Protein Alignment drpr and pear1

DIOPT Version :10

• Sequence 1: NP_001261276.1
• Gene: drpr / 38218
• FlyBaseID: FBgn0027594
• Length: 1042
• Species: Drosophila melanogaster
• Sequence 2: XP_700533.4
• Gene: pear1 / 571812
• ZFINID: ZDB-GENE-091230-1
• Length: 1020
• Species: Danio rerio
• Alignment Length: 1081
• Identity: 351/1081 - (32%)
• Similarity: 502/1081 - (46%)
• Gaps: 149/1081 - (13%)

  Fly     4 VILIACLAQLVLAQADLKDLDGPNICKRRELYNVDVVYTELQSFQERGSTWCVTFPPRCSTYRIK 68
            :.::.|:.:|.|: .|.:|   ||:|...|.:...|..:..|.|.:.....|  ..|..:....:
Zfish    10 LFVLGCVCELSLS-LDPRD---PNVCSLWESFTTSVKESYAQPFDQMSEEPC--SEPWSANKCTR 68

  Fly    69 HRVVNKT--KTIAKNRIVR--DCCDGYIASAGECVPHCSEPCQHGRCISPEKCKCDHGYGGPACD 129
            ||:..||  :.:.|....|  .||.|:..|..:|||.|::.|.||||::|::|:|:.|:.|..|.
Zfish    69 HRITYKTLYRQVVKMDYRRRYQCCPGFYESRNKCVPRCTKECVHGRCVAPDRCQCEMGWRGDDCS 133

  Fly   130 INCPPGWYGRNCSMQCDCLNNAVCEPFSGDCECAKGYTGARCADICPEGFFGANCSEKCRCENGG 194
            .:|....:|..|...|:|.|...|:..:|:|:|..||||..|.|.||..:||..|.::|:|..||
Zfish   134 SSCDGQHWGPGCRRLCECQNGGECDVLTGNCQCPAGYTGQHCHDPCPVKWFGQGCRQECQCGTGG 198

  Fly   195 KCHHVSGECQCAPGFTGPLCDMRCPDGKHGAQCQQDCPCQNDGKCQPETGACMCNPGWTGDVCAN 259
            .|:..:|||.|..||||.||:..||..|   :|...|||||.|.|| ..|.|:|.|||.|.||..
Zfish   199 ICNQTTGECVCKQGFTGTLCEESCPRPK---RCAARCPCQNGGICQ-GNGVCLCPPGWMGPVCTE 259

  Fly   260 KCPVGSYGPGCQESCECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCDCANDAM 324
            :||.|.:|..|.:.|.|:.|..|....|||:|..||.||||.:||.:.|||.:|...|||||.|.
Zfish   260 RCPPGRFGINCSKDCLCHNGGHCDQEKGQCQCDAGYTGERCNEECPVGTYGEDCKGVCDCANGAR 324

  Fly   325 CDRANGTCICNPGWTGAKCAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSAQC 389
            |...:|.|:|.||:.|.:|..|:|....:|:.|...|.|:..:|..|||..|.|.|..||:...|
Zfish   325 CYNIHGGCLCEPGFKGPRCDHRMCPEAVFGMHCQHRCLCNPLNTLSCHPLKGECTCQPGWAGLYC 389

  Fly   390 TRPCTFLRYGPNCELTCNCKNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQNG 454
            ...|....||..|...|.|.||..|..|.|.|.|.||:.|..||:.||.|.:|:.|...|.|.|.
Zfish   390 NETCAQGYYGNGCLEPCLCVNGGVCDSVTGQCHCPPGFTGLHCEKLCEDGFYGKGCLSACKCVNS 454

  Fly   455 AKCEPETGQCLCTAGWKNIKCDRPCDLNHFGQDCAKVCDCHNNAACNPQNGSCTCAAGWTGERCE 519
            ..|.|..|.|:|..||:...|...|....:|..|.:.|.|.|.|:|:|.:|||.|.|||.|..|:
Zfish   455 IVCSPVDGACICKEGWRGPDCSIACSEGTWGPGCNRTCKCTNGASCDPADGSCKCTAGWRGASCD 519

