DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drpr and Stab2

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	XP_038934441.1	Gene:	Stab2 / 282580	RGDID:	628822	Length:	2569	Species:	Rattus norvegicus

Alignment Length:	1816	Identity:	321/1816 - (17%)
Similarity:	461/1816 - (25%)	Gaps:	953/1816 - (52%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLPVILIACLAQLVLAQADLKDLDGPNICKRRELYNVDVVYTELQSFQERGSTWCVTFPPRCS-T 64
            :||  ||.....||:..| ....:||.:.||.:..:...:.||.||               || .
  Rat    11 LLP--LIPLFLGLVVQNA-CSPTEGPELAKRCDKKSTLTIKTECQS---------------CSAN 57

  Fly    65 YRIKHRVVNKTKTIAKNRIVRDCCDGYI----ASAG--EC------------VPHCSEPCQHGRC 111
            :.:|                  |.||||    .|||  :|            :|.|...|:.. .
  Rat    58 FAVK------------------CPDGYIKVTSGSAGVRDCRYSLDIQSYVLAIPGCRHICRKD-Y 103

  Fly   112 ISPEKCKCDHGYGGPACDINCPPGWYGRNCSMQCDCLNNAVCE---PFSGDCECAKGYTGARCAD 173
            :.|:.|.   |:.||.| :.||.|       .:..|....||:   ..:|.|.|..|::|..|..
  Rat   104 LQPQCCP---GHWGPDC-MECPGG-------ARAPCGGRGVCDEGMEGTGSCSCQAGFSGTACEA 157

  Fly   174 ICPEGFFGANCSEKCRCENGGKCH---HVSGECQCAPGFTGPLCD--------MRCPDGKHGAQC 227
            ...:..||.|||..|.|.: |.|:   :..|.|:|...:.||.||        :.||:....:..
  Rat   158 CATDNVFGPNCSAVCSCVH-GVCNSGLNGDGTCECLSAYRGPKCDKPIPECATLLCPENSRCSPS 221

  Fly   228 QQD-----CPC----QNDGK------------CQPETG---------ACMCNPGWTGD--VCA-- 258
            .:|     |.|    :.||.            |.|...         :|:|..|:.||  ||.
  Rat   222 SKDETKLQCKCLPNYEGDGHNCRPINPCLKTICHPHASCSYLGPNRHSCICQKGYQGDGQVCLPV 286

  Fly   259 -------NKCP----VGSY-GPG-----CQES---------------CE----CYKGAPCHHIT- 286
                   .|||    |..| |||     |:|.               ||    |:|.|.|..::
  Rat   287 DPCQTNYGKCPPESTVCKYDGPGQSHCECKEHYRNFVPGVGCSMTDICESNNPCHKNANCSTVSP 351

  Fly   287 --GQCECPPGYRGE--RCFDEC-----QLN--------------------TYGFNCS-------- 314
              .:|.|..||.|:  .|:...     :||                    ||.:..|
  Rat   352 GKTKCTCQKGYVGDGLNCYGNIMQRLRELNTEPRGMWQGQLTSFISILDRTYAWPLSNLGPFTVL 416

  Fly   315 ----------------MTCDCAN------------------------------------------ 321
                            |..:.|.
  Rat   417 LPSDKGLKGVDVKELLMDKEAARYFAKLHIIAGQMSMEQMYHLDTFYTLTGKSGEIFNKDKDNQL 481

  Fly   322 ---------------------------DAMCDRANGTCICNPGWT-------------------- 339
                                       |...|:...|...||..|
  Rat   482 KLKLHGSKVVKIIQGNIVASNGLVHILDRAMDKTEPTFASNPQQTIMAMLQPRYGRFRSLLEKTN 546

  Fly   340 ------------------------------------GAK-------------------------- 342
                                                |::
  Rat   547 VGQILDEGGPYTIFVPSNEALSNMKADILDYLLSPEGSRKLLELVRYHIVAFTQLEVATLVSTPH 611

