DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drpr and stab1

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_001182543.1	Gene:	stab1 / 570626	ZFINID:	ZDB-GENE-050208-554	Length:	2553	Species:	Danio rerio

Alignment Length:	1214	Identity:	249/1214 - (20%)
Similarity:	350/1214 - (28%)	Gaps:	488/1214 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 CVTFPPRCSTYRIKH----RVVNKTKTIAKNRIVRDCCDG-YIASAGECVPHCSEPCQ-HGRCI- 112
            |...|.|..:|.|..    :..|.|:|..:      ||.| |......|:.....||. .|.|.
Zfish   678 CEPLPDRRFSYSIFEEGCAKYCNITETSPQ------CCRGFYGPDCKPCIGGFQNPCYGKGTCFD 736

  Fly   113 ---SPEKCKCDHGYGGPACDINCPPGWYGRNCSMQCDCLNNAVCEPFSGDCECAKGYTGARCADI 174
               ....|||:..:.|..|.:...|..:|.||...|.|::        |.|:...|.:|......
Zfish   737 GINGNGSCKCEAAFTGVGCHLCSNPKKHGENCDEDCRCVH--------GVCDNRPGSSGVCRRGS 793

  Fly   175 CPEGFFGANCSEKCR-CENGG---KCH------HVSGE--CQCAPGFTGPLCDMRCPDGKHGAQC 227
            |.|||.|..|.:... |::.|   .||      :|.|:  |.|.||:.|           .|..|
Zfish   794 CFEGFLGELCDQTASVCDSDGALLHCHIHAICLYVKGQTTCVCQPGYEG-----------DGYAC 847

  Fly   228 QQDCP--------CQNDGKCQPETGA--CMCNPGWTGD--VCA--NKCPVGSYGPGCQESCECYK 278
            .:..|        |..:..|....|.  |:|..|||||  :|.  |.|.:.|.| ||.|:.:|..
Zfish   848 TESNPCLLPQRGGCDTNAVCSYNAGKVNCVCMEGWTGDGSLCVEINNCQLESRG-GCHENADCTS 911

  Fly   279 GAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCDCANDAMCDRANGTC-------ICNP 336
            .||..:   :|.|..||.|:           |..|.:...|.:|      ||.|       :.:|
Zfish   912 TAPGQN---ECSCKKGYMGD-----------GIICKIVNPCLSD------NGGCHSLAKCKLTSP 956

  Fly   337 GWTGAKCAERICEANKYGLDC-----------------------NRTCECDMEHTDL-------- 370
            |.....|..   |....||.|                       ::..|.|.:.|.|
Zfish   957 GTRECTCPS---EFEGDGLSCYGNMLVELDGNSEFYYFNRFLQRHKVIETDSQVTALVPSKAAFK 1018

  Fly   371 ---------------------------------CHPETGNCQCSIG---W-----------SSAQ 388
                                             ...:.|....:||   |           |:|.
Zfish  1019 NLSDLEESFWFDYYRLPHLLQVHFLEGIYTSEDLRQKAGKTVQTIGMTKWEVQSNGRELMISNAT 1083

  Fly   389 -----------CTR----------------PCTFLRYGPN---------CELTCNCKNG------ 411
                       |..                |.|.:::..|         ..|..|.:|.
Zfish  1084 ILVPDIKAINGCIHIIDTVLRPPLSDFPPPPPTLMKFLNNTPEFSLFRQAALLYNLENSIPTRDY 1148

  Fly   412 ----------------------------------------------------------------- 411

Zfish  1149 TILIPYDSAVQEYLIKTNATQLSKEIVKYHVILSEQLFPEHLSDRLFKNTFLGNGTQIMFFVDIE 1213

  Fly   412 ----AKCSPVN-------------------------------------GTCLCAPGWRGPTCEES 435
                |...|||                                     |.|..|     |.|..|
Zfish  1214 NQIIANDVPVNMSYIETRHGIVFGIPRVLDLHKNHCSKDVILKITGRCGDCKAA-----PQCPFS 1273

  Fly   436 CEP--GTFGQDCALRCDCQN--GAKCEPETG---QCLCTAGWKNIKCDRPCDLNHFGQDCAKVCD 493
            .:|  ..|.|:....|..:.  |.|.:..:|   .||.|..      |..|...:||.||.| |.
Zfish  1274 AKPTQPKFPQNMKSNCKYRTRVGKKRKTVSGCLMDCLRTTK------DHSCCPGYFGHDCGK-CP 1331

