Protein Alignment drpr and LAMB4

DIOPT Version :10

• Sequence 1: NP_001261276.1
• Gene: drpr / 38218
• FlyBaseID: FBgn0027594
• Length: 1042
• Species: Drosophila melanogaster
• Sequence 2: XP_011514277.1
• Gene: LAMB4 / 22798
• HGNCID: 6491
• Length: 1772
• Species: Homo sapiens
• Alignment Length: 1287
• Identity: 274/1287 - (21%)
• Similarity: 398/1287 - (30%)
• Gaps: 528/1287 - (41%)

  Fly     9 CLAQLVLAQADLKDLDGPNICKRRELYNVDVVYTELQSFQERG--STWCVTFPPRC----STY-- 65
            |:.|        .:.|||| |:|.:.:..|..:......|:..  |..|.:...||    :||
Human   295 CVCQ--------HNTDGPN-CERCKDFFQDAPWRPAADLQDNACRSCSCNSHSSRCHFDMTTYLA 350

  Fly    66 ----------RIKHRVVNK-------------TKTIAKNRIVRDC-C--DGYIASAGECVPHCSE 104
                      ..:|....:             .|||:.......| |  ||.| |.|.||.| |:
Human   351 SGGLSGGVCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYACIPCECDPDGTI-SGGICVSH-SD 413

  Fly   105 PC---QHGRCISPEKCKCDHGYGGPACDINCPPGWYGRNCS-----MQCDC-----LNNAVCEPF 156
            |.   ..|:|:      |.....|..|| .|.|..||.:.:     ..|||     |....|:..
Human   414 PALGSVAGQCL------CKENVEGAKCD-QCKPNHYGLSATDPLGCQPCDCNPLGSLPFLTCDVD 471

  Fly   157 SGDCECAKGYTGARCADICPEGFFGA-----NCSEKCRCENGGK----CHHVSGECQCAPGFTGP 212
            :|.|.|....|||.|.: |..|::|.     .|| .|.|:.||.    |...:|:|:|.|..||.
Human   472 TGQCLCLSYVTGAHCEE-CTVGYWGLGNHLHGCS-PCDCDIGGAYSNVCSPKNGQCECRPHVTGR 534

  Fly   213 LCDMRCP------------DGKHGAQCQQDCPCQND------------GKCQPETGACMCNPG-- 251
            .|....|            :.:.....|...|..::            |:..|........||
Human   535 SCSEPAPGYFFAPLNFYLYEAEEATTLQGLAPLGSETFGQSPAVHVVLGEPVPGNPVTWTGPGFA 599

  Fly   252 ----------------------------------WTGDVCANKCPVGS----------------- 265
                                              ||..:..|. |.||
Human   600 RVLPGAGLRFAVNNIPFPVDFTIAIHYETQSAADWTVQIVVNP-PGGSEHCIPKTLQSKPQSFAL 663

  Fly   266 ----------------------------------------------------------------- 265
                                                                             
Human   664 PAATRIMLLPTPICLEPDVQYSIDVYFSQPLQGESHAHSHVLVDSLGLIPQINSLENFCSKQDLD 728

  Fly   266 -------------YGP-----GCQE--------------SCECYK----GAPCHHITGQCECPPG 294
                         .||     .|:.              :|:|:.    |:.|..:.|||:|.|.
Human   729 EYQLHNCVEIASAMGPQVLPGACERLIISMSAKLHDGAVACKCHPQGSVGSSCSRLGGQCQCKPL 793

  Fly   295 YRGERCFDECQLNTY--GFNCSMTCDC----ANDAMCDRANGTCICNPGWTGAKCAERICEANKY 353
            ..| ||.|.|...:|  |.:....|.|    :.|.:||:..|.|.|:...:|.:|..  |.|..:
Human   794 VVG-RCCDRCSTGSYDLGHHGCHPCHCHPQGSKDTVCDQVTGQCPCHGEVSGRRCDR--CLAGYF 855

  Fly   354 GLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSAQCTRPCTFLRYGPNCELTCNCKNGAKCSPVN 418
            |......|.|: ...:||.||||:|....|:::            |.|||
Human   856 GFPSCHPCPCN-RFAELCDPETGSCFNCGGFTT------------GRNCE--------------- 892

  Fly   419 GTCLCAPGWRG-PTCEESCEPGTFGQDCALRCDCQNGAKCEPETGQCLCTAGWKNIKCDRPCDLN 482
               .|..|:.| |:..:.|.|                         |||.        |.|....
Human   893 ---RCIDGYYGNPSSGQPCRP-------------------------CLCP--------DDPSSNQ 921

