DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drpr and Megf10

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_001094127.1	Gene:	Megf10 / 291445	RGDID:	735084	Length:	1145	Species:	Rattus norvegicus

Alignment Length:	1143	Identity:	399/1143 - (34%)
Similarity:	545/1143 - (47%)	Gaps:	138/1143 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LIACLAQLVLAQADLKDLDGPNICKRRELYNVDVVYTELQSFQERGSTWCVTFPP--RCSTYRIK 68
            ||..|....|..|...:|:.||:|...|.|:|.|..:....|.:...|.|.....  :|:.:|:.
  Rat    11 LICSLLCHWLRAASSLNLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSCTDILNWFKCTRHRVS 75

  Fly    69 HRVVNK--TKTIAKNRIVRDCCDGYIASAGECVPHCSEPCQHGRCISPEKCKCDHGYGGPACDIN 131
            :|...:  .||:.:.:  ..||.|:..|...|||||::.|.|||||:|..|:|:.|:||..|...
  Rat    76 YRTAYRHGEKTMYRRK--SQCCPGFYESRDVCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSA 138

  Fly   132 CPPGWYGRNCSMQCDCLNNAVCEPFSGDCECAKGYTGARCADICPEGFFGANCSEKCRCENGGKC 196
            |....:|.:||.:|.|.|.|:|.|.:|.|.||.||.|.||.|.|.:|.:|.:|.::|:|:||..|
  Rat   139 CDGDHWGPHCSSRCQCKNRALCNPITGACHCAAGYRGWRCEDRCEQGTYGNDCHQRCQCQNGATC 203

  Fly   197 HHVSGECQCAPGFTGPLCDMRCPDGKHGAQCQQDCPCQNDGKCQPETGACMCNPGWTGDVCANKC 261
            .|::|||:|:||:||..|:..||.||||.||:|.|||||.|.|...||.|.|..||.|.||...|
  Rat   204 DHITGECRCSPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPC 268

  Fly   262 PVGSYGPGCQESCECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCDCANDAMCD 326
            |.|.:|..|.:.|:|:.|..|...||||.|.|||.||||.|||.:.|||..|:.||.|.|...|.
  Rat   269 PEGRFGKNCSQECQCHNGGACDAATGQCHCSPGYTGERCQDECPVGTYGVRCAETCRCVNGGKCY 333

  Fly   327 RANGTCICNPGWTGAKCAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSAQCTR 391
            ..:|||:|..|::|..|..|:|....||:.|::.|.|.:::|..|||.:|.|.|..|||...|..
  Rat   334 HVSGTCLCEAGFSGEFCEARLCPEGLYGIKCDKRCPCHLDNTHSCHPMSGECGCKPGWSGLYCNE 398

  Fly   392 PCTFLRYGPNCELTCNCKNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQNGAK 456
            .|:...||..|:..|:|:|||.|..|:|.|.||||::|..|...|..|.:|.:|:.||.|:|.|.
  Rat   399 TCSPGFYGEACQQICSCQNGADCDSVSGRCACAPGFKGTDCSTPCPLGRYGINCSSRCGCKNDAV 463

  Fly   457 CEPETGQCLCTAGWKNIKCDRPCDLNHFGQDCAKVCDCHNNAACNPQNGSCTCAAGWTGERCERK 521
            |.|..|.|:|.|||..:.|...|....:|..|...|.|.|..|||..:|:||||.||.||:||..
  Rat   464 CSPVDGSCICKAGWHGVDCSISCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCEFP 528

  Fly   522 CDTGKFGHDCAQKCQCDFNNSLACDATNGRCVCKQDWGGVHCETNCRSGYYGENCDKVCRCLNNS 586
            |..|.:|.:||::|.|  :::..|..|.|.|.|...|.||||::.|..|.:|.||...|.|.|.:
  Rat   529 CQDGTYGLNCAERCDC--SHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGA 591

