DRSC/TRiP Functional Genomics Resources

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Protein Alignment drpr and STAB2

DIOPT Version :9

Sequence 1:NP_001261276.1 Gene:drpr / 38218 FlyBaseID:FBgn0027594 Length:1042 Species:Drosophila melanogaster
Sequence 2:NP_060034.9 Gene:STAB2 / 55576 HGNCID:18629 Length:2551 Species:Homo sapiens


Alignment Length:1854 Identity:319/1854 - (17%)
Similarity:443/1854 - (23%) Gaps:1023/1854 - (55%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLPVILIACLAQLVLAQADLKDLDGPNICKRRELYNVDVVYTELQSFQERGSTWCVTFPPRCSTY 65
            ||..::|.||..:|           .|.|...|           .:.|.|          ||...
Human     2 MLQHLVIFCLGLVV-----------QNFCSPAE-----------TTGQAR----------RCDRK 34

  Fly    66 RIKHRVVNKTKTIAKNRIVRDCCDGYI----ASAG--EC------------VPHCSEPCQHGRCI 112
            .:. .:..:.::.|.|..|: |.|||.    .|.|  :|            :|.|...|:.. .:
Human    35 SLL-TIRTECRSCALNLGVK-CPDGYTMITSGSVGVRDCRYTFEVRTYSLSLPGCRHICRKD-YL 96

  Fly   113 SPEKCKCDHGYGGPACDINCPPGWYGRNCSMQCDCLNNAVCEPFSGDCECAKGYTGARCADICPE 177
            .|   :|..|..||.| |.| ||..|..|:.:..|....   ..:|.|.|.:|:.|..|.....:
Human    97 QP---RCCPGRWGPDC-IEC-PGGAGSPCNGRGSCAEGM---EGNGTCSCQEGFGGTACETCADD 153

  Fly   178 GFFGANCSEKCRCENGGKCH---HVSGECQCAPGFTGPLCDMRCPDGKHGAQCQQDCP---CQND 236
            ..||.:||..|.|.: |.|:   ...|.|:|...:|||.||...|          :|.   |..:
Human   154 NLFGPSCSSVCNCVH-GVCNSGLDGDGTCECYSAYTGPKCDKPIP----------ECAALLCPEN 207

  Fly   237 GKCQPETG-----ACMCNPGWTGD--------VCANKCPVGSYGPGCQESCECYKGAPCHHITGQ 288
            .:|.|.|.     .|.|.|.:.||        .|..|.        |.....|....|..|   .
Human   208 SRCSPSTEDENKLECKCLPNYRGDGKYCDPINPCLRKI--------CHPHAHCTYLGPNRH---S 261

  Fly   289 CECPPGYRGER--CF--DECQLN------------------------------TYGFNCSMTCDC 319
            |.|..||||:.  |.  |.||:|                              ..|..||||..|
Human   262 CTCQEGYRGDGQVCLPVDPCQINFGNCPTKSTVCKYDGPGQSHCECKEHYQNFVPGVGCSMTDIC 326

  Fly   320 ANDAMCDR-ANGT--------CICNPGWTG------AKCAERICEAN-----KY----------- 353
            .:|..|.| ||.|        |||..|:.|      ....||:.|.|     |:           
Human   327 KSDNPCHRNANCTTVAPGRTECICQKGYVGDGLTCYGNIMERLRELNTEPRGKWQGRLTSFISLL 391

  Fly   354 -------------------------GLDCNR---------------------------------- 359
                                     |.:.|.                                  
Human   392 DKAYAWPLSKLGPFTVLLPTDKGLKGFNVNELLVDNKAAQYFVKLHIIAGQMNIEYMNNTDMFYT 456

  Fly   360 ------------------------------------------------------TCECD------ 364
                                                                  |.|.:      
Human   457 LTGKSGEIFNSDKDNQIKLKLHGGKKKVKIIQGDIIASNGLLHILDRAMDKLEPTFESNNEQTIM 521

  Fly   365 -------------MEHTDLCH----------------------------------PE-------- 374
                         :|.|:|.|                                  ||        
Human   522 TMLQPRYSKFRSLLEETNLGHALDEDGVGGPYTIFVPNNEALNNMKDGTLDYLLSPEGSRKLLEL 586

