DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drpr and Dkk4

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_001102802.1	Gene:	Dkk4 / 502097	RGDID:	1563172	Length:	221	Species:	Rattus norvegicus

Alignment Length:	224	Identity:	55/224 - (24%)
Similarity:	80/224 - (35%)	Gaps:	58/224 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   489 AKVCDCHNNAACNPQNGSCTCAAGWTGERC--ERKCDTGKFG---HD----CA------QKCQCD 538
            |.|.|.:|..:.:...||      ..|.:|  ::.|:.|||.   ||    ||      ::||
  Rat    18 ALVLDFNNIKSSSDVQGS------GKGSQCVSDKDCNVGKFCFALHDERSFCATCRRVRRRCQ-- 74

  Fly   539 FNNSLACDAT---NGRCVCKQDWGGV-HCETNCRSGYYGENCDKVCRCLNNSSCDPDSGNCICSA 599
             .:::.|..|   |..|...::...| ...|:.:.|.|.|...|.....|.....|.:.....:.
  Rat    75 -RSAMCCPGTVCVNDVCTAVENTRPVMDRNTDGQDGTYAEGTTKWPAEENRPQGKPSTKKSQSNK 138

  Fly   600 GWTGADC--AEPCPPG------FYGMECKERCPEILHGNKSCDHITGEILCRTGYIGLTCEHPCP 656
            |..|..|  ...|.||      |:...||   |.:|.         |::..|.|       |...
  Rat   139 GQEGESCLRTSDCGPGLCCARHFWTKICK---PVLLE---------GQVCSRRG-------HKDT 184

  Fly   657 AGLYGPGCKLKCNCEHGGEC-NHVTGQCQ 684
            |  ..|....:|:|..|..| :.|||..|
  Rat   185 A--QAPEIFQRCDCGPGLSCRSQVTGNRQ 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395
		DSL	<479..518	CDD:302925	7/28 (25%)
		DSL	<567..606	CDD:302925	8/38 (21%)
Dkk4	NP_001102802.1	Dickkopf_N	41..91	CDD:282549	14/52 (27%)
Dkk4	NP_001102802.1	Prokineticin	<145..202	CDD:148298	18/77 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900