  Fly   343 ---CAERICE----------ANKYGLD------------------------------CNR----- 359
               .|.:|.:          ||...:|                              ||.
  Rat   612 IRSMANQIIKFNITSKGQILANNVAMDETEVAAKNGRIYTLTGVLIPPSILPILPHRCNETKIEL 676

  Fly   360 ---TC-ECDMEHTDLC----HPETGNCQCSIGWSS------AQCTRPCTFLRYGPNCELTCNCKN 410
               || .|..:|...|    .|.|....|.  :||      :.|.|.|......|.|     ||.
  Rat   677 KLGTCVSCSTKHWSKCPADSKPATIFSSCF--YSSRVRNLKSGCARYCNVTVEIPRC-----CKG 734

  Fly   411 --GAKCSPV--------------------NGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQN 453
              |..|:|.                    ||||:|..|::|..|:...:|..:|..|...|.|.:
  Rat   735 FFGPDCTPCPGGFLTPCSGNGQCMDGLAGNGTCICQDGFQGSMCQFCSDPNRYGPRCNRTCLCVH 799

  Fly   454 GAKCE---PETGQCL---CTAGWKNIKCDRPCDLNHFGQDCAK-VCDCHNNAACNPQN--GSCTC 509
            |. |:   ...|.||   |..|.....||:....      |.. |..||.:|:|...|  .||.|
  Rat   800 GT-CDNRLDSDGACLSGTCREGTAGRFCDKQTSA------CGPYVQFCHIHASCEYSNKTASCVC 857

  Fly   510 AAGWTGE--RCERKCD----TGKFGHDCAQKCQCDFNNSLACDATNGRCVCKQDW---------- 558
            ..|:.|:  .|.:|..    |.:.|  |:...:|     :........|||:|.|
  Rat   858 NEGYEGDGVLCSKKDPCLGLTSRGG--CSPNAEC-----IQTSTGTYSCVCQQGWTGNGRDCVGI 915

  Fly   559 --------GGVH----C--------ETNCRSGYYGE--NCDKVCRCLNNS-SCDP-------DSG 593
                    ||.|    |        |..|:.|:.|.  :|:.:..||..: .|.|       .||
  Rat   916 NNCLLPSSGGCHDNATCLYVGPGQNECECKKGFRGNGIDCEPIISCLEQTEKCHPLATCQSTSSG 980

  Fly   594 --NCICSAGWTG----------------------------------------ADCAEPCPPGFYG 616
              :|:|..|:.|                                        .....|....|..
  Rat   981 VWSCVCREGYEGNGVLCYGNVLMELSFLPEAAVFYQWINNASLQSVLSTTSNLTVLVPSRRAFED 1045

  Fly   617 MECKER-------------------------------CPEIL--------------HGNKSCD-- 634
            |:..|:                               .|.:|              .||.:.:
  Rat  1046 MDQNEKSFWLSRNNIPALIKYHILLGKYGVADLQALSSPHMLATSLQGNFLQLDKADGNITIEGA 1110

  Fly   635 --------------HITGEILCR------------------------TGYI-------------- 647
                          ||..::|..                        .|||
  Rat  1111 SIVDGDNAATNGVVHIINKVLVPQRGLTGSLPSLLTRLEQMPGYSIFRGYIIHYNLASAIEAADA 1175

  Fly   648 ----------------------------------------------------------------- 647

  Rat  1176 YTVFVPNNEAIENYIREKKATSLKEDILRYHVVLGEKLLKNDLHNGMHRETMLGFSYLLAFFLRN 1240

  Fly   648 -----------------------GL---------TCEH-----------------PCP------- 656
                                   ||         .|::                 |||
  Rat  1241 DQLYVNEAPINYTNVATDKGVIHGLEKVLEIQKNRCDNNDTIIVRGECGKCSQQAPCPLETKPLR 1305

  Fly   657 -----------------------------------AGLYGPGCKLKCN------CEHGGEC---N 677
                                               ||.:||.|: .|.      |...|.|   .
  Rat  1306 ETRKCIYSIYFMGKRSVFIGCQPQCVRTIITRACCAGFFGPQCQ-ACPGRGQNVCSGNGFCLDGV 1369