  Fly   375 ----------------------------------------------------------------- 374
                                                                             
Human   587 VRYHIVPFTQLEVATLISTPHIRSMANQLIQFNTTDNGQILANDVAMEEIEITAKNGRIYTLTGV 651

  Fly   375 ----------------------TGNC-QCS-IGWS-------------------------SAQCT 390
                                  .|.| .|| :.||                         .:.|.
Human   652 LIPPSIVPILPHRCDETKREMKLGTCVSCSLVYWSRCPANSEPTALFTHRCVYSGRFGSLKSGCA 716

  Fly   391 RPCT-----------FLRYGPNCE-----LTCNCKNGAKCSPV---NGTCLCAPGWRGPTCEESC 436
            |.|.           |  |||:|.     .:..|....:|:..   ||||:|..|::|..|:...
Human   717 RYCNATVKIPKCCKGF--YGPDCNQCPGGFSNPCSGNGQCADSLGGNGTCICEEGFQGSQCQFCS 779

  Fly   437 EPGTFGQDCALRCDCQNGAKCE---PETGQCL---CTAGWKNIKCDRPCDLNHFGQDCAK-VCDC 494
            :|..:|..|..:|.|.:|. |.   ...|.||   |..|.....||:....      |.. |..|
Human   780 DPNKYGPRCNKKCLCVHGT-CNNRIDSDGACLTGTCRDGSAGRLCDKQTSA------CGPYVQFC 837

  Fly   495 HNNAACNPQNG--SCTCAAGWTGE--RCER--KCDTGKFGHDCAQKCQCDFNNSLACDATNGRCV 553
            |.:|.|...||  ||.|.||:.|:  .|..  .| ||.....|::..:|     :........||
Human   838 HIHATCEYSNGTASCICKAGYEGDGTLCSEMDPC-TGLTPGGCSRNAEC-----IKTGTGTHTCV 896

  Fly   554 CKQDW------------------GGVH----C--------ETNCRSGYYGE--NCDKVCRCLNNS 586
            |:|.|                  ||.|    |        |..|:.|:.|.  :|:.:..||..:
Human   897 CQQGWTGNGRDCSEINNCLLPSAGGCHDNASCLYVGPGQNECECKKGFRGNGIDCEPITSCLEQT 961

  Fly   587 -SCDP-------DSG--NCICSAGWTGADCAEPCPPGF--YG---MECK---------------- 620
             .|.|       .||  :|:|..|:.|        .||  ||   :|..                
Human   962 GKCHPLASCQSTSSGVWSCVCQEGYEG--------DGFLCYGNAAVELSFLSEAAIFNRWINNAS 1018

  Fly   621 ----------------------------------------------------------------- 620
                                                                             
Human  1019 LQPTLSATSNLTVLVPSQQATEDMDQDEKSFWLSQSNIPALIKYHMLLGTYRVADLQTLSSSDML 1083

  Fly   621 -------------------------------------------------------------ERCP 624
                                                                         |:.|
Human  1084 ATSLQGNFLHLAKVDGNITIEGASIVDGDNAATNGVIHIINKVLVPQRRLTGSLPNLLMRLEQMP 1148

  Fly   625 E---------------------------------------------------------------- 625
            :                                                                
Human  1149 DYSIFRGYIIQYNLANAIEAADAYTVFAPNNNAIENYIREKKVLSLEEDVLRYHVVLEEKLLKND 1213

  Fly   626 -------------------------------------------ILHG--------NKSCDHITGE 639
                                                       ::||        ...||:....
Human  1214 LHNGMHRETMLGFSYFLSFFLHNDQLYVNEAPINYTNVATDKGVIHGLGKVLEIQKNRCDNNDTT 1278

  Fly   640 IL---CRTGYIGLTC---------------------------------------EHPCPAGLYGP 662
            |:   |||....|||                                       ...|.||.:||
Human  1279 IIRGRCRTCSSELTCPFGTKSLGNEKRRCIYTSYFMGRRTLFIGCQPKCVRTVITRECCAGFFGP 1343

