DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drpr and megf6b

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	XP_009304569.1	Gene:	megf6b / 557764	ZFINID:	ZDB-GENE-101112-3	Length:	1589	Species:	Danio rerio

Alignment Length:	694	Identity:	284/694 - (40%)
Similarity:	379/694 - (54%)	Gaps:	19/694 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 ECVPHCSEPCQHGRCISPEK--CKCDHGYGGPACDINCPPGWYGRNCSMQCDCLNNAVCEPFSGD 159
            :|...| |.|.:|...:..:  |.|..|:.|..|:..||.||:|||||:.|.|.|..||:|.||.
Zfish   548 DCSLSC-EDCVNGGVCNKHRNACDCPDGWTGVVCNETCPEGWFGRNCSLLCKCKNGGVCDPVSGS 611

  Fly   160 CECAKGYTGARCADICPEGFFGANCSEKCRCENGGKCHHVSGECQCAPGFTGPLCDMRCPDGKHG 224
            |.|..|.:|..|.|.||:|.:|..|:::|.|.|.|:||...|.|.|.||..|..|.:.||....|
Zfish   612 CRCPPGVSGELCQDGCPKGLYGKFCNKRCNCANNGRCHRTYGACLCDPGLYGRFCHLPCPKWMFG 676

  Fly   225 AQCQQDCPC--QNDGKCQPETGACMCNPGWTGDVCANKCPVGSYGPGCQESCECYKGAPCHHITG 287
            ..|.::|.|  ||..:|....|.|:|.||:.|..|.::|..|.:|..|:..|.|..|..|.|:||
Zfish   677 PGCSEECQCVQQNTIECHRHHGDCICKPGYRGHTCKDECESGFFGSACENKCSCPPGVTCDHVTG 741

  Fly   288 QCE--CPPGYRGERCFDECQLNTYGFNCSMTCDCANDAMCDRANGTCICNPGWTGAKCAERICEA 350
            .|:  ||.|..|::|..:|....:|..||.:|||:. |.||:..|.|.|..|..|.:| |:.|..
Zfish   742 ACQPKCPAGKTGDKCDQDCVEGRFGIGCSQSCDCSG-APCDKVTGQCTCPAGTFGKRC-EKECPE 804

  Fly   351 NKYGLDCNRTCE-CDMEHTDLCHPETGNCQCSIGWSSAQCTRPCTFLRYGPNCELTCNCKNGAKC 414
            .::||.|...|. |  |:...|....|.|.||.|:....|...|...|:|..|:|.|.|..|.:|
Zfish   805 GRWGLGCQEWCPVC--ENGGRCDRRNGTCVCSPGFIGRLCQNSCPAGRFGVGCQLRCVCDLGVRC 867

  Fly   415 SPVNGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQNG-AKCEPETGQCLCTAGWKNIKCDRP 478
            :||:|.|.|.|||.|..|.:.|:.|.:|.||...|||:|. ..|:.:||:|.|.||:...:||:.
Zfish   868 NPVSGRCSCPPGWTGHNCRKVCDAGRWGLDCESVCDCRNADGVCDAQTGRCHCEAGFTGARCDQK 932

  Fly   479 CDLNHFGQDCAKVCDCHNNAACNPQNGSCTCAAGWTGERCERKCDTGKFGHDCAQKCQCDFNNSL 543
            |....||..|...|.|.|.|:|:...|:|||..||||..||:.|..|.:|.||.|||.| .|..|
Zfish   933 CPAGSFGPGCKHRCQCENQASCDHVGGACTCKTGWTGTFCEKPCPQGFYGLDCQQKCVC-LNGGL 996

  Fly   544 ACDATNGRCVCKQDWGGVHCETNCRSGYYGENCDKVCRCLNNSSCDPDSGNCICSAGWTGADCAE 608
             ||..:|:|.||..|.|..|...|.:|::|.:|.:.|.|.||||||..||.|.|.|||||..|::
Zfish   997 -CDHVSGQCFCKAGWIGTRCNQTCPAGWFGVSCSQTCVCHNNSSCDAVSGQCECGAGWTGDTCSQ 1060

  Fly   609 PCPPGFYGMECKERCPEILHGNKSCDHITGEILCRTGYIGLTCEHPCPAGLYGPGCKLKCNCEHG 673
            .||.|.:|..|..||  :.....|||..:|...|.:|:.|..|:..||||.:|..|:.:|.|.:|
Zfish  1061 RCPAGVFGDGCVHRC--LCQNGASCDPESGHCFCPSGWTGAACQLECPAGRFGSDCQDRCECVNG 1123

  Fly   674 GECNHVTGQCQCLPGWTGSNCNESCPTDTYGQGCAQRCRCVHHKVCRKADGMCICETGWSGTRCD 738
            .:|:..||:|.|.|||||..|...|....:|.||..||:|.|..||....|.|:|..||.|.||:
Zfish  1124 AQCDGQTGRCVCPPGWTGERCENECERGWFGVGCEDRCQCDHGAVCHHVSGQCLCPAGWRGRRCE 1188

  Fly   739 EVCPEGFYGEHCMNTCACPSANFQCHAAHG-CVCRSGYTGDNCD 781
            :.|..|.:|:.|:..|:|||.: .||...| |.|..|:|||.|:
Zfish  1189 KACLPGSFGQDCVQRCSCPSGS-SCHHVTGHCGCAPGFTGDGCE 1231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395	18/46 (39%)
		DSL	<479..518	CDD:302925	17/38 (45%)
		DSL	<567..606	CDD:302925	21/38 (55%)
megf6b	XP_009304569.1	EMI	33..102	CDD:284877
		FXa_inhibition	152..187	CDD:291342
		vWFA	<184..227	CDD:294047
		FXa_inhibition	234..270	CDD:291342
		FXa_inhibition	276..311	CDD:291342
		vWFA	<308..350	CDD:294047
		FXa_inhibition	363..398	CDD:291342
		vWFA	<396..436	CDD:294047
		FXa_inhibition	445..480	CDD:291342
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11196
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24035
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910