DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drpr and megf11

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	XP_009291879.1	Gene:	megf11 / 563468	ZFINID:	ZDB-GENE-060503-252	Length:	1114	Species:	Danio rerio

Alignment Length:	1052	Identity:	376/1052 - (35%)
Similarity:	521/1052 - (49%)	Gaps:	114/1052 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LPVILIACLAQLVLAQADLKDLDGPNICKRRELYNVDVVYTELQSFQERGSTWCVTFPP--RCST 64
            |||:.:   ..|:::...|.. |.||:|...|.|.|.|..:....|.:...|.|.....  :|:.
Zfish    11 LPVLAV---LGLIISAWSLNP-DDPNVCSHWESYAVTVQESYAHPFDQIYYTRCTDILNWFKCTR 71

  Fly    65 YRIKHRVVNK--TKTIAKNRIVRDCCDGYIASAGECVPHCSEPCQHGRCISPEKCKCDHGYGGPA 127
            :|..::...:  .:|:.:.|  ..||.||..|...|||.|||.|.||||:||:.|:|:.|:||..
Zfish    72 HRTSYKTAYRRGVRTMYRRR--SQCCPGYFESGDLCVPRCSEECAHGRCVSPDTCQCEPGWGGLD 134

  Fly   128 CDINCPPGWYGRNCSMQCDCLNNAVCEPFSGDCECAKGYTGARCADICPEGFFGANCSEKCRCEN 192
            |...|..|::|.:||.:|.|.|.|:|.|.:|.|.|..||.|.||.|:|..|::|..|..:|:|.|
Zfish   135 CSSGCESGYWGPHCSNRCQCKNGALCNPITGACVCTDGYQGWRCEDLCEPGYYGKGCQLQCQCLN 199

  Fly   193 GGKCHHVSGECQCAPGFTGPLCDMRCPDGKHGAQCQQDCPCQNDGKCQPETGACMCNPGWTGDVC 257
            |..|||.:|||.||||:.||:|..|||.|.||.||:|.|||||.|.|...||.|.|..||||.||
Zfish   200 GATCHHETGECICAPGYMGPICGERCPSGSHGPQCEQRCPCQNGGTCHHITGECSCPAGWTGSVC 264

  Fly   258 ANKCPVGSYGPGCQESCECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCDCAND 322
            |..||.|.||..|.:.|.|..|..|.||||||:|..||.|.||.:||.:.|||..|::.|||.|.
Zfish   265 AQPCPFGKYGINCSKECSCRNGGLCDHITGQCQCMAGYSGHRCQEECPVGTYGPQCTLHCDCQNG 329

  Fly   323 AMCDRANGTCICNPGWTGAKCAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSA 387
            |.|...||.|:|:.|:.|..|.:|.|....|||.|::.|.|:..:|..|||.||.|.|:.||:..
Zfish   330 AKCYHINGACLCDTGFKGHHCQDRFCPPGLYGLICDKYCPCNSTNTISCHPLTGECSCTAGWTGL 394

  Fly   388 QCTRPCTFLRYGPNCELTCNCKNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQ 452
            .|...|....||..|.:.|.|.|||.|..:.|.|:||||:.|..|.::|..|.||.:|...|.|.
Zfish   395 YCNETCPPGYYGEGCGVPCQCANGADCHSLTGACICAPGYTGDDCSQTCPSGLFGTNCTSICHCH 459

  Fly   453 NGAKCEPETGQCLCTAGWKNIKCDRPCDLNHFGQDCAKVCDCHNNAACNPQNGSCTCAAGWTGER 517
            |.|.|.|..|.|:|..||:.:.|...|....:|..|.:.|.|.|.|||:|.:|||||::||.|||
Zfish   460 NQASCSPIDGSCICKEGWQGVDCSILCSSGTWGLGCNQTCLCANGAACDPIDGSCTCSSGWRGER 524

  Fly   518 CERKCDTGKFGHDCAQKCQCDFNNSLACDATNGRCVCKQDWGGVHCETNCRSGYYGENCDKVCRC 582
            |::.|..|.:..:|.::|.|  |::..||..:|.|.|...|.|:||::.|..|::|.||...|.|
Zfish   525 CQQPCPDGTYELECRERCDC--NHADGCDHVSGLCRCLPGWTGIHCDSICPQGFWGSNCSMTCSC 587

