DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drpr and Megf11

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	XP_038938374.1	Gene:	Megf11 / 691517	RGDID:	1582797	Length:	1139	Species:	Rattus norvegicus

Alignment Length:	1119	Identity:	379/1119 - (33%)
Similarity:	532/1119 - (47%)	Gaps:	135/1119 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ILIACLAQLVLAQADLKDLDGPNICKRRELYNVDVVYTELQSFQERGSTWCVTFPP--RCSTYRI 67
            :|:..|.|..||    .:.:.||:|...|.|.|.|..:....|.:...|.|.....  :|:.:||
  Rat     8 LLVVFLLQAALA----LNPEDPNVCSHWESYAVTVQESYAHPFDQIYYTRCADILNWFKCTRHRI 68

  Fly    68 KHRVVNK--TKTIAKNRIVRDCCDGYIASAGECVPHCSEPCQHGRCISPEKCKCDHGYGGPACDI 130
            .::...:  .:|:.:.|  ..||.||..:...|:|.|:|.|.||||:||:.|.|:.|:|||.|..
  Rat    69 SYKTAYRRGLRTMYRRR--SQCCPGYYENGDFCIPLCTEECMHGRCVSPDTCHCEPGWGGPDCSS 131

  Fly   131 NCPPGWYGRNCSMQCDCLNNAVCEPFSGDCECAKGYTGARCADICPEGFFGANCSEKCRCENGGK 195
            .|....:|.:||.:|.|.|.|:|.|.:|.|.||.|:.|.||.:.|..|..|..|...|:|.:|..
  Rat   132 GCDSEHWGPHCSNRCQCQNGALCNPITGACVCAPGFRGWRCEEFCAPGTHGKGCQLLCQCHHGAS 196

  Fly   196 CHHVSGECQCAPGFTGPLCDMRCPDGKHGAQCQQDCPCQNDGKCQPETGACMCNPGWTGDVCANK 260
            |...:|||.||||:||..|:..||.|.|||.|:..|||||.|.|...||.|.|.|||||.|||..
  Rat   197 CDPRTGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCAQP 261

  Fly   261 CPVGSYGPGCQESCECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCDCANDAMC 325
            ||.|::|..|.:.|.|:.|..|.|:||||.|..||.|:||.:||...|:||.||..|||.|...|
  Rat   262 CPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGTFGFRCSQRCDCHNGGQC 326

  Fly   326 DRANGTCICNPGWTGAKCAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSAQCT 390
            ..|.|.|.|.||:.|..|.||:|....:|..|...|.||.|:|..|||.||.|.|..|||...|.
  Rat   327 SPATGACECEPGYKGPSCQERLCPEGLHGPGCTSPCPCDTENTISCHPVTGACTCQPGWSGHYCN 391

  Fly   391 RPCTFLRYGPNCELTCNCKNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQNGA 455
            ..|....||..|:|.|.|:|||.|..:.|:|.||||:.|..|...|..||:|.:|:..|.|.||.
  Rat   392 ESCPAGYYGNGCQLPCTCQNGADCHSITGSCTCAPGFMGEVCAVPCAAGTYGPNCSSVCSCSNGG 456

  Fly   456 KCEPETGQCLCTAGWKNIKCDRPCDLNHFGQDCAKVCDCHNNAACNPQNGSCTCAAGWTGERCER 520
            .|.|..|.|.|..||:.:.|..||....:|.:|.:.|.|.|.|||:|.:|||.|..||.|:.||.
  Rat   457 TCSPVDGSCTCREGWQGLDCSLPCPSGTWGLNCNESCVCANGAACSPFDGSCACTPGWLGDSCEL 521

  Fly   521 KCDTGKFGHDCAQKCQCDFNNSLACDATNGRCVCKQDWGGVHCETNCRSGYYGENCDKVCRCLNN 585
            .|..|.||.:|::.|.|  :::..||...|.|.|...|.|:.|::.|..|.:|.||...|.|.|.
  Rat   522 PCPDGTFGLNCSEHCDC--SHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENG 584

