DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drpr and RET

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_066124.1	Gene:	RET / 5979	HGNCID:	9967	Length:	1114	Species:	Homo sapiens

Alignment Length:	398	Identity:	82/398 - (20%)
Similarity:	122/398 - (30%)	Gaps:	139/398 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 KRRE--------LYNVDVV---------YTELQSFQERGSTWCVTFPPRCSTYRIKHRVVNKTKT 77
            ||:|        :::.|||         ||   |....|.||..      .|:|::| ..|:|..
Human   286 KRKEDTVVATLRVFDADVVPASGELVRRYT---STLLPGDTWAQ------QTFRVEH-WPNETSV 340

  Fly    78 IAKNRIVRDCCDGYIASAGECVPHCSEPCQHGRCISPEKCKCDHGYGGPACDI-----NCP---- 133
            .|....||.....|     ..|.:.:......|.:.......|..:.||...:     |..
Human   341 QANGSFVRATVHDY-----RLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPV 400

  Fly   134 ----PGWYGRNCSMQCD--------CLNNAVCEPFSG-DCECAKGYTGARCADI-------CPEG 178
                |..|..:.|.:..        |:.|  |:.||| :.:.....:||.|:.:       ...|
Human   401 SLHLPSTYSLSVSRRARRFAQIGKVCVEN--CQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSG 463

  Fly   179 FFGANCSEKCRCENGGKCHHV----------SGECQCAPGFTGPL------CDMRCPDGKHGAQC 227
            ....|.::..|.....:.|::          ..:.|......|..      |.:.|...|...:|
Human   464 ILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLEC 528

  Fly   228 QQDCPC-------------QNDGK--------CQPETGAC---MCNPGWTGDVCANKCP------ 262
            ::   |             |.|||        |.|.|..|   .|:...|.|:  |.||
Human   529 EE---CGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDI--NICPQDCLRG 588

  Fly   263 --VGSYGPGCQESCECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCDCANDAMC 325
              ||.:.||..      :|....:  |.|.|.|  ..|:||.|             .:...|.:|
Human   589 SIVGGHEPGEP------RGIKAGY--GTCNCFP--EEEKCFCE-------------PEDIQDPLC 630

  Fly   326 DRANGTCI 333
            |....|.|
Human   631 DELCRTVI 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877	20/78 (26%)
		EGF_CA	274..319	CDD:304395	9/44 (20%)
		DSL	<479..518	CDD:302925
		DSL	<567..606	CDD:302925
RET	NP_066124.1	Cadherin	172..261	CDD:278457
		PTKc_RET	723..1012	CDD:173631
		Pkinase_Tyr	724..1005	CDD:285015
		Inhibitors binding	805..807
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900