DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drpr and Megf6

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_075244.1	Gene:	Megf6 / 65049	RGDID:	621188	Length:	1574	Species:	Rattus norvegicus

Alignment Length:	772	Identity:	296/772 - (38%)
Similarity:	406/772 - (52%)	Gaps:	38/772 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DLDG--PNICKRRELYNVDVVYTEL-QSFQERGSTWCVTFPPRCSTYRIKHRVVNKTKTIAKNRI 83
            ||||  |.:   |.|.::.|:..|| :.||:   .:........:..|.:|       |:.:..:
  Rat   463 DLDGRLPFV---RPLPHIAVLRDELPRLFQD---DYGAEEEAAAAELRGEH-------TLTEKFV 514

  Fly    84 VRDCCDGYIASAGECVPHCSEPCQHGRCISP--EKCKCDHGYGGPACDINCPPGWYGRNCSMQCD 146
            ..|...|:     :|...|.: |::|....|  :.|.|..|:.|..|:..|||..:|:|||..|.
  Rat   515 CLDHSFGH-----DCSLTCDD-CRNGGTCFPGQDGCDCPEGWTGIICNETCPPDTFGKNCSSPCT 573

  Fly   147 CLNNAVCEPFSGDCECAKGYTGARCADICPEGFFGANCSEKCRCENGGKCHHVSGECQCAPGFTG 211
            |.|...|:|..|.|.|..|.:||.|.|.||:||:|.:|.:||.|.|.|:||.:.|.|.|.||..|
  Rat   574 CQNGGTCDPVLGACRCPPGVSGAHCEDGCPKGFYGKHCRKKCHCANRGRCHRLYGACLCDPGLYG 638

  Fly   212 PLCDMRCPDGKHGAQCQQDCPCQ--NDGKCQPETGACMCNPGWTGDVCANKCPVGSYGPGCQESC 274
            ..|.:.||....|..|.:||.|:  :...|.|:.|:|.|..|:.|:.|..:|..|.:||||:..|
  Rat   639 RFCHLACPPWAFGPGCSEDCLCEQSHTRSCNPKDGSCSCKAGFQGERCQAECESGFFGPGCRHRC 703

  Fly   275 ECYKGAPCHHITGQC--ECPPGYRGERCFDECQLNTYGFNCSMTCDCANDAMCDRANGTCICNPG 337
            .|..|..|..::|:|  :|||||:||.|..||.:.|:|.|||.:|.|.. |.|.|..|.|:|.||
  Rat   704 TCQPGVACDPVSGECRTQCPPGYQGEDCGQECPVGTFGVNCSGSCSCVG-APCHRVTGECLCPPG 767

  Fly   338 WTGAKCAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSAQCTRPCTFLRYGPNC 402
            .||..|... |...::||.|...|.. .||...|:||||.|.|..|:..::|...|:...||..|
  Rat   768 KTGEDCGAD-CPEGRWGLGCQEICPA-CEHGASCNPETGTCLCLPGFVGSRCQDTCSAGWYGTGC 830

  Fly   403 ELTCNCKNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQNG-AKCEPETGQCLC 466
            ::.|.|.|...|.|..|.|.|||||.|.:|:.:|:.|.:|.||...|:|..| ..|:..:|.|||
  Rat   831 QIRCACANDGHCDPTTGRCSCAPGWTGLSCQRACDSGHWGPDCIHPCNCSAGHGNCDAVSGLCLC 895

  Fly   467 TAGWKNIKCDRPCDLNHFGQDCAKVCDCHNNAACNPQNGSCTCAAGWTGERCERKCDTGKFGHDC 531
            .||::..:|::.|...::|..|.:.|.|.:.|||:..:|:|||.|||.|..||..|..|.||.||
  Rat   896 EAGYEGPRCEQSCRQGYYGPSCEQKCRCEHGAACDHVSGACTCPAGWRGSFCEHACPAGFFGLDC 960

  Fly   532 AQKCQCDFNNSLACDATNGRCVCKQDWGGVHCETNCRSGYYGENCDKVCRCLNNSSCDPDSGNCI 596
            ...|.|  :....|||..|.|:|.....|..|..:|....:|.||.::|.|.|.:|||..:|.|.
  Rat   961 DSACNC--SAGAPCDAVTGSCICPAGRWGPRCAQSCPPLTFGLNCSQICTCFNGASCDSVTGQCH 1023

  Fly   597 CSAGWTGADCAEPCPPGFYGMECKERCPEILHGNKSCDHITGEILCRTGYIGLTCEHPCPAGLYG 661
            |:.||.|..|.:.||||.||..|:..|  :......||.|.|:..|..|:.||.||:.|..|.|.
  Rat  1024 CAPGWMGPTCLQACPPGLYGKNCQHSC--LCRNGGRCDPILGQCTCPEGWTGLACENECLPGHYA 1086

  Fly   662 PGCKLKCNCEHGGECNHVTGQCQCLPGWTGSNCNESCPTDTYGQGCAQRCRCVHHKVCRKADGMC 726
            .||:|.|:|.|||.|:.:||.|.|..||||..|..||.:.|:|..|.:.|.|.....|....|.|
  Rat  1087 AGCQLNCSCLHGGICDRLTGHCLCPAGWTGDKCQSSCVSGTFGVHCEEHCACRKGASCHHVTGAC 1151

  Fly   727 ICETGWSGTRCDEVCPEGFYGEHCMNTCACPSANFQCHAAHG-CVCRSGYTGDNCDE 782
            .|..||.|..|::.||.|::||.|...|.||: |..||...| |.|..|:||.:|::
  Rat  1152 FCPPGWRGPHCEQACPRGWFGEACAQRCLCPT-NASCHHVTGECRCPPGFTGLSCEQ 1207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877	12/65 (18%)
		EGF_CA	274..319	CDD:304395	22/46 (48%)
		DSL	<479..518	CDD:302925	16/38 (42%)
		DSL	<567..606	CDD:302925	16/38 (42%)
Megf6	NP_075244.1	EMI	42..112	CDD:284877
		FXa_inhibition	127..162	CDD:291342
		vWFA	<154..202	CDD:294047
		vWFA	<237..285	CDD:294047
		vWFA	<284..325	CDD:294047
		FXa_inhibition	338..373	CDD:291342
		vWFA	<371..410	CDD:294047
		vWFA	<413..452	CDD:294047
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1555..1574
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	78	1.000	Domainoid score	I8620
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24035
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910