DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drpr and Dkk2

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_001099942.1	Gene:	Dkk2 / 295445	RGDID:	1308639	Length:	259	Species:	Rattus norvegicus

Alignment Length:	266	Identity:	61/266 - (22%)
Similarity:	84/266 - (31%)	Gaps:	103/266 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 KHGAQCQQDCPCQNDGKCQ-------PETG--ACMCNPGWTGDVCANKCPVGSYGPGCQESCECY 277
            |.|....|..||.:|.:|:       |..|  |||        ||..|          ::.|
  Rat    67 KKGKSLGQAYPCSSDKECEVGRYCHSPHQGSSACM--------VCRRK----------KKRC--- 110

  Fly   278 KGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCDCANDAMCDRANGTCICNPGWTGAK 342
                  |..|.| ||    |.||                           .||.||        .
  Rat   111 ------HRDGMC-CP----GTRC---------------------------NNGICI--------P 129

  Fly   343 CAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSAQCTRPCTFLRY-----GPNC 402
            ..|.|...:...||..|       |.|..|....|  ..:||.:  ..||.:.:.:     |..|
  Rat   130 VTESILTPHIPALDGTR-------HRDRNHGHYSN--HDLGWQN--LGRPHSKMPHIKGHEGDPC 183

  Fly   403 ELTCNCKNGAKCSPVNGTCLCAPG-WRGPTCEESCEPGTFGQDCALRCDCQNGAKCEPETGQCLC 466
            ..:.:|.:|..|:....|.:|.|. .:|..|.:..:.|:.|.:...||||..|..|:.
  Rat   184 LRSSDCIDGFCCARHFWTKICKPVLHQGEVCTKQRKKGSHGLEIFQRCDCAKGLSCKV------- 241

  Fly   467 TAGWKN 472
               ||:
  Rat   242 ---WKD 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395	9/44 (20%)
		DSL	<479..518	CDD:302925
		DSL	<567..606	CDD:302925
Dkk2	NP_001099942.1	Dickkopf_N	78..128	CDD:398399	22/108 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900