Protein Alignment drpr and PEAR1

DIOPT Version :9

• Sequence 1: NP_001261276.1
• Gene: drpr / 38218
• FlyBaseID: FBgn0027594
• Length: 1042
• Species: Drosophila melanogaster
• Sequence 2: XP_016856723.1
• Gene: PEAR1 / 375033
• HGNCID: 33631
• Length: 1125
• Species: Homo sapiens
• Alignment Length: 1055
• Identity: 346/1055 - (32%)
• Similarity: 474/1055 - (44%)
• Gaps: 176/1055 - (16%)

  Fly    65 YRIKHRVVNKTKTIAKNRIVRDCCDGYIASAGECVPHCSEPCQHGRCISPEKCKCDHGYGGPACD 129
            ||..:|.|  .||..:.|:  .||.|:..|.|.|||.|::.|.||||::|.:|:|..|:.|..|.
Human   160 YRTVYRQV--VKTDHRQRL--QCCHGFYESRGFCVPLCAQECVHGRCVAPNQCQCVPGWRGDDCS 220

  Fly   130 INCPPGWYGRNCSMQCDCLNNAVCEPFSGDCECAKGYTGARCADICPEGFFGANCSEKCRCENGG 194
            ..|.||.:|..|...|.|.||:.|:|.||.|.|..|.....|...|..|::|..|..:|:| :|.
Human   221 SECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQC-HGA 284

  Fly   195 KCHHVSGECQCAPGFTGPLCDMRCPDGKHGAQCQQDCPCQNDGKCQPETGACMCNPGWTGDVCAN 259
            .|...:|.|.|....|||.||:.|..|..|..|.....|||.|..|...|:|.|.|||.|.:|:.
Human   285 PCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSL 349

  Fly   260 KCPVGSYGPGCQESCECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCDCANDAM 324
            .||.|.:||.|.:.|.|:.|..|...||||.|.|||.|:||.:||.:..:|.:|:.|||||.||.
Human   350 PCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDAR 414

  Fly   325 CDRANGTCICNPGWTGAKCAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSAQC 389
            |..|||.|:|..|:||.:|.:|:|....|||.|...|.||.||:..|||..|.|.|..||:...|
Human   415 CFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHC 479

  Fly   390 TRPCTFLRYGPNCELTCNCKNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQNG 454
            ...|....:||.|:..|.|.:|..|...:|.|.||||:.||.|...|.|.|:|.:|:.||.|:|.
Human   480 NESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENA 544

  Fly   455 AKCEPETGQCLCTAGWKNIKCDRPCDLNHFGQDCAKVCDCHNNAACNPQNGSCTCAAGWTGERCE 519
            ..|.|..|:|:|..||:...|..||....:|..|...|.|.:.|.|:||.|:|||..||.|..|:
Human   545 IACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQ 609

  Fly   520 RKCDTGKFGHDCAQKCQCDFNNSLACDATNGRCVCKQDWGGVHCETNCRSGYYGENCDKVCRCLN 584
            ..|..|:||..||.:|.||  :|..||..:|||.|:..|.|..|..:|..|.:|.||...|.|.|
Human   610 LPCPKGQFGEGCASRCDCD--HSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKN 672

  Fly   585 NSSCDPDSGNCICSAGWTGADCAEPCPPGFYGMECKERCPEILHGNKSCDHITGEILCRTGYIGL 649
            ..:|.|::|||:|:.|:.|..|...|.||.||..|
Human   673 GGTCLPENGNCVCAPGFRGPSCQRSCQPGRYGKRC------------------------------ 707

  Fly   650 TCEHPCPAGLYGPGCKLKCNCEHGGECNHVTGQCQCLPGWTGSNCNESCPTDTYGQGCAQRCRCV 714
                            :.|.|.:...|:...|.|.||.||||.:|::.||...:|:.|||.|:|.
Human   708 ----------------VPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCH 756

  Fly   715 HHKVCRKADGMCICETGWSGTRCDEVCPEGFYGEHCMNTCACPSANFQCHAAHG-CVCRSGYTGD 778
            |...|...||.|||..||:|..|.|.||.|.:|.:|...|.|.... :||...| |||..|::|.
Human   757 HGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGE-KCHPETGACVCPPGHSGA 820

  Fly   779 NCDELIASQRIADQ-----------SENSSRASVALTLVLMTLFACIIFAVFIYYRR-------- 824
            .|       ||..|           :.||..|.:.:. ||.:|...:: |:||.||.
Human   821 PC-------RIGIQEPFTVMPTTPVAYNSLGAVIGIA-VLGSLVVALV-ALFIGYRHWQKGKEHH 876

  Fly   825 --RVSNLKTEIAHVHYTHDTNPPSWPPNHNFDNPVYGMQAE-------TRLLPNNMRSKMNN--- 877
              .|:.....:....|.....|||:  :|.:.||.|...::       ...:|..:.:.:.|
Human   877 HLAVAYSSGRLDGSEYVMPDVPPSY--SHYYSNPSYHTLSQCSPNPPPPNKVPGPLFASLQNPER 939

  Fly   878 ------FDQRSTMSTDY--------GDDCNASGRVG---SYSIN------YNHDLLT-KNLNADR 918
                  .|..:|:..|:        |.....|.|:.   |||.:      ||..|:: :.|.|..
Human   940 PGGAQGHDNHTTLPADWKHRREPPPGPLDRGSSRLDRSYSYSYSNGPGPFYNKGLISEEELGASV 1004

  Fly   919 TNPIVYNESLKEEHVYDEIK---------HKEGY------------KDPVKIY--SKILFPEDEY 960
            .       ||..|:.|..|:         .:..|            :.|.:.:  .:...|:.:.
Human  1005 A-------SLSSENPYATIRDLPSLPGGPRESSYMEMKGPPSGSPPRQPPQFWDSQRRRQPQPQR 1062

  Fly   961 DHLDYSRPSTSQKPHYHRMNDAMLNINQDEEKPSNVKNMTVLLNKPLPPTEPEPQHECFDNTNT- 1024
            |...|.:||    |..|           |.:        :|....||||..|...::...|::.
Human  1063 DSGTYEQPS----PLIH-----------DRD--------SVGSQPPLPPGLPPGHYDSPKNSHIP 1104

  Fly  1025 -NLDNVSTASPSSSP 1038
             :.|......|.|.|
Human  1105 GHYDLPPVRHPPSPP 1119

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877	10/26 (38%)
		EGF_CA	274..319	CDD:304395	21/44 (48%)
		DSL	<479..518	CDD:302925	16/38 (42%)
		DSL	<567..606	CDD:302925	16/38 (42%)
PEAR1	XP_016856723.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	119	1.000	Domainoid score	I5794
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47996
OrthoDB	1	1.010	-	-		D34806at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40878
orthoMCL	1	0.900	-	-		OOG6_102891
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1195
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.690