DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drpr and CRB2

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_775960.4	Gene:	CRB2 / 286204	HGNCID:	18688	Length:	1285	Species:	Homo sapiens

Alignment Length:	1236	Identity:	239/1236 - (19%)
Similarity:	326/1236 - (26%)	Gaps:	614/1236 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 CCDGYIASAGE-----CVPH-----CSEPCQHGRCISPE-------KCKCDHGYGGPACDI---- 130
            |..|....|.|     |.|.     .::||.||....|:       :|.|..|:.||.|::
Human    47 CAPGTECQATESGGYTCGPMEPRGCATQPCHHGALCVPQGPDPTGFRCYCVPGFQGPRCELDIDE 111

  Fly   131 ---------------------NCPPGWYGRNCSMQCD------CLNNAVCEPFSGD--CECAKGY 166
                                 :||.|:.|..|.|:.|      ||:...|....|.  |.||.||
Human   112 CASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECASAPCLHGGSCLDGVGSFRCVCAPGY 176

  Fly   167 TGARC-ADICPEGFFGANCSEKCR---CENGGKCHH-VSG-ECQCA-PGFTGPLCDMRCPDGKHG 224
            .|.|| .|:           ::|:   |.:||.||. |:| .|.|| .|:.|..|:      :..
Human   177 GGTRCQLDL-----------DECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCE------REV 224

  Fly   225 AQCQQDCPCQNDGKCQPETGA--CMCNPGWTGDVC---ANKCPVGSYGPGCQESCEC-------- 276
            .:| ...||:::..|....|:  |:|.||::|::|   .::|   :..| ||....|
Human   225 LEC-ASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDEC---ASSP-CQHGGRCLQRSDPAL 284

  Fly   277 YKGAPC--------HHITG-QCECPPGYRGERC---FDECQLNTYGFNCSMTCDCANDAMC-DRA 328
            |.|...        .|..| .|.||||:.|..|   .|||          .:..|.|...| |..
Human   285 YGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDEC----------ASRPCLNGGHCQDLP 339

  Fly   329 NG-TCICNPGWTGAKCAERICEANK----YGLDCNRT-----CECDMEHTDLCHPET-GNCQCSI 382
            || .|.|..|:.|..|.|.:.|...    :|..|:.|     |.|         ||| |...||:
Human   340 NGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVAGYICRC---------PETWGGRDCSV 395

  Fly   383 GWSSAQCTRPCTFLRYGPNCELTCNCKNGAKCSPV------NGTCLCAPGWRGPTC--------- 432
            ..:..|          |..|.|      .|.|.|:      :..|.|.||..||.|
Human   396 QLTGCQ----------GHTCPL------AATCIPIFESGVHSYVCHCPPGTHGPFCGQNTTFSVM 444

  Fly   433 ------------------------------------EESCE------------------------ 437
                                                :||.|
Human   445 AGSPIQASVPAGGPLGLALRFRTTLPAGTLATRNDTKESLELALVAATLQATLWSYSTTVLVLRL 509

  Fly   438 ------PGTFGQ-----------------DCALRCDCQNG-------AKCEP--------ETGQC 464
                  .|.:.|                 .|..|....:|       |...|        :.|..
Human   510 PDLALNDGHWHQVEVVLHLATLELRLWHEGCPARLCVASGPVALASTASATPLPAGISSAQLGDA 574

  Fly   465 LCTAGWKNIKCD----RPCDLNHFGQDCAKVCDCHNNAACNP----QNGSCTCAAGWTGERCERK 521
            ......::::.|    .|.||   |::.  :..|.....|.|    ..|||...  ||..||:
Human   575 TFAGCLQDVRVDGHLLLPEDL---GENV--LLGCERREQCRPLPCVHGGSCVDL--WTHFRCD-- 630

  Fly   522 CDTGKFGHDCAQKCQC----------------------------------------DFNNSLACD 546
            |.....|..||.:...                                        .|.|..|..
Human   631 CARPHRGPTCADEIPAATFGLGGAPSSASFLLQELPGPNLTVSFLLRTRESAGLLLQFANDSAAG 695