  Fly   663 GCKLKCN------CEHGGEC---NHVTGQCQCLPGWTGSNCNESCPTDTYGQGCAQRCRCVHHKV 718
            .|: .|.      |...|.|   .:.||.|:|..|::|:.| |:|....||..|.|.|.|||.: 
Human  1344 QCQ-PCPGNAQNVCFGNGICLDGVNGTGVCECGEGFSGTAC-ETCTEGKYGIHCDQACSCVHGR- 1405

  Fly   719 CRK---ADGMCICETGWSGTRCDEVCPEGFYGEHCMNTC--------------ACP-SANFQ--- 762
            |.:   .||.|.|:.||.|..||....|    ::|..||              :|. :|.||   
Human  1406 CNQGPLGDGSCDCDVGWRGVHCDNATTE----DNCNGTCHTSANCLTNSDGTASCKCAAGFQGNG 1466

  Fly   763 --------CHAAHG-----------------CVCRSGYTGD---------------NCDELIASQ 787
                    |..::|                 |.|::|||||               .||:   :.
Human  1467 TICTAINACEISNGGCSAKADCKRTTPGRRVCTCKAGYTGDGIVCLEINPCLENHGGCDK---NA 1528

  Fly   788 RIADQSENSSRASV---------ALTLVLMTLF---ACIIFAVFIY------------------- 821
            .......|.:..:.         ..||:.:.|.   .|..||:..:                   
Human  1529 ECTQTGPNQAACNCLPAYTGDGKVCTLINVCLTKNGGCSEFAICNHTGQVERTCTCKPNYIGDGF 1593

  Fly   822 ------YRRRVSNLKTE----IAHVHYTHDTNPPS-----WPPNHNFDNPVYGMQAETRLLPNNM 871
                  |:....|.||.    ....|:..|...|.     .|.:..||.                
Human  1594 TCRGSIYQELPKNPKTSQYFFQLQEHFVKDLVGPGPFTVFAPLSAAFDE---------------- 1642

  Fly   872 RSKMNNFDQRSTMSTDYGDDCNASGRVGSYSINYNHDLLTKNL----NAD--RTNPIVYNESLKE 930
            .:::.::|:...|.           :|..|.:...|.||.:||    ||.  :..|||.  |:.:
Human  1643 EARVKDWDKYGLMP-----------QVLRYHVVACHQLLLENLKLISNATSLQGEPIVI--SVSQ 1694

  Fly   931 EHVYDEIKHKEGYKD------PVKIYSKILFPED 958
            ..||...|.|....|      .|.|..|:|.|::
Human  1695 STVYINNKAKIISSDIISTNGIVHIIDKLLSPKN 1728

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drprNP_001261276.1 EMI 27..92 CDD:284877 13/64 (20%)
EGF_CA 274..319 CDD:304395 19/78 (24%)
DSL <479..518 CDD:302925 14/43 (33%)
DSL <567..606 CDD:302925 14/50 (28%)
STAB2NP_060034.9 EGF_3 246..275 CDD:289699 10/31 (32%)
EGF_3 326..361 CDD:289699 12/34 (35%)
Fasciclin 382..505 CDD:280607 2/122 (2%)
Fasciclin 526..654 CDD:280607 6/127 (5%)
EGF_3 837..865 CDD:289699 12/27 (44%)
EGF_3 920..951 CDD:289699 8/30 (27%)
EGF_3 957..993 CDD:289699 12/43 (28%)
Fasciclin 1009..1129 CDD:280607 0/119 (0%)
Fasciclin 1148..1265 CDD:280607 3/116 (3%)
EGF_3 1437..1469 CDD:289699 6/31 (19%)
EGF_3 1475..1511 CDD:289699 9/35 (26%)
EGF_3 1517..1553 CDD:289699 3/38 (8%)
EGF_3 1559..1595 CDD:289699 4/35 (11%)
Fasciclin 1617..1726 CDD:280607 30/137 (22%)
Fasciclin 1752..1882 CDD:280607
EGF_3 2086..2121 CDD:289699
EGF_3 2127..2164 CDD:289699
Link_domain_TSG_6_like 2198..2290 CDD:239592
FAS1 2356..2449 CDD:214719
Interaction with TMSB4X. /evidence=ECO:0000269|PubMed:18519035 2504..2514
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2512..2551
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1218
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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