DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drpr and FGFR3

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	XP_006713931.1	Gene:	FGFR3 / 2261	HGNCID:	3690	Length:	811	Species:	Homo sapiens

Alignment Length:	385	Identity:	81/385 - (21%)
Similarity:	117/385 - (30%)	Gaps:	139/385 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 GPACDINCPPGWYGRNCSMQCDCLNNAVCEPFSGDCECAKGYTGARCAD---ICPEGFFGANCSE 186
            |.|.:::|||...|                |. |.....|..||...::   :.|:.....|.|
Human    54 GDAVELSCPPPGGG----------------PM-GPTVWVKDGTGLVPSERVLVGPQRLQVLNAS- 100

  Fly   187 KCRCENGGKCHHVSGECQCAPGFT-GPLCDMRCPDGKHGAQCQQDCPC---QNDGKCQPE-TGAC 246
                      |..||...|....| ..||        |.:....|.|.   ..||:.:.| ||..
Human   101 ----------HEDSGAYSCRQRLTQRVLC--------HFSVRVTDAPSSGDDEDGEDEAEDTGVD 147

  Fly   247 MCNPGWT--------------GDVCANKCPVGSYGPGCQESCECYKGAPCHHIT----GQCECPP 293
            ...|.||              .:....:||..              |.|...|:    |:
Human   148 TGAPYWTRPERMDKKLLAVPAANTVRFRCPAA--------------GNPTPSISWLKNGR----- 193

  Fly   294 GYRGERCFDECQLNTYGFNCSMTCDCANDAMCDRANGTCICNPGWTGAK------CAER-----I 347
            .:|||......:|....::..|    .:....||.|.||:....:...:      ..||     |
Human   194 EFRGEHRIGGIKLRHQQWSLVM----ESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPI 254

  Fly   348 CEANKYGLDCNRTC--ECDMEHTDLCHPETGNCQCSIGWSSAQCTRPCTFLRYGPNCELTCNCKN 410
            .:|   ||..|:|.  ..|:|.           .|.: :|.||     ..:::..:.|:     |
Human   255 LQA---GLPANQTAVLGSDVEF-----------HCKV-YSDAQ-----PHIQWLKHVEV-----N 294

  Fly   411 GAKCSPVNGT--CLCAPGWRGPTCEESCEPGTFGQDCALRCDCQNGAKCEPETGQCLCTA 468
            |:|..| :||  ......|    ..||.|     .|..||.    ....|.:.|:.||.|
Human   295 GSKVGP-DGTPYVTVLKSW----ISESVE-----ADVRLRL----ANVSERDGGEYLCRA 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395	9/48 (19%)
		DSL	<479..518	CDD:302925
		DSL	<567..606	CDD:302925
FGFR3	XP_006713931.1	IGc2	53..110	CDD:197706	17/83 (20%)
		IG	54..125	CDD:214652	22/106 (21%)
		Ig2_FGFR	161..245	CDD:143265	16/106 (15%)
		IG_like	171..245	CDD:214653	16/96 (17%)
		IG_like	260..355	CDD:214653	27/117 (23%)
		Ig3_FGFR	268..356	CDD:143175	25/109 (23%)
		PKc_like	463..797	CDD:304357
		Pkinase_Tyr	476..752	CDD:285015
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900