DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drpr and Dkk4

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_663567.1	Gene:	Dkk4 / 234130	MGIID:	2385299	Length:	221	Species:	Mus musculus

Alignment Length:	243	Identity:	55/243 - (22%)
Similarity:	72/243 - (29%)	Gaps:	101/243 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 GAKCA-ERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSAQCTRPCTFLRYGPNCE 403
            |:.|| :|.|...|:.|              ..|.|...|        |.|.|
Mouse    38 GSLCASDRDCSEGKFCL--------------AFHDERSFC--------ATCRR------------ 68

  Fly   404 LTCNCKNGAKCSP----VNGTCLCAPGWRGPTCEESCEP----GTFGQDCALRCDC------QNG 454
            :...|:..|.|.|    ||..|         |..|...|    .|.|||.|.....      :|.
Mouse    69 VRRRCQRSAVCCPGTVCVNDVC---------TAVEDTRPVMDRNTDGQDGAYAEGTTKWPAEENR 124

  Fly   455 AKCEPETGQCLCTAGWKNIKCDRPCDLNHFGQDCAKVCDCHNNAACNPQNGSCTCAAGWT----- 514
            .:.:|.|.:...:.|.:             |:.|.:..|      |.|  |.|.....||
Mouse   125 PQGKPSTKKSQSSKGQE-------------GESCLRTSD------CGP--GLCCARHFWTKICKP 168

  Fly   515 ----GERCERKCDTGKFGH-DCAQKCQ----CDFNNSLAC--DATNGR 551
                |:.|.|:      || |.||..:    ||....|.|  ..|:.|
Mouse   169 VLREGQVCSRR------GHKDTAQAPEIFQRCDCGPGLTCRSQVTSNR 210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395
		DSL	<479..518	CDD:302925	10/47 (21%)
		DSL	<567..606	CDD:302925
Dkk4	NP_663567.1	Dickkopf_N	41..91	CDD:368068	19/92 (21%)
		DKK-type Cys-1	41..90		18/82 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..143		9/54 (17%)
		DKK-type Cys-2	145..218		22/80 (28%)
		Prokineticin	<145..202	CDD:148298	19/70 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900