  Fly   678 HVTGQCQCLPGWTGSNCNESCPTDTYGQGCAQRCRCVHHKVCRK---ADGMCICETGWSGTRCD- 738
            :.||.|||..|::|:.| |:|....||..|.|.|.|||.: |.:   .||.|.|:.||.|.:||
  Rat  1370 NGTGTCQCGLGFSGTAC-ETCTEGKYGIHCDQACSCVHGR-CSQGPLGDGSCDCDVGWRGVKCDM 1432

  Fly   739 EV--------------------------CPEGFYGEH--CMNTCACPSANFQCHAA--------- 766
            |:                          |..||.|..  |....||.::|..|...
  Rat  1433 EITTDNCNGTCHTSANCLLDPDGKASCKCAAGFRGNGTVCTAINACETSNGGCSTKADCKRTTPG 1497

  Fly   767 -HGCVCRSGYTGD---------------NCDELIASQRIADQSENSSRASVA------------- 802
             ..|||::|||||               .||      |.|:.::.....:|.
  Rat  1498 NRVCVCKAGYTGDGIVCLEINPCLENHGGCD------RNAECTQTGPNQAVCNCLPKYTGDGKVC 1556

  Fly   803 --LTLVLMTLFACIIFAVFIYYR--RRVSNLKTEIAHVHYTHD------TNPPSWPPNHNFDNPV 857
              :.:.|.....|..||...|..  :|:...|.:     ||.|      :.....|.|.:.....
  Rat  1557 SLINVCLTNNGGCSPFAFCNYTEQDQRICTCKPD-----YTGDGIVCRGSIYGELPKNPSTSQYF 1616

  Fly   858 YGMQAE-----------TRLLP----NNMRSKMNNFDQRSTMSTDYGDDCNASGRVGSYSINYNH 907
            :.:|..           |...|    .|...::.::||:..||           :|..|.:....
  Rat  1617 FQLQEHAVRELAGPGPFTVFAPLSSSFNHEPRIKDWDQQGLMS-----------QVLRYHVVGCQ 1670

  Fly   908 DLLTKNLNADRTNPIVYNE----SLKEEHVYDEIKHKEGYKD------PVKIYSKILFPED 958
            .||..||....:...:..|    |:.::.|:...:.|....|      .:.:..|:|.|::
  Rat  1671 QLLLDNLKVTTSATTLQGEPVSISVSQDTVFINNEAKVLSSDIISTNGVIHVIDKLLSPKN 1731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877	12/65 (18%)
		EGF_CA	274..319	CDD:304395	18/102 (18%)
		DSL	<479..518	CDD:302925	12/43 (28%)
		DSL	<567..606	CDD:302925	14/90 (16%)
Stab2	XP_038934441.1	EGF_CA	254..283	CDD:419698	7/28 (25%)
		EGF_3	334..369	CDD:403986	11/34 (32%)
		Fasciclin	390..512	CDD:396845	6/121 (5%)
		Fasciclin	533..658	CDD:396845	6/124 (5%)
		EGF_3	840..868	CDD:403986	10/27 (37%)
		EGF_3	881..912	CDD:403986	8/37 (22%)
		EGF_3	923..955	CDD:403986	8/31 (26%)
		EGF_3	961..997	CDD:403986	10/35 (29%)
		Fasciclin	1014..1133	CDD:396845	11/118 (9%)
		Fasciclin	1152..1269	CDD:396845	5/116 (4%)
		EGF_3	1478..1514	CDD:403986	11/35 (31%)
		EGF_3	1520..1556	CDD:403986	5/41 (12%)
		EGF_3	1562..1598	CDD:403986	10/40 (25%)
		Fasciclin	1629..1729	CDD:396845	20/110 (18%)
		Fasciclin	1754..1885	CDD:396845
		EGF_CA	2059..2084	CDD:419698
		EGF_3	2090..2125	CDD:403986
		EGF_3	2131..2168	CDD:403986
		Link_Domain	2202..2294	CDD:413401
		FAS1	2360..2449	CDD:214719
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900