  Fly   547 AT--------------------------------------------------NGRCVC--KQDWG 559
            .|                                                  .||.:.  .|.||
Human   696 LTVFLSEGRIRAEVPGSPAVVLPGRWDDGLRHLVMLSFGPDQLQDLGQHVHVGGRLLAADSQPWG 760

  Fly   560 G--------------------VHCETNCRSGYYG--ENCDKVCRCLNNSSCDPD----SGNCI-- 596
            |                    :..:.:.:....|  ::.:....|::...|.||    .|.|:
Human   761 GPFRGCLQDLRLDGCHLPFFPLPLDNSSQPSELGGRQSWNLTAGCVSEDMCSPDPCFNGGTCLVT 825

  Fly   597 -------CSAGWTGADCA-------EPC-PPGFY-----GMEC------KERCPEILHG-NKSCD 634
                   |.|.:||..||       :|| ||...     |..|      :|..|....| |.|..
Human   826 WNDFHCTCPANFTGPTCAQQLWCPGQPCLPPATCEEVPDGFVCVAEATFREGPPAAFSGHNASSG 890

  Fly   635 HITGEIL-----------------------------------CRTGY------------------ 646
            .:.|.:.                                   .|.|:
Human   891 RLLGGLSLAFRTRDSEAWLLRAAAGALEGVWLAVRNGSLAGGVRGGHGLPGAVLPIPGPRVADGA 955

  Fly   647 ---IGLTCEHPC---------------PAGLYG-------------------------------- 661
               :.|..|.|.               |..|.|
Human   956 WHRVRLAMERPAATTSRWLLWLDGAATPVALRGLASDLGFLQGPGAVRILLAENFTGCLGRVALG 1020

  Fly   662 --------------PGCK-------------LKCN---------CEHGGECNHV--TGQCQCLPG 688
                          ||.:             |.|.         |.|.|.|..:  ...|.|.||
Human  1021 GLPLPLARPRPGAAPGAREHFASWPGTPAPILGCRGAPVCAPSPCLHDGACRDLFDAFACACGPG 1085

  Fly   689 WTGSNCNESCPTDTYGQGCAQRCRCVHHKVCRKADGM--CICETGWSGTRC-------------- 737
            |.|..| |:.....:...|| |.||..|     .||.  |.|..|:.|.||
Human  1086 WEGPRC-EAHVDPCHSAPCA-RGRCHTH-----PDGRFECRCPPGFGGPRCRLPVPSKECSLNVT 1143

  Fly   738 --------------DEVCPEGFYGEHC-MNTCAC---PSAN-FQCHAAHG---CVCRSGYTGDNC 780
                          :..|.||..|:.| :.|..|   |..| ..|.||.|   |:|.:.::|..|
Human  1144 CLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFC 1208

  Fly   781 D 781
            :
Human  1209 E 1209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877	2/4 (50%)
		EGF_CA	274..319	CDD:304395	15/64 (23%)
		DSL	<479..518	CDD:302925	11/42 (26%)
		DSL	<567..606	CDD:302925	11/53 (21%)
CRB2	NP_775960.4	Required for maximum inhibition of APP amyloid-beta peptide secretion. /evidence=ECO:0000269\|PubMed:20299451	1..350		89/334 (27%)
		EGF_CA	108..144	CDD:238011	4/35 (11%)
		EGF_CA	147..182	CDD:238011	12/34 (35%)
		EGF_CA	184..221	CDD:238011	14/47 (30%)
		EGF_CA	226..259	CDD:238011	10/33 (30%)
		EGF_CA	321..356	CDD:238011	13/44 (30%)
		EGF_CA	358..393	CDD:238011	10/43 (23%)
		Laminin_G_2	465..588	CDD:280389	12/122 (10%)
		LamG	653..773	CDD:238058	10/119 (8%)
		EGF_CA	812..842	CDD:238011	8/29 (28%)
		LamG	900..1024	CDD:304605	8/123 (7%)
		EGF	1060..1090	CDD:278437	10/29 (34%)
		Interaction with EPB41L5. /evidence=ECO:0000269\|PubMed:17920587	1249..1285
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000