  Fly   583 LNNSSCDPDSGNCICSAGWTGADCAEPCPPGFYGMECKERCPEILHGNKSCDHITGEILCRTGYI 647
            .|..||.|:.|.|:|:.|:.|..|...|||||||..|.:.||:.:|....|.|:||...|..|:.
Zfish   588 QNGGSCSPEDGTCVCAPGYRGTSCKRICPPGFYGHRCSQLCPQCVHSTGPCHHVTGHCECLAGFF 652

  Fly   648 GLTCEHPCPAGLYGPGCKLKCNCEHGGECNHVTGQCQCLPGWTGSNCNESCPTDTYGQGCAQRCR 712
            |..|...||:|.:|..|...|.|.:.|.||.:.|.|||.|||||.:|::.||...:|..|...|.
Zfish   653 GSLCNQVCPSGKFGKACAEICLCTNNGTCNPIDGSCQCFPGWTGDDCSQICPIGQWGPDCLNSCN 717

  Fly   713 CVHHKVCRKADGMCICETGWSGTRCDEVCPEGFYGEHCMNTCACPSANFQCHAAHGCVCRSGYTG 777
            |.:...|...||.|.|..||:|..|.:.||.||||..|...|.|.:.....|....|.||:|:.|
Zfish   718 CHNGAQCSAYDGECRCSLGWTGLYCTQRCPSGFYGRDCAEVCRCQNGADCDHITGQCACRTGFIG 782

  Fly   778 DNCDEL-------IASQRIADQSENSS-------------------------------------- 797
            .||::.       ...|::.:...|::
Zfish   783 TNCEQKCPPGTFGYGCQQLCECMNNATCDYVTGTCYCSPGYKGIRCDQAALVMEELNPYTKISPA 847

  Fly   798 ------RASVALTLVLMTLFACIIFAVFIYYRRRVSNLKTEIAHVHYT------------HDTNP 844
                  .|...:.::.:.|....:.::|:::|:|..:...|:..|.||            .:|:.
Zfish   848 LGSERQSAGAVMGIIFLLLIIMAMLSLFVWFRQRQRDKGQEMPSVSYTPALRVTNTDYSLSETSQ 912

  Fly   845 PSWPPNHNFDNPVYGMQAETRLLPNNMRSKMNNFDQRSTMSTDYGDDCNASGRVGSYSINYNH-- 907
            .| .....|.||.|...|:.    |...|..||.|  .|::...||..::..|  :| .|.|.
Zfish   913 SS-SSGQCFSNPSYHTVAQC----NISSSITNNLD--GTLTLKKGDRNSSEWR--AY-CNLNDLG 967

  Fly   908 ----DLLTKNLNADRTNPIVYNE-----------SLKEEHVYDEIKHKEGYKDPVKIYSKILFPE 957
                |.||  |..::|..:..:.           ||..|:.|..|      :||..:..|    .
Zfish   968 VSRGDTLT--LRDNKTTRMAKDYIKASMCSSSSCSLNSENPYATI------RDPPSLACK----H 1020

  Fly   958 DEYDHLDYSRPS 969
            .|..:::...|:
Zfish  1021 TESSYVEMKSPA 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877	16/68 (24%)
		EGF_CA	274..319	CDD:304395	23/44 (52%)
		DSL	<479..518	CDD:302925	19/38 (50%)
		DSL	<567..606	CDD:302925	16/38 (42%)
megf11	XP_009291879.1	EMI	32..98	CDD:311482	15/67 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7257
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13031
Inparanoid	1	1.050	815	1.000	Inparanoid score	I461
OMA	1	1.010	-	-		QHG47996
OrthoDB	1	1.010	-	-		D34806at33208
OrthoFinder	1	1.000	-	-		FOG0001631
OrthoInspector	1	1.000	-	-		otm25267
orthoMCL	1	0.900	-	-		OOG6_102891
Panther	1	1.100	-	-	O	PTHR24035
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1195
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.840