Protein Alignment drpr and Megf6

DIOPT Version :10

• Sequence 1: NP_001261276.1
• Gene: drpr / 38218
• FlyBaseID: FBgn0027594
• Length: 1042
• Species: Drosophila melanogaster
• Sequence 2: NP_001156449.1
• Gene: Megf6 / 230971
• MGIID: 1919351
• Length: 1572
• Species: Mus musculus
• Alignment Length: 825
• Identity: 308/825 - (37%)
• Similarity: 416/825 - (50%)
• Gaps: 89/825 - (10%)

  Fly    22 DLDG--PNICKRRELYNVDVVYTEL-QSFQERGSTWCVTFPPRCSTYRIKHRVVNKTK---TIAK 80
            ||||  |.:   |.|.::.|:..|| |.||:              .|..:...|.:.:   |:.:
Mouse   462 DLDGQLPFV---RPLPHIAVLGDELPQLFQD--------------DYGAEEEAVAELRGEHTLTE 509

  Fly    81 NRIVRDCCDGYIASAGECVPHCSEPCQHGRCISP--EKCKCDHGYGGPACDINCPPGWYGRNCSM 143
            ..:..|...|:     :|...|.: |::|....|  :.|.|..|:.|..|:..|||..:|:|||.
Mouse   510 KFVCLDHSFGH-----DCSLTCDD-CRNGGTCFPGLDGCDCPEGWTGIICNETCPPDTFGKNCSS 568

  Fly   144 QCDCLNNAVCEPFSGDCECAKGYTGARCADICPEGFFGANCSEKCRCENGGKCHHVSGECQCAPG 208
            .|.|.|...|:|.||.|.|..|.:||.|.|.||:||:|.:|.:||.|.|.|:||.:.|.|.|.||
Mouse   569 PCICQNGGTCDPVSGACRCPPGVSGAHCEDGCPKGFYGKHCRKKCHCANRGRCHRLYGACLCDPG 633

  Fly   209 FTGPLCDMRCPDGKHGAQCQQDCPCQ--NDGKCQPETGACMCNPGWTGDVCANKCPVGSYGPGCQ 271
            ..|..|.:.||....|..|.:||.|:  :...|..:.|:|.|..|:.|:.|..:|..||:||||:
Mouse   634 LYGRFCHLACPPWAFGPGCSEDCLCEQSHTRSCNSKDGSCSCKAGFQGERCEAECEPGSFGPGCR 698

  Fly   272 ESCECYKGAPCHHITGQC--ECPPGYRGERCFDECQLNTYGFNCSMTC----------------- 317
            ..|.|..|..|..::|:|  :|||||:||.|..||.:.|:|.|||.:|
Mouse   699 NRCTCRPGVACDPVSGECRTQCPPGYQGEDCGQECPVGTFGVNCSGSCSCVGAPCHRVTGECLCP 763

  Fly   318 ------DCAND--------------------AMCDRANGTCICNPGWTGAKCAERICEANKYGLD 356
                  ||..|                    |.||...|||:|.||:.|::|.: .|.|..:|..
Mouse   764 PGKTGEDCGADCPEGRWGLGCQEICPACEHGASCDPETGTCLCLPGFVGSRCQD-ACPAGWFGTG 827

  Fly   357 CNRTCECDME-HTDLCHPETGNCQCSIGWSSAQCTRPCTFLRYGPNCELTCNCKNG-AKCSPVNG 419
            |...|.|..: |   |||.||.|.|:.||:...|.|.|....:||:|...|||..| ..|..|:|
Mouse   828 CQMRCACANDGH---CHPATGRCSCAPGWTGLSCQRACDSGHWGPDCIHPCNCSAGHGNCDAVSG 889

  Fly   420 TCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQNGAKCEPETGQCLCTAGWKNIKCDRPCDLNHF 484
            .|||..|:.||.||:.|..|.||..|..:|.|::||.|:..:|.|.|.|||:...|:..|....|
Mouse   890 LCLCEAGYEGPQCEQWCRQGYFGPGCEQKCRCEHGATCDHVSGACTCPAGWRGSFCEHACPAGFF 954

  Fly   485 GQDCAKVCDCHNNAACNPQNGSCTCAAGWTGERCERKCDTGKFGHDCAQKCQCDFNNSLACDATN 549
            |.||...|:|...|.|:...|||.|.||..|..|.:.|....||.:|:|.|.| ||.: :||...
Mouse   955 GLDCGSACNCSAGAPCDAVTGSCICPAGRWGPHCAQTCPPLTFGLNCSQICTC-FNGA-SCDPVL 1017

  Fly   550 GRCVCKQDWGGVHCETNCRSGYYGENCDKVCRCLNNSSCDPDSGNCICSAGWTGADCAEPCPPGF 614
            |:|.|...|.|..|...|.:|.||:||...|.|.|..:|||..|.|.|..||||..|...|.||.
Mouse  1018 GQCHCAPGWMGPTCLQACPAGLYGKNCQHSCLCRNGGNCDPILGQCTCPEGWTGLACENECLPGH 1082

  Fly   615 YGMECKERCPEILHGNKSCDHITGEILCRTGYIGLTCEHPCPAGLYGPGCKLKCNCEHGGECNHV 679
            :|..|:..| ..|:|. :||.:||...|.||:.|..|:.||.:|::|..|:..|.|..|..|:||
Mouse  1083 HGAGCRLNC-SCLNGG-TCDRLTGHCRCPTGWTGDKCQSPCVSGMFGVHCEEHCACRKGATCHHV 1145

  Fly   680 TGQCQCLPGWTGSNCNESCPTDTYGQGCAQRCRCVHHKVCRKADGMCICETGWSGTRCDEVCPEG 744
            ||.|.|.|||.||:|.::||...:|:.|||||.|.....|....|.|.|..|::|..|::.|..|
Mouse  1146 TGACLCPPGWRGSHCEQACPRGWFGEACAQRCHCPPGASCHHVSGECHCPPGFTGPGCEQACQPG 1210

  Fly   745 FYGEHCMNTCACPSANFQCHAAHG-CVCRSGYTGDNCDELIASQR 788
            .:|:.|.:.|.||...:.||.|.| |||.:||.|.:|.:...|.|
Mouse  1211 TFGKDCEHPCQCPGETWACHPASGACVCAAGYHGTDCQQRCPSGR 1255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	26..92	CDD:462204	14/69 (20%)
		EGF_CA	274..319	CDD:473889	22/69 (32%)
		gliding_CglD	<451..579	CDD:468178	51/127 (40%)
		DSL	567..609	CDD:473190	20/41 (49%)
Megf6	NP_001156449.1	EMI	41..112	CDD:462204
		FXa_inhibition	126..161	CDD:464251
		vWFA	<153..201	CDD:469594
		FXa_inhibition	208..244	CDD:464251
		FXa_inhibition	250..285	CDD:464251
		vWFA	<283..324	CDD:469594
		FXa_inhibition	337..372	CDD:464251
		vWFA	<370..409	CDD:469594
		vWFA	<412..451	CDD:469594