  Fly   483 HFGQDCAKVCDCHNNAACNPQNGSCTCAAGWTGERCERKCDTGKFGH------DCAQKCQCDFNN 541
            :|..      .|:.|...:  :..|.|..|:||.:| .:|.||.:|:      .| |.|.|  ||
Human   922 YFAH------SCYQNLWSS--DVICNCLQGYTGTQC-GECSTGFYGNPRISGAPC-QPCAC--NN 974

  Fly   542 SL------ACDATNGRCV-CKQDWGGVHCETNCRSGYYGENCDKVCRCLNNSSCDPDSGNCICSA 599
            ::      :|....|.|: |..:..|.:|:. |:.|:||...::.||            .|.|.|
Human   975 NIDVTDPESCSRVTGECLRCLHNTQGANCQL-CKPGHYGSALNQTCR------------RCSCHA 1026

  Fly   600 GWTGADCAEPCPPGFYGMECKERCPEILHGNKSCDHITGEILCRTGYIGLTCEHPCPAGLY---- 660
              :|....| ||||  |..|            .||.:||...|.....||.|:. |..|.:
Human  1027 --SGVSPME-CPPG--GGAC------------LCDPVTGACPCLPNVTGLACDR-CADGYWNLVP 1073

  Fly   661 GPGCKLKCNCE----HGGECNHVTGQCQCLPGWTGSNCNESCPTDTYGQ--GCAQRCRC----VH 715
            |.||: .|:|:    ....|:.:||||.|..|:.|..|:| |..:.||.  |....|.|    ..
Human  1074 GRGCQ-SCDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSE-CQENYYGDPPGRCIPCDCNRAGTQ 1136

  Fly   716 HKVCRKADGMCICETGWSGTRCDEVCPEGFYGEHCMNTCACPSANFQCHAAHGCVCRSGYTGDNC 780
            ..:|....|||.|..|.||.|||. |..|...|  ..||      .|||...          |..
Human  1137 KPICDPDTGMCRCREGVSGQRCDR-CARGHSQE--FPTC------LQCHLCF----------DQW 1182

  Fly   781 DELIAS--------QRIADQSENSSRASVALTLVLMTLFACIIFAVFIYYRRRVSNLKTEIAHVH 837
            |..|:|        .|:|...|:...          ||..|  .|.|...|..||.::..:.|
Human  1183 DHTISSLSKAVQGLMRLAANMEDKRE----------TLPVC--EADFKDLRGNVSEIERILKH-- 1233

  Fly   838 YTHDTNPPSWPPNHNFDNPVYGMQAETRLLPNNMRSKMNNFDQRSTMSTDYGDDCNASGRVGSYS 902
                              ||:         |:....|:.::
Human  1234 ------------------PVF---------PSGKFLKVKDY------------------------ 1247

  Fly   903 INYNHDLLTKNLNADRTNPIVYNESLKEEHVYDEIKHK------------EGYKDPVKIYSKILF 955
                ||.:.:.:       :..||.||..:.:.::|..            |..::.:.:.|.:|
Human  1248 ----HDSVRRQI-------MQLNEQLKAVYEFQDLKDTIERAKNEADLLLEDLQEEIDLQSSVL- 1300

  Fly   956 PEDEYDHLDYSRPSTSQKPHYHRMNDAMLNINQDE---EKPSNVKN--MTVL 1002
                  :...:..|.:.|.:||..:.|...||:..   ...:|.:|  :|:|
Human  1301 ------NASIADSSENIKKYYHISSSAEKKINETSSTINTSANTRNDLLTIL 1346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	26..92	CDD:462204	20/99 (20%)
		EGF_CA	274..319	CDD:473889	17/50 (34%)
		gliding_CglD	<451..579	CDD:468178	34/140 (24%)
		DSL	567..609	CDD:473190	10/41 (24%)
LAMB4	XP_011514277.1	Laminin_N	28..263	CDD:459653
		EGF_Lam	264..320	CDD:238012	9/33 (27%)
		Laminin_EGF	332..382	CDD:395007	6/49 (12%)
		Laminin_EGF	395..452	CDD:395007	22/65 (34%)
		EGF_Lam	454..503	CDD:238012	15/49 (31%)
		EGF_Lam	505..549	CDD:238012	13/43 (30%)
		EGF_Lam	768..809	CDD:238012	15/41 (37%)
		Laminin_EGF	822..865	CDD:395007	12/44 (27%)
		EGF_Lam	862..909	CDD:238012	18/77 (23%)
		Laminin_EGF	970..>1012	CDD:395007	12/44 (27%)
		Laminin_EGF	1033..1077	CDD:395007	18/59 (31%)
		Laminin_EGF	1080..1128	CDD:395007	16/48 (33%)
		EGF_Lam	1127..>1165	CDD:238012	14/38 (37%)
		Mplasa_alph_rch	1254..>1714	CDD:275316	19/107 (18%)