DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drpr and FGFR2

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	XP_006717771.1	Gene:	FGFR2 / 2263	HGNCID:	3689	Length:	839	Species:	Homo sapiens

Alignment Length:	346	Identity:	65/346 - (18%)
Similarity:	115/346 - (33%)	Gaps:	118/346 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   747 GEHCMNTCACP--SANFQCHAAHGCVCRSGY----------TGDNCDELIASQRIADQSENSSRA 799
            ||:.....|.|  |..:.|.|:......:.|          :||:.|:...::....::.|:.||
Human   108 GEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 172

  Fly   800 SVALTLVLMTLFACIIFAVFIYYRRRVSNLKTEIAHVHYTHDTNPPSW--PPNHNFDNPVYGM-- 860
            .                    |:    :|.:.....:|.....|...:  |..   .||:..|
Human   173 P--------------------YW----TNTEKMEKRLHAVPAANTVKFRCPAG---GNPMPTMRW 210

  Fly   861 -------QAETRLLPNNMRSKMNNFDQRSTMSTDYGD-DCNASGRVGSYSINYNHD--------- 908
                   :.|.|:....:|::..:....|.:.:|.|: .|......||.:..|:.|
Human   211 LKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRP 275

  Fly   909 LLTKNLNADRTNPI---------VYNESLKEEHVYDEIKH--KEGYK-DPVKI-YSKILFPEDEY 960
            :|...|.|:.:..:         ||:::  :.|: ..|||  |.|.| .|..: |.|:|    ::
Human   276 ILQAGLPANASTVVGGDVEFVCKVYSDA--QPHI-QWIKHVEKNGSKYGPDGLPYLKVL----KH 333

  Fly   961 DHLDYSRPSTSQKPHYHRMNDAMLNINQDE--EKPSNVKN----------MTVLLNKPLPPTEPE 1013
            ..::.|.....          |:.|:.:.:  |....|.|          :|||..:..|..|.|
Human   334 SGINSSNAEVL----------ALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKE 388

  Fly  1014 PQHECFDNTNTNLDNVSTASP 1034
                            .||||
Human   389 ----------------ITASP 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395
		DSL	<479..518	CDD:302925
		DSL	<567..606	CDD:302925
FGFR2	XP_006717771.1	Ig1_FGFR	66..143	CDD:143174	8/34 (24%)
		IG_like	66..143	CDD:214653	8/34 (24%)
		Ig2_FGFR	183..267	CDD:143265	16/86 (19%)
		IG_like	282..376	CDD:214653	20/110 (18%)
		Ig3_FGFR	290..377	CDD:143175	20/103 (19%)
		PTKc_FGFR2	474..786	CDD:270679
		Pkinase_Tyr	499..775	CDD:285015
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900