Protein Alignment drpr and LAMB1

DIOPT Version :10

• Sequence 1: NP_001261276.1
• Gene: drpr / 38218
• FlyBaseID: FBgn0027594
• Length: 1042
• Species: Drosophila melanogaster
• Sequence 2: XP_054214165.1
• Gene: LAMB1 / 3912
• HGNCID: 6486
• Length: 1810
• Species: Homo sapiens
• Alignment Length: 1228
• Identity: 275/1228 - (22%)
• Similarity: 385/1228 - (31%)
• Gaps: 471/1228 - (38%)

  Fly    83 IVRDCCDGYIASAGECVP--------------HCSEPCQH-----------------------GR 110
            :||..|..| ..|.||.|              ||.  |:|                       ||
Human   290 VVRGNCFCY-GHASECAPVDGFNEEVEGMVHGHCM--CRHNTKGLNCELCMDFYHDLPWRPAEGR 351

  Fly   111 ----CISPEKCKCDH----------------GYGGPACDINCPPGWYGRNCSM------------ 143
                |   :||.|:.                ...|..|| :|.....||||..
Human   352 NSNAC---KKCNCNEHSISCHFDMAVYLATGNVSGGVCD-DCQHNTMGRNCEQCKPFYYQHPERD 412

  Fly   144 --------QCDC-----LNNAVCEPF--------SGDCECAKGYTGARCADICPEGFFGANCSE- 186
                    :|.|     .|..:|:.:        :|.|.|.....|..| |:|.|||:..:..:
Human   413 IRDPNFCERCTCDPAGSQNEGICDSYTDFSTGLIAGQCRCKLNVEGEHC-DVCKEGFYDLSSEDP 476

  Fly   187 ----KCRCE------NGGKCHHVSGECQCAPGFTGPLCDMRCP---------DGKHGAQCQQDCP 232
                .|.|.      .|..|...:|.|.|....||..||...|         ||     | :.|.
Human   477 FGCKSCACNPLGTIPGGNPCDSETGHCYCKRLVTGQHCDQCLPEHWGLSNDLDG-----C-RPCD 535

  Fly   233 CQNDG----KCQPETGACMCNPGWTGDVCANKCPVGSY----------------GPG-------- 269
            |...|    .|..|:|.|.|.|...|..| |:...|.|                |||
Human   536 CDLGGALNNSCFAESGQCSCRPHMIGRQC-NEVEPGYYFATLDHYLYEAEEANLGPGVSIVERQY 599

  Fly   270 CQESCECYKGA----------------------------------PCH------------HITGQ 288
            .|:....:.||                                  |.|            .|...
Human   600 IQDRIPSWTGAGFVRVPEGAYLEFFIDNIPYSMEYDILIRYEPQLPDHWEKAVITVQRPGRIPTS 664

  Fly   289 CEC--------------PPGYR-----GERCFDECQLNTYGFNCSMTCDCANDAMCDR------- 327
            ..|              .||.|     ...||::      |.|.::..:.......|.
Human   665 SRCGNTIPDDDNQVVSLSPGSRYVVLPRPVCFEK------GTNYTVRLELPQYTSSDSDVESPYT 723

  Fly   328 ---------------------ANGTCICNPGW---TGAKCAER-----------ICE-------- 349
                                 :....:.|..|   ...:|.|.           :|.
Human   724 LIDSLVLMPYCKSLDIFTVGGSGDGVVTNSAWETFQRYRCLENSRSVVKTPMTDVCRNIIFSISA 788

  Fly   350 -ANKYGLDCNRTCECDMEH--TDLCHPETGNCQCSIGWSSAQCTR--PCTFLRYGPNCELTCNC- 408
             .::.||    .||||.:.  :.:|.|..|.|||........|.|  |.|| .:||:....|.|
Human   789 LLHQTGL----ACECDPQGSLSSVCDPNGGQCQCRPNVVGRTCNRCAPGTF-GFGPSGCKPCECH 848

  Fly   409 ---KNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQNGA-KCEPETGQCL-CTA 468
               ...|.|:||.|.|.|..|.....|:. |.||.:|......|.|...| .|:|.||:|| |..
Human   849 LQGSVNAFCNPVTGQCHCFQGVYARQCDR-CLPGHWGFPSCQPCQCNGHADDCDPVTGECLNCQD 912

  Fly   469 GWKNIKCDRPCDLNHFGQ------DCAKVCDCHNNAACNPQNG----------------SCTCAA 511
            ......|:| |...::|.      |..:.|.|.:    .|.:|                :|.|..
Human   913 YTMGHNCER-CLAGYYGDPIIGSGDHCRPCPCPD----GPDSGRQFARSCYQDPVTLQLACVCDP 972

