCKNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQ 452
            .|...|....:||.|:..|.|.:|..|...:|.|.||||:.||.|...|.|.|:|.:|:.||.|:
Mouse   388 HCNESCPQDTHGPGCQEHCLCLHGGLCLADSGLCRCAPGYTGPHCANLCPPDTYGINCSSRCSCE 452

  Fly   453 NGAKCEPETGQCLCTAGWKNIKCDRPCDLNHFGQDCAKVCDCHNNAACNPQNGSCTCAAGWTGER 517
            |...|.|..|.|:|..||:...|..||.|..:|.:|...|.|.::..|:||.|:|||..||.|..
Mouse   453 NAIACSPIDGTCICKEGWQRGNCSVPCPLGTWGFNCNASCQCAHDGVCSPQTGACTCTPGWHGAH 517

  Fly   518 CERKCDTGKFGHDCAQKCQCDFNNSLACDATNGRCVCKQDWGGVHCETNCRSGYYGENCDKVCRC 582
            |:..|..|:||..||..|.||  :|..||..:|:|.|:..|.|..|...|..|::|.||...|.|
Mouse   518 CQLPCPKGQFGEGCASVCDCD--HSDGCDPVHGQCRCQAGWMGTRCHLPCPEGFWGANCSNTCTC 580

  Fly   583 LNNSSCDPDSGNCICSAGWTGADCAEPCPPGFYGMECKERCPEILHGNKSCDHITGEILCRTGYI 647
            .|..:|..::|||:|:.|:.|..|..|||||.||..|                    :.|
Mouse   581 KNGGTCVSENGNCVCAPGFRGPSCQRPCPPGRYGKRC--------------------VQC----- 620

  Fly   648 GLTCEHPCPAGLYGPGCKLKCNCEHGGECNHVTGQCQCLPGWTGSNCNESCPTDTYGQGCAQRCR 712
                               |||..| ..|:...|.|.||.||||.:|:|:||...:|..|:|.|:
Mouse   621 -------------------KCNNNH-SSCHPSDGTCSCLAGWTGPDCSEACPPGHWGLKCSQLCQ 665

  Fly   713 CVHHKVCRKADGMCICETGWSGTRCDEVCPEGFYGEHCMNTCACPSANFQCHAAHG-CVCRSGYT 776
            |.|...|...||.|||..||:|..|.|.||...:|.:|...|.|.... .||...| |||..|::
Mouse   666 CHHGGTCHPQDGSCICTPGWTGPNCLEGCPPRMFGVNCSQLCQCDLGE-MCHPETGACVCPPGHS 729

  Fly   777 GDNC----DELIASQRIADQSENSSRASVALTLVLMTLFACIIFAVFIYYRRRVSNLKTEIAHVH 837
            |.:|    .|.......:..:.||..|.:.:. ||.||...:| |:||.||:.....:.|...|.
Mouse   730 GADCKMGSQESFTIMPTSPVTHNSLGAVIGIA-VLGTLVVALI-ALFIGYRQWQKGKEHEHLAVA 792

  Fly   838 YT------HDTNPPSWPP--NHNFDNPVY-----------------------GMQAETRLLPNNM 871
            |:      .|...|...|  :|.:.||.|                       ..||..|  |:..
Mouse   793 YSTGRLDGSDYVMPDVSPSYSHYYSNPSYHTLSQCSPNPPPPNKVPGSQLFVSSQAPER--PSRA 855

  Fly   872 RSKMNNFDQRSTMSTDY-----GDDCNASGRVGSYSINYNHDLLTKNLNADRTNPIVYNE----- 926
            ..:.|:.    |:..|:     ..:..||....|||.:|:|          |..|..:..
Mouse   856 HGRENHV----TLPADWKHRREPHERGASHLDRSYSCSYSH----------RNGPGPFCHKGPIS 906

  Fly   927 ---------SLKEEHVYDEIK---------HKEGY---KDPVKIYSKILFPEDEYDHLDYSRPST 970
                     ||..|:.|..|:         .:.||   |.|                     ||.
Mouse   907 EEGLGASVMSLSSENPYATIRDLPSLPGEPRESGYVEMKGP---------------------PSV 950

  Fly   971 S---QKPHYHRMNDAMLNINQDE---EKPSNVKNMTVLLNK--PLPPTEPEPQHECFDNTNT--N 1025
            |   |..|........|...:|.   |:||.:.:....|..  ||||..|...::...|::.  :
Mouse   951 SPPRQSLHLRDRQQRQLQPQRDSGTYEQPSPLSHNEESLGSTPPLPPGLPPGHYDSPKNSHIPGH 1015

  Fly  1026 LDNVSTASPSSSP 1038
            .|......|.|.|
Mouse  1016 YDLPPVRHPPSPP 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877	14/67 (21%)
		EGF_CA	274..319	CDD:304395	21/44 (48%)
		DSL	<479..518	CDD:302925	16/38 (42%)
		DSL	<567..606	CDD:302925	15/38 (39%)
Pear1	NP_001027585.1	EMI	25..93	CDD:284877	14/67 (21%)
		EGF_CA	535..580	CDD:304395	18/46 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	823..883		9/65 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	925..1034		26/125 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	119	1.000	Domainoid score	I5786
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47996
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42950
orthoMCL	1	0.900	-	-		OOG6_102891
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1195
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.720