  Fly   520 RKCDTGKFGHDCAQKCQCDFNNSLACDATNGRCVCKQDWGGVHCETNCRSGYYGENCDKVCRCLN 584
            ..|..|.||..|..:|.|..:.  .|::..|:|:|...|.||.|...|..|.:|..|::.|.|||
Zfish   520 EPCLIGTFGPGCQNQCDCVHDE--GCESVTGQCLCLPGWTGVRCTQQCPEGTWGIQCNQTCSCLN 582

  Fly   585 NSSCDPDSGNCICSAGWTGADCAEPCPPGFYGMECKERCPEILHGNKSCDHITGEILCRTGYIGL 649
            :::|...:|.|:|.             |||:|.:
Zfish   583 SATCQAHTGTCLCK-------------PGFWGAQ------------------------------- 603

  Fly   650 TCEHPCPAGLYGPGCKLKC-NCEHGGECNHVTGQCQCLPGWTGSNCNESCPTDTYGQGCAQRCRC 713
             |:|.|.|||:|..|...| .|.|...|:|:||.||||.|:||..|.::||...||..|:..|||
Zfish   604 -CQHMCSAGLFGEKCSRHCPPCVHASSCHHITGDCQCLSGYTGPLCEQACPVGRYGSHCSNVCRC 667

  Fly   714 VHHKVCRKADGMCICETGWSGTRCDEVCPEGFYGEHCMNTCACPSANFQCHAAHG-CVCRSGYTG 777
            .::..|....|:|||..||:|:.|..:|..|.:|.:|..||:|| .|..|...:| |||..| .|
Zfish   668 TNNATCHHEVGLCICPAGWTGSDCSLLCQAGTFGINCAQTCSCP-PNHSCDPHNGDCVCEPG-PG 730

  Fly   778 DNC--DELIASQRIADQSENSSRASVALTLVLMTLFACIIFAVFIYYRRR----------VSNLK 830
            :.|  ::.::........|..|..::| .:|::.:...::.||.:.||||          ||...
Zfish   731 EACKPEQELSVMVPVSPVERDSWGAIA-GIVVLVILVVLLLAVLLLYRRRQQDKQSNTPVVSFSS 794

  Fly   831 TEIAHVHYTHDTNPPSWPPNHNFDNPVYGMQAETR----LLPNNMRSKMNN-----FDQRSTMST 886
            |......|.....|.|:  :|.:.||.|...::.|    .||||....:.|     |.....|..
Zfish   795 TRTVSSEYAVPDVPHSY--HHYYSNPSYHTLSQNRPPLPHLPNNQDRAIKNTNNQLFCSLKNMER 857

  Fly   887 D----YGDDCNAS--------------GRVG-----SYSI----NYNHDLLTKNLNADRTNPIVY 924
            :    :..|.||:              |..|     |||.    :||.:|....:       .|.
Zfish   858 ERRGLFTADTNATLPPGWKHQEPPKDPGAFGIDRSYSYSATLGKHYNKELKDSCV-------AVS 915

  Fly   925 NESLKEEHVYDEIKHKEGYKDPVKIYSKILFPEDEYDHLDYSRPSTSQKPHYHRMNDAMLNI--- 986
            :.||..|:.|..||...|.        .:..||..|..:..:.|  .|:.:...::..::..
Zfish   916 SSSLNSENPYATIKDLPGL--------PVCPPESSYMEMKSAVP--RQRSYTQIISPPLMTAPAL 970

  Fly   987 ---------NQDEEKPSNVKNMTVLLNKP----LPPTEPEP 1014
                     |.:|::..|..::.:..:.|    |||....|
Zfish   971 PCTGHCSLSNAEEQELQNHYDLPINSHIPGHYDLPPVRRPP 1011

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	26..92	CDD:462204	18/69 (26%)
		EGF_CA	274..319	CDD:473889	21/44 (48%)
		gliding_CglD	<451..579	CDD:468178	47/127 (37%)
		DSL	567..609	CDD:473190	12/41 (29%)
pear1	XP_700533.4	EMI	28..97	CDD:462204	18/70 (26%)
		Laminin_EGF	411..451	CDD:395007	17/39 (44%)