Protein Alignment drpr and Kdr

DIOPT Version :9

• Sequence 1: NP_001261276.1
• Gene: drpr / 38218
• FlyBaseID: FBgn0027594
• Length: 1042
• Species: Drosophila melanogaster
• Sequence 2: NP_037194.2
• Gene: Kdr / 25589
• RGDID: 2965
• Length: 1343
• Species: Rattus norvegicus
• Alignment Length: 417
• Identity: 76/417 - (18%)
• Similarity: 113/417 - (27%)
• Gaps: 184/417 - (44%)

  Fly   262 PVGSYGPGCQE--SCECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCDCANDAM 324
            |:.||..|..:  :|..|...|.|||....:          .:|.
  Rat   431 PMDSYQYGTMQTLTCTVYANPPLHHIQWYWQ----------LEEA-------------------- 465

  Fly   325 CDRANGTCICNPGWTGAKCAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSAQC 389
                              |:.|..:.|.|      ||:           |..:.:...|.:..:.
  Rat   466 ------------------CSYRPSQTNPY------TCK-----------EWRHVKDFQGGNKIEV 495

  Fly   390 TRPCTFLRYGPNCELT------CNCKNGAKCSPVNGT-----CLCAPGWRGPTCEESCEPGTFGQ 443
            |:....|..|.|..::      .|.....||..:|..     .:.....|||  |.:.:|.|
  Rat   496 TKNQYALIEGKNKTVSTLVIQAANVSALYKCEAINKAGRGERVISFHVIRGP--EITVQPAT--- 555

  Fly   444 DCALRCDCQNGAKCEPETGQCLCTAG---WKNI---KCDRPCDLNHFGQDCAKVCDCHNNAACNP 502
                       ...|.|:...||||.   ::|:   |........|.|:....|  |.|..|...
  Rat   556 -----------QPTEQESVSLLCTADRNTFENLTWYKLGSQATSVHMGESLTPV--CKNLDALWK 607

  Fly   503 QNGSCTCAAGWTGERCERKCDTGKFGHDCAQKCQCDFNNSLACDATNGRCVCKQDWGGVHCETNC 567
            .||:.                               |:||                      ||
  Rat   608 LNGTV-------------------------------FSNS----------------------TN- 618

  Fly   568 RSGYYGENCDKVCRCLNNSSCDPDSGNCICSAGWTGADCAEPCPPGFYGMECKER-C--PEILHG 629
                     |.:.....|:|.. |.||.:|||               ...:.|:| |  .:::..
  Rat   619 ---------DILIVAFQNASLQ-DQGNYVCSA---------------QDKKTKKRHCLVKQLVIL 658

  Fly   630 NKSCDHITGEILCRTGYIGLTCEHPCP 656
            .:....|||.:..:|..||.|.|..||
  Rat   659 ERMAPMITGNLENQTTTIGETIEVVCP 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395	7/44 (16%)
		DSL	<479..518	CDD:302925	8/38 (21%)
		DSL	<567..606	CDD:302925	9/38 (24%)
Kdr	NP_037194.2	Ig	224..325	CDD:416386
		Ig strand A	224..228	CDD:409353
		Ig strand A'	234..238	CDD:409353
		Ig strand B	240..249	CDD:409353
		Ig strand C	256..261	CDD:409353
		Ig strand C'	264..266	CDD:409353
		Ig strand D	270..278	CDD:409353
		Ig strand E	286..294	CDD:409353
		Ig strand F	304..310	CDD:409353
		Ig strand G	315..321	CDD:409353
		Ig	329..417	CDD:416386
		Ig strand A	329..332	CDD:409353
		Ig strand A'	339..343	CDD:409353
		Ig strand B	345..356	CDD:409353
		Ig strand C	360..366	CDD:409353
		Ig strand C'	368..371	CDD:409353
		Ig strand D	376..379	CDD:409353
		Ig strand E	381..386	CDD:409353
		Ig strand F	394..402	CDD:409353
		Ig strand G	408..417	CDD:409353
		Ig_3	547..641	CDD:404760	34/190 (18%)
		IGc2	676..740	CDD:197706	6/10 (60%)
		Ig strand B	680..684	CDD:409353	1/3 (33%)
		Ig strand C	693..697	CDD:409353
		Ig strand E	716..720	CDD:409353
		Ig strand F	730..735	CDD:409353
		VEGFR-2_TMD	755..789	CDD:375470
		PTKc_VEGFR2	822..1163	CDD:270681
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1267..1314

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900