  Fly   587 SCDPDSGNCICSAGWTGADCAEPCPPGFYGMECKERCPEILHGNKSCDHITGEILCRTGYIGLTC 651
            ||.||.|.|.|:.|:.|..|...|.|||||..|.:.||:.:|.:..|.||||...|..|:.|..|
  Rat   592 SCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALC 656

  Fly   652 EHPCPAGLYGPGCKLKCNCEHGGECNHVTGQCQCLPGWTGSNCNESCPTDTYGQGCAQRCRCVHH 716
            ...||:|.:|..|...|.|.:.|.||.:...|||.|||.||:|::.||...:|..|...|.|.:.
  Rat   657 NEVCPSGRFGKNCAGVCTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNG 721

  Fly   717 KVCRKADGMCICETGWSGTRCDEVCPEGFYGEHCMNTCACPSANFQCHAAHGCVCRSGYTGDNCD 781
            ..|...||.|.|..||:|..|.:.||.||||:.|...|.|.:.....|.:..|.||:|:.|.:|:
  Rat   722 AFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALVCQCQNGADCDHISGQCTCRTGFMGRHCE 786

  Fly   782 ELIAS-------QRIADQSENS----------------------------------SRASVALT- 804
            :...:       ::|.|...||                                  ||.|.||.
  Rat   787 QKCPAGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLNSLSRTSTALPA 851

  Fly   805 ----------LVLMTLFACIIFAVFIYYRRRVSNLKTEIAHVHYT------------HDTNPPSW 847
                      :|::.|....:.|:|:.||.:....::.:..|.||            .:|.|.|.
  Rat   852 DSYQIGAIAGIVVLLLVVLFLLALFVIYRHKQKRKESSMPAVTYTPAMRVINADYTIAETLPHSN 916

  Fly   848 PPN---HNFDNPVYGMQAETRLLPN-NMRSKM------NN-----------------FDQRSTMS 885
            ..|   |.|.||.|...::....|: |.|.:|      ||                 .|...|:.
  Rat   917 GGNANSHYFTNPSYHTLSQCAASPHVNNRDRMTIAKSKNNQLFVNLKNVNPGKRGALVDCTGTLP 981

  Fly   886 TDY--GDDCNASGRVGSYSINYNHDLLTKNLNADRTNPIVYNESL----KEEHVYDEIKHKEGYK 944
            .|:  |...|..|..|     .:...:.|:|. |......||.|.    ..|:.|..|      |
  Rat   982 ADWKQGGYLNELGAFG-----LDRSYMGKSLK-DLGKNSEYNSSTCSLSSSENPYATI------K 1034

  Fly   945 DPVKIYSKILFPEDEYDHLDYSRPSTSQKPHYHRMNDAMLNINQDEEKPSNVKNMTVLLNK---- 1005
            ||..:..|    ..|..:::...|:....|:....|....|.|..|.:|:......|..|.
  Rat  1035 DPPALLPK----SSECGYVEMKSPARRDSPYAEINNSTSANRNVYEVEPTVSVVQGVFSNNGHVT 1095

  Fly  1006 ----PLPPTEPEPQHECFDNTNTNLDNVSTASPSSSPK 1039
                .||.....|.|         .|.:.....|||||
  Rat  1096 QDPYDLPKNSHIPCH---------YDLLPVRDSSSSPK 1124

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877	17/68 (25%)
		EGF_CA	274..319	CDD:304395	25/44 (57%)
		DSL	<479..518	CDD:302925	18/38 (47%)
		DSL	<567..606	CDD:302925	17/38 (45%)
Megf10	NP_001094127.1	EMI	32..99	CDD:400092	17/68 (25%)
		EGF_Lam	281..318	CDD:214543	21/36 (58%)
		EGF_CA	542..587	CDD:419698	18/46 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I5986
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	798	1.000	Inparanoid score	I480
OMA	1	1.010	-	-		QHG47996
OrthoDB	1	1.010	-	-		D34806at33208
OrthoFinder	1	1.000	-	-		FOG0001631
OrthoInspector	1	1.000	-	-		otm45018
orthoMCL	1	0.900	-	-		OOG6_102891
Panther	1	1.100	-	-	O	PTHR24035
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1195
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840