  Fly   512 GWTGERCERKCDTGKFGH------DCAQKCQC----DFNNSLACDATNGRCV-CKQDWGGVHCET 565
            |:.|.||: .|.:|.||:      .| |.|||    |..:..|||...|||: |.....|.||:.
Human   973 GYIGSRCD-DCASGYFGNPSEVGGSC-QPCQCHNNIDTTDPEACDKETGRCLKCLYHTEGEHCQF 1035

  Fly   566 NCRSGYYGENCDKVCRCLNNSSCDPDSGNCICSAGWT------GADCAEPCPPGFYGMECKERCP 624
             ||.||||:...:.||            .|:|:...|      |:||
Human  1036 -CRFGYYGDALRQDCR------------KCVCNYLGTVQEHCNGSDC------------------ 1069

  Fly   625 EILHGNKSCDHITGEILCRTGYIGLTCEHPCPAGLY----GPGCKLKCNC----EHGGECNHVTG 681
                   .||..||:.||....||..|:. |....:    |.||. .|||    ..|..||..||
Human  1070 -------QCDKATGQCLCLPNVIGQNCDR-CAPNTWQLASGTGCD-PCNCNAAHSFGPSCNEFTG 1125

  Fly   682 QCQCLPGWTGSNCNESCPTDTYGQ---GCAQRCRC----VHHKVCRKADGMCICETGWSGTRCDE 739
            ||||:||:.|..|:| |....:|.   .| :.|.|    :....|.::.|.|:|..|..|.|||:
Human  1126 QCQCMPGFGGRTCSE-CQELFWGDPDVEC-RACDCDPRGIETPQCDQSTGQCVCVEGVEGPRCDK 1188

  Fly   740 VCPEGFYGEHCMNTCACPSANFQCHAAHGCVCRSGYTGDNCDELIASQRIADQSENSSRASVALT 804
             |..|:.|       ..|    .|...|.|...       .|.:||  .:.:::......:.||.
Human  1189 -CTRGYSG-------VFP----DCTPCHQCFAL-------WDVIIA--ELTNRTHRFLEKAKALK 1232

  Fly   805 LVLMTLFACIIFAVFIYYR-------RRVSNLKTEIAHVHYTHDTNPPSWPPNHNFDN------- 855
                      |..|...||       |:||.:|..:|        ..|:..|..|..|
Human  1233 ----------ISGVIGPYRETVDSVERKVSEIKDILA--------QSPAAEPLKNIGNLFEEAEK 1279

  Fly   856 ---PVYGMQAETRLLPNNMRSKMNN----FDQRSTMS-------------TDYGDDCNASGRVGS 900
               .|..|.|:..:..::..|:.|:    .|...|.:             .::..:.:..|.:.|
Human  1280 LIKDVTEMMAQVEVKLSDTTSQSNSTAKELDSLQTEAESLDNTVKELAEQLEFIKNSDIRGALDS 1344

  Fly   901 YSINYNHDL-LTKNLNADRTNP--IVYNESLKEEHVYDEIKHKEG-YKDPVKIYSKIL 954
            .:..:...| ..:.:||..|.|  .|...:|..:.|.|.:..:|. :|:..:..:::|
Human  1345 ITKYFQMSLEAEERVNASTTEPNSTVEQSALMRDRVEDVMMERESQFKEKQEEQARLL 1402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	26..92	CDD:462204	3/8 (38%)
		EGF_CA	274..319	CDD:473889	13/109 (12%)
		gliding_CglD	<451..579	CDD:468178	50/162 (31%)
		DSL	567..609	CDD:473190	14/47 (30%)
LAMB1	XP_054214165.1	Laminin_N	59..293	CDD:459653	1/2 (50%)
		EGF_Lam	295..347	CDD:238012	10/54 (19%)
		EGF_Lam	359..411	CDD:238012	10/52 (19%)
		Laminin_EGF	422..479	CDD:395007	14/57 (25%)
		Laminin_EGF	482..536	CDD:395007	16/59 (27%)
		EGF_Lam	533..>572	CDD:238012	13/39 (33%)
		EGF_Lam	797..842	CDD:214543	17/45 (38%)
		Laminin_EGF	845..893	CDD:395007	16/48 (33%)
		Laminin_EGF	891..938	CDD:395007	15/47 (32%)
		Laminin_EGF	941..997	CDD:395007	14/60 (23%)
		Laminin_EGF	1000..1044	CDD:395007	20/44 (45%)
		Laminin_EGF	1052..1106	CDD:395007	18/79 (23%)
		Laminin_EGF	1108..1156	CDD:395007	20/49 (41%)
		Laminin_EGF	1156..>1195	CDD:395007	13/39 (33%)
		PTZ00121	<1248..1802	CDD:173412	30/163 (18%)
		cc_LAMB1_C	1738..1810	CDD:411971