DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drpr and GAS6

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_000811.1	Gene:	GAS6 / 2621	HGNCID:	4168	Length:	678	Species:	Homo sapiens

Alignment Length:	345	Identity:	80/345 - (23%)
Similarity:	109/345 - (31%)	Gaps:	118/345 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   315 MTCDCANDAMCDRANGTCICNP--------------GWTGAKCAERICEANKYGLDCNRTCECDM 365
            :..:||..|:......|....|              |....:|.|.:|...    :.....|.|.
Human    23 LAAECALAALLPAREATQFLRPRQRRAFQVFEEAKQGHLERECVEELCSRE----EAREVFENDP 83

  Fly   366 EHTDLCHPETGNCQCSIGWSSAQCTRPCTFLRYGPNCELTCNCKNGAKCSPVNGTCLCAPGWRGP 430
            | ||..:|                       ||     |.|..|.|:..:..:|...|.     .
Human    84 E-TDYFYP-----------------------RY-----LDCINKYGSPYTKNSGFATCV-----Q 114

  Fly   431 TCEESCEPGTFGQDCALRCDCQNGAKCEPETGQ--CLCTAGWKNIKCDRPCDLNHFGQD---CAK 490
            ...:.|.|..        ||.:....|:...|.  |||.|||....||:  |:|...|:   |.:
Human   115 NLPDQCTPNP--------CDRKGTQACQDLMGNFFCLCKAGWGGRLCDK--DVNECSQENGGCLQ 169

  Fly   491 VCDCHNNAACNPQNGSCTCAAGWTGERCERKCDTGKFGHDCAQKCQCDFNNSLACDATNGRCVCK 555
            :  |||    .|.:..|:|.:|:     |...|    |..|....:|  .:|.||    |...||
Human   170 I--CHN----KPGSFHCSCHSGF-----ELSSD----GRTCQDIDEC--ADSEAC----GEARCK 213

  Fly   556 QDWGGVHCETNCRSGYYGENCDKVCRCLNNSSCDPDSGNCICSAGWTGADCAEPC--PPGFYGME 618
            ...|...|  .|..|:...:.:|.||       |.|.    |..|    .|.:.|  .||.|...
Human   214 NLPGSYSC--LCDEGFAYSSQEKACR-------DVDE----CLQG----RCEQVCVNSPGSYTCH 261

  Fly   619 CKER-----------CPEIL 627
            |..|           |.:||
Human   262 CDGRGGLKLSQDMDTCEDIL 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395	0/3 (0%)
		DSL	<479..518	CDD:302925	11/41 (27%)
		DSL	<567..606	CDD:302925	9/38 (24%)
GAS6	NP_000811.1	Gla	53..92	CDD:306960	10/66 (15%)
		EGF_CA	118..153	CDD:238011	12/42 (29%)
		FXa_inhibition	160..195	CDD:317114	12/49 (24%)
		EGF_CA	197..>227	CDD:214542	10/37 (27%)
		vWFA	<232..273	CDD:320736	14/55 (25%)
		LamG	298..450	CDD:238058
		Laminin_G_2	513..651	CDD:308045
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24035
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100