DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drpr and DKK4

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_055235.1	Gene:	DKK4 / 27121	HGNCID:	2894	Length:	224	Species:	Homo sapiens

Alignment Length:	191	Identity:	45/191 - (23%)
Similarity:	62/191 - (32%)	Gaps:	48/191 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 RGERCFDECQLNTYGFNC---------SMTC-----DCANDAMCDRANGTCICNPGWTGAKCAER 346
            :|.:|..:...||..| |         ..||     .|..||||        |    .|..|...
Human    37 KGSQCLSDTDCNTRKF-CLQPRDEKPFCATCRGLRRRCQRDAMC--------C----PGTLCVND 88

  Fly   347 ICEANKYGLDCNRTCECDMEHTDLCHPE--TGN--------CQCSIGWSSAQCTRPCTFLRYGPN 401
            :|...:   |.....|..::..|..|.|  ||:        .:.||..|..:..:.      |.:
Human    89 VCTTME---DATPILERQLDEQDGTHAEGTTGHPVQENQPKRKPSIKKSQGRKGQE------GES 144

  Fly   402 CELTCNCKNGAKCSPVNGTCLCAPG-WRGPTCEESCEPGTF-GQDCALRCDCQNGAKCEPE 460
            |..|.:|..|..|:....|.:|.|. ..|..|.......|. ..:...||||..|..|..:
Human   145 CLRTFDCGPGLCCARHFWTKICKPVLLEGQVCSRRGHKDTAQAPEIFQRCDCGPGLLCRSQ 205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395	8/36 (22%)
		DSL	<479..518	CDD:302925
		DSL	<567..606	CDD:302925
DKK4	NP_055235.1	Dickkopf_N	41..91	CDD:309719	15/62 (24%)
		DKK-type Cys-1	41..90		15/61 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..139		7/29 (24%)
		DKK-type Cys-2	145..218		17/61 (28%)
		Prokineticin	<145..202	CDD:148298	16/56 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900