DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drpr and PDGFRB

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_002600.1	Gene:	PDGFRB / 5159	HGNCID:	8804	Length:	1106	Species:	Homo sapiens

Alignment Length:	110	Identity:	28/110 - (25%)
Similarity:	50/110 - (45%)	Gaps:	22/110 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   941 EGYKDPVKIYSKILFPEDEY---DHLDYSRPSTSQKPHYHRMNDAM--LNINQDEEKPSNVKNMT 1000
            ||||   |.|.::   ::|:   ||....| |.::.|.:|.:...:  .::.....:|:...|..
Human   964 EGYK---KKYQQV---DEEFLRSDHPAILR-SQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDY 1021

  Fly  1001 VLLNKPLPPTEPE-----PQHECFDNTNTNLDNVSTASPSS--SP 1038
            ::   |||..:||     |........::.|:.|:|:|..|  ||
Human  1022 II---PLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSP 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395
		DSL	<479..518	CDD:302925
		DSL	<567..606	CDD:302925
PDGFRB	NP_002600.1	ig	37..114	CDD:278476
		IG	40..110	CDD:214652
		IG_like	222..310	CDD:214653
		Ig1_PDGFR-alphabeta	228..312	CDD:143269
		Ig4_PDGFR-alpha	314..415	CDD:143267
		Ig	425..523	CDD:299845
		PTKc_PDGFR_beta	562..953	CDD:133238
		Pkinase_Tyr	600..953	CDD:285015
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1019..1106		14/48 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900