  Fly   586 SSCDPDSGNCICSAGWTGADCAEPCPPGFYGMECKERCPEILHGNKSCDHITGEILCRTGYIGLT 650
            .||.|..|:|.|:.|:.|..|...|||||||..|.:.||..:|....|.|::|...|..|:.|..
  Rat   585 GSCSPVDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSRGPCHHVSGICECLPGFSGAL 649

  Fly   651 CEHPCPAGLYGPGCKLKCNCEHGGECNHVTGQCQCLPGWTGSNCNESCPTDTYGQGCAQRCRCVH 715
            |...|..|.:|..|...|:|.:.|.|:.:.|.|||.|||||.:|:::||:..:|..|...|.|.:
  Rat   650 CNQVCAGGHFGQDCAQLCSCANNGTCSPIDGSCQCFPGWTGKDCSQACPSGFWGSACFHTCSCHN 714

  Fly   716 HKVCRKADGMCICETGWSGTRCDEVCPEGFYGEHCMNTCACPSANFQCHAAHGCVCRSGYTGDNC 780
            ...|...||.|.|..||:|..|.:.||..|:|:.|.:.|.|.:.....|....|.||:|::|.:|
  Rat   715 GASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGHICQCQNGASCDHITGKCTCRTGFSGRHC 779

  Fly   781 DELIA-------SQRIADQSENSS----------------------------------------- 797
            ::..|       .|::.:...|::
  Rat   780 EQRCAPGTFGYGCQQLCECMNNATCDHVTGTCYCSPGFKGIRCDQAALMMDELNPYTKISPALGA 844

  Fly   798 -RASV-ALTLVLMTLF-ACIIFAVFIYYRRRVSNLKTEIA-HVHYT---------HDTNPPSWPP 849
             |.|| |:|.:::.|| ..::..:|.:.|||......::| .|.||         :..:..|...
  Rat   845 ERHSVGAVTGIILLLFLVVVLLGLFAWRRRRQKEKGRDLAPRVSYTPAMRMTSTDYSLSDLSQSS 909

  Fly   850 NHN--FDNPVY---------GMQAETRLLPNNMRSKMNN--FDQRSTMSTDYGDDCNASGRVGSY 901
            :|.  |.|..|         ..||.|  |..|..:|::|  .|:.:...|.|           ||
  Rat   910 SHAQCFSNASYHTLACGGPATSQAST--LDRNSPTKLSNKSLDRDTAGWTPY-----------SY 961

  Fly   902 SINYNHDLLTKNLNADRTNPIVYNESLKEEHVYDEIKHKEGYKDPVKIYSKILFPEDEYDHL--- 963
            ....:.......|.| |..|         |..|.|::|...:.:|   :|......|...:.
  Rat   962 VNVLDSHFQISALEA-RYPP---------EDFYIELRHLSRHAEP---HSPGTCGMDRRQNTYIM 1013

  Fly   964 -----DYSRPSTSQKPHYHRMNDAMLNINQDEEKPSNVKNMTVLLNKPLPPTE----PEPQHECF 1019
                 ||.:.|.        .:.:..::|..|...:.:|:..:|..| ||.:.    ..|.|  .
  Rat  1014 DKGFKDYMKESV--------CSSSTCSLNSSENPYATIKDPPILTCK-LPESSYVEMKSPVH--M 1067

  Fly  1020 DNTNTNLDNVSTAS 1033
            .:..|::.::||::
  Rat  1068 GSPYTDVPSLSTSN 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877	17/68 (25%)
		EGF_CA	274..319	CDD:304395	23/44 (52%)
		DSL	<479..518	CDD:302925	17/38 (45%)
		DSL	<567..606	CDD:302925	16/38 (42%)
Megf11	XP_038938374.1	EMI	26..93	CDD:400092	17/68 (25%)
		EGF_CA	189..234	CDD:419698	22/44 (50%)
		Laminin_EGF	275..320	CDD:395007	23/44 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I5986
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13031
Inparanoid	1	1.050	798	1.000	Inparanoid score	I480
OMA	1	1.010	-	-		QHG47996
OrthoDB	1	1.010	-	-		D34806at33208
OrthoFinder	1	1.000	-	-		FOG0001631
OrthoInspector	1	1.000	-	-		otm45018
orthoMCL	1	0.900	-	-		OOG6_102891
Panther	1	1.100	-	-	O	PTHR24035
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1195
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980