Protein Alignment drpr and PEAR1

DIOPT Version :10

• Sequence 1: NP_001261276.1
• Gene: drpr / 38218
• FlyBaseID: FBgn0027594
• Length: 1042
• Species: Drosophila melanogaster
• Sequence 2: XP_016856723.1
• Gene: PEAR1 / 375033
• HGNCID: 33631
• Length: 1125
• Species: Homo sapiens
• Alignment Length: 1059
• Identity: 345/1059 - (32%)
• Similarity: 473/1059 - (44%)
• Gaps: 184/1059 - (17%)

  Fly    65 YRIKHRVVNKTKTIAKNRIVRDCCDGYIASAGECVPHCSEPCQHGRCISPEKCKCDHGYGGPACD 129
            ||..:|.|  .||..:.|:  .||.|:..|.|.|||.|::.|.||||::|.:|:|..|:.|..|.
Human   160 YRTVYRQV--VKTDHRQRL--QCCHGFYESRGFCVPLCAQECVHGRCVAPNQCQCVPGWRGDDCS 220

  Fly   130 INCPPGWYGRNCSMQCDCLNNAVCEPFSGDCECAKGYTGARCADICPEGFFGANCSEKCRCENGG 194
            ..|.||.:|..|...|.|.||:.|:|.||.|.|..|.....|...|..|::|..|..:|:| :|.
Human   221 SECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQC-HGA 284

  Fly   195 KCHHVSGECQCAPGFTGPLCDMRCPDGKHGAQCQQDCPCQNDGKCQPETGACMCNPGWTGDVCAN 259
            .|...:|.|.|....|||.||:.|..|..|..|.....|||.|..|...|:|.|.|||.|.:|:.
Human   285 PCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSL 349

  Fly   260 KCPVGSYGPGCQESCECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCDCANDAM 324
            .||.|.:||.|.:.|.|:.|..|...||||.|.|||.|:||.:||.:..:|.:|:.|||||.||.
Human   350 PCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDAR 414

  Fly   325 CDRANGTCICNPGWTGAKCAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSAQC 389
            |..|||.|:|..|:||.:|.:|:|....|||.|...|.||.||:..|||..|.|.|..||:...|
Human   415 CFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHC 479

  Fly   390 TRPCTFLRYGPNCELTCNCKNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQNG 454
            ...|....:||.|:..|.|.:|..|...:|.|.||||:.||.|...|.|.|:|.:|:.||.|:|.
Human   480 NESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENA 544

  Fly   455 AKCEPETGQCLCTAGWKNIKCDRPCDLNHFGQDCAKVCDCHNNAACNPQNGSCTCAAGWTGERCE 519
            ..|.|..|:|:|..||:...|..||....:|..|...|.|.:.|.|:||.|:|||..||.|..|:
Human   545 IACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQ 609

  Fly   520 RKCDTGKFGHDCAQKCQCDFNNSLACDATNGRCVCKQDWGGVHCETNCRSGYYGENCDKVCRCLN 584
            ..|..|:||..||.:|.||  :|..||..:|||.|:..|.|..|..:|..|.:|.||...|.|.|
Human   610 LPCPKGQFGEGCASRCDCD--HSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKN 672

  Fly   585 NSSCDPDSGNCICSAGWTGADCAEPCPPGFYGMECKERCPEILHGNKSCDHITGEILCRTGYIGL 649
            ..:|.|::|||:|:.|:.|..|...|.||.||..|
Human   673 GGTCLPENGNCVCAPGFRGPSCQRSCQPGRYGKRC------------------------------ 707

  Fly   650 TCEHPCPAGLYGPGCKLKCNCEHGGECNHVTGQCQCLPGWTGSNCNESCPTDTYGQGCAQRCRCV 714
                            :.|.|.:...|:...|.|.||.||||.:|::.||...:|:.|||.|:|.
Human   708 ----------------VPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCH 756

  Fly   715 HHKVCRKADGMCICETGWSGTRCDEVCPEGFYGEHCMNTCACPSANFQCHAAHG-CVCRSGYTGD 778
            |...|...||.|||..||:|..|.|.||.|.:|.:|...|.|.... :||...| |||..|::|.
Human   757 HGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGE-KCHPETGACVCPPGHSGA 820

  Fly   779 NCDELIASQRIADQ-----------SENSSRASVALTLVLMTLFACIIFAVFIYYRR-------- 824
            .|       ||..|           :.||..|.:.:. ||.:|...:: |:||.||.
Human   821 PC-------RIGIQEPFTVMPTTPVAYNSLGAVIGIA-VLGSLVVALV-ALFIGYRHWQKGKEHH 876

  Fly   825 --RVSNLKTEIAHVHYTHDTNPPSWPPNHNFDNPVYGMQAE-------TRLLPNNMRSKMNN--- 877
              .|:.....:....|.....|||:  :|.:.||.|...::       ...:|..:.:.:.|
Human   877 HLAVAYSSGRLDGSEYVMPDVPPSY--SHYYSNPSYHTLSQCSPNPPPPNKVPGPLFASLQNPER 939

  Fly   878 ------FDQRSTMSTDY--------GDDCNASGRVG-SYSINYNHDLLTKNLNADRTNPIVYNE- 926
                  .|..:|:..|:        |.....|.|:. |||.:|::.          ..|. ||:
Human   940 PGGAQGHDNHTTLPADWKHRREPPPGPLDRGSSRLDRSYSYSYSNG----------PGPF-YNKG 993

  Fly   927 ------------SLKEEHVYDEIK---------HKEGY------------KDPVKIY--SKILFP 956
                        ||..|:.|..|:         .:..|            :.|.:.:  .:...|
Human   994 LISEEELGASVASLSSENPYATIRDLPSLPGGPRESSYMEMKGPPSGSPPRQPPQFWDSQRRRQP 1058

  Fly   957 EDEYDHLDYSRPSTSQKPHYHRMNDAMLNINQDEEKPSNVKNMTVLLNKPLPPTEPEPQHECFDN 1021
            :.:.|...|.:||    |..|           |.:        :|....||||..|...::...|
Human  1059 QPQRDSGTYEQPS----PLIH-----------DRD--------SVGSQPPLPPGLPPGHYDSPKN 1100

  Fly  1022 TNT--NLDNVSTASPSSSP 1038
            ::.  :.|......|.|.|
Human  1101 SHIPGHYDLPPVRHPPSPP 1119

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	26..92	CDD:462204	10/26 (38%)
		EGF_CA	274..319	CDD:473889	21/44 (48%)
		gliding_CglD	<451..579	CDD:468178	52/127 (41%)
		DSL	567..609	CDD:473190	17/41 (41%)
PEAR1	XP_016856723.1	None