DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drpr and TMEFF2

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_057276.2	Gene:	TMEFF2 / 23671	HGNCID:	11867	Length:	374	Species:	Homo sapiens

Alignment Length:	281	Identity:	70/281 - (24%)
Similarity:	96/281 - (34%)	Gaps:	86/281 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 ECQLNTYGFNCS---------MTCD---CANDAMCDRANG--TCICNPGWTGAKCAE---RICEA 350
            :||..| |:|||         ..||   |..|..|.|...  ||:|.     .||..   .:|.:
Human    47 DCQTPT-GWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQ-----FKCNNDYVPVCGS 105

  Fly   351 N--KYGLDCN-RTCECDMEHTDLCHPETGNCQCSI------------GWSSAQCTRPCTFLRYGP 400
            |  .|..:|. |...|..:...|...| |:|....            |.:|.:.|..|...::|.
Human   106 NGESYQNECYLRQAACKQQSEILVVSE-GSCATDAGSGSGDGVHEGSGETSQKETSTCDICQFGA 169

  Fly   401 NC-----ELTCNCKNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQNGAKCE-P 459
            .|     ::.|.|  ...||..|...|||..  |.:.:.:|:        .....||...|.| .
Human   170 ECDEDAEDVWCVC--NIDCSQTNFNPLCASD--GKSYDNACQ--------IKEASCQKQEKIEVM 222

  Fly   460 ETGQCLCTAGWKNIKCDRPCDLNHFGQ-DCAK--------------VCDCHNNAAC--------- 500
            ..|:|     ..|.......:..|:.: |.|:              .|..|.|..|
Human   223 SLGRC-----QDNTTTTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSI 282

  Fly   501 NPQNGSCTCAAGWTGERCERK 521
            |.|..||.|.||:||:.||:|
Human   283 NMQEPSCRCDAGYTGQHCEKK 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395	9/27 (33%)
		DSL	<479..518	CDD:302925	16/62 (26%)
		DSL	<567..606	CDD:302925
TMEFF2	NP_057276.2	KAZAL_FS	95..135	CDD:238052	10/40 (25%)
		KAZAL	181..227	CDD:197624	14/57 (25%)
		PHA02887	<236..301	CDD:165214	16/64 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000