  Fly   494 ------CHNNAACNP---QNGSCTCAAGWTGERCERKCDTGKFGHDCAQKCQCDFNNSLACDATN 549
                  |.||..|..   ..|.|.|..|:.|..|| .|:.|::|.||..:|.|:....|.....|
Zfish  1332 GTLDNWCSNNGQCEDGLHGTGKCLCNEGFHGTACE-MCEPGRYGKDCKSECHCEHGKCLDGLEGN 1395

  Fly   550 GRCVCKQDWGGVHCETNCRSGYYGENCDKVCRCLNNSSCDPDSGNCICSAGW--TGADCAE--PC 610
            |:|:|.:.|.||.|.........|..||....|::..|..|.:  |.|:||:  .|..|.|  ||
Zfish  1396 GQCICFKGWKGVKCSVVVVDDACGGVCDVNANCISGDSGTPPT--CSCTAGYKGNGTSCEEINPC 1458

  Fly   611 PPGFYGMECKERCPEILHGNKSCDHITGEILCRTGYI--GLTCEHPCPAGLYGPGCKLKCNCEHG 673
            .....|......|.:...|.::|       .|.|.||  |:.|.......:...||.....|...
Zfish  1459 AEDNGGCSVNANCTKTAPGERTC-------TCTTNYIGDGVICVEMDACLVNNGGCDENAICMKT 1516

  Fly   674 GECNHVTGQCQCLPGWTGSNCNESCPTDTYGQGCAQRCRCVHHKVCRKADGMC----ICETGWSG 734
            |. |.|.  |.|.||:                 .:|..||:....|||.:|.|    :|....:|
Zfish  1517 GP-NRVA--CACRPGF-----------------ISQGHRCLAVNPCRKDNGGCSVNAVCRYLGAG 1561

  Fly   735 TRCDEVCPEGFYGEHCMNTCACPSANFQCHAAHGCVCRSGYTGDNCDELIASQRIADQSENSSRA 799
            .|                               .|.|..|:.||..      |.....|...||.
Zfish  1562 ER-------------------------------NCTCYIGFKGDGL------QCAGTVSREISRN 1589

  Fly   800 SVALTLVLMTLFACIIFAVFIYYRRRVSNLKTE-----------IAHVHY-THDTNP--PSW-PP 849
            ..|:                 ::|..:...:..           :.|..| |:.:||  .|| ..
Zfish  1590 PEAM-----------------WFRNNLGAFRFRDWVGRGPFTVFVPHADYVTNFSNPQVDSWINS 1637

  Fly   850 NHNFDNPVYGMQAETRLLPNNMRSKMNNFDQRSTMSTDYGDDCNASGRVGSYSINYNHDLLTKNL 914
            :|:.:...|.:.:...|..::::|.       ..:.|..|.....|.|.|...||.|..::|.::
Zfish  1638 SHSSELLRYHIVSCEELHLSDLKSV-------KEVVTANGYKLRFSVRDGVVYINDNTKIITSDI 1695

  Fly   915 NADRTNPIVYNESLKEEHVYDEIKHKEGYKDPVKIYSKILFPED 958
            ..  :|.|::                  |.|      |:|.|.|
Zfish  1696 EC--SNGILH------------------YID------KVLIPYD 1713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877	11/41 (27%)
		EGF_CA	274..319	CDD:304395	10/44 (23%)
		DSL	<479..518	CDD:302925	16/47 (34%)
		DSL	<567..606	CDD:302925	11/40 (28%)
stab1	NP_001182543.1	EGF_3	227..257	CDD:289699
		Fasciclin	379..475	CDD:295423
		FAS1	455..630	CDD:225214
		Fasciclin	504..630	CDD:280607
		EGF_3	819..847	CDD:289699	10/38 (26%)
		EGF_3	859..889	CDD:289699	10/29 (34%)
		EGF_3	901..932	CDD:289699	13/45 (29%)
		EGF_3	938..974	CDD:289699	11/44 (25%)
		Fasciclin	1002..1103	CDD:280607	11/100 (11%)
		Fasciclin	1125..1242	CDD:295423	7/116 (6%)
		EGF_3	1458..1494	CDD:289699	10/42 (24%)
		EGF_3	1500..1536	CDD:289699	11/55 (20%)
		EGF_3	1542..1578	CDD:289699	13/72 (18%)
		Fasciclin	1611..1711	CDD:280607	26/132 (20%)
		Fasciclin	1734..1864	CDD:280607
		EGF_3	2085..2120	CDD:289699
		EGF_3	2128..2163	CDD:289699
		Link_domain_TSG_6_like	2198..2290	CDD:239592
		Fasciclin	2322..2448	CDD:295423
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900