Protein Alignment drpr and DKK1

DIOPT Version :10

• Sequence 1: NP_001261276.1
• Gene: drpr / 38218
• FlyBaseID: FBgn0027594
• Length: 1042
• Species: Drosophila melanogaster
• Sequence 2: NP_036374.1
• Gene: DKK1 / 22943
• HGNCID: 2891
• Length: 266
• Species: Homo sapiens
• Alignment Length: 281
• Identity: 56/281 - (19%)
• Similarity: 79/281 - (28%)
• Gaps: 101/281 - (35%)

  Fly   193 GGKCHHVSGECQCAPGFTGPLCDMRCPDGKHGAQC---QQDCPCQNDGKCQPETGACMCNPGWTG 254
            ||...|.......|||...|        |.:..|.   .|..||..|.:|            .|.
Human    50 GGAAGHPGSAVSAAPGILYP--------GGNKYQTIDNYQPYPCAEDEEC------------GTD 94

  Fly   255 DVCANKCPVGSYGPGCQESC-----ECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCS 314
            :.||:....|..|.....:|     .|.:.|.|        ||..|        |:
Human    95 EYCASPTRGGDAGVQICLACRKRRKRCMRHAMC--------CPGNY--------CK--------- 134

  Fly   315 MTCDCANDAMCDRANGTCI-CNPGWTGAKCAERICEA--NKY----GLDCNRTCECDMEHTDLCH 372
                          ||.|: .:......:..|.|.|:  |.:    |.....|....|.||.
Human   135 --------------NGICVSSDQNHFRGEIEETITESFGNDHSTLDGYSRRTTLSSKMYHTK--- 182

  Fly   373 PETGNCQCSIGWSSAQCTRPCTFLRYGPNCELTCNCKNGAKCSPVNGTCLCAPGWR-GPTCEESC 436
                      |...:.|.|             :.:|.:|..|:....:.:|.|..: |..|.:..
Human   183 ----------GQEGSVCLR-------------SSDCASGLCCARHFWSKICKPVLKEGQVCTKHR 224

  Fly   437 EPGTFGQDCALRCDCQNGAKC 457
            ..|:.|.:...||.|..|..|
Human   225 RKGSHGLEIFQRCYCGEGLSC 245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	26..92	CDD:462204
		EGF_CA	274..319	CDD:473889	8/49 (16%)
		gliding_CglD	<451..579	CDD:468178	3/7 (43%)
		DSL	567..609	CDD:473190
DKK1	NP_036374.1	Dkk1_N_Cys1	16..139	CDD:438010	29/147 (20%)
		DKK-type Cys-1	85..138		18/103 (17%)
		Dkk1_Cys2	182..264	CDD:437998	17/90 (19%)
		DKK-type Cys-2	189..263		16/70 (23%)