DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drpr and Scarf2

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	XP_036015777.1	Gene:	Scarf2 / 224024	MGIID:	1858430	Length:	838	Species:	Mus musculus

Alignment Length:	656	Identity:	186/656 - (28%)
Similarity:	247/656 - (37%)	Gaps:	216/656 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 INCPPGW--YGRNCSMQ-CD----CLNNAVC-EPFSGDCECAKGYTGARCADICPEGFFGANCSE 186
            :.|..||  .|..|.:. |:    |..|.|| .|  |:|.|..||.||.|...||..|:|.:|.|
Mouse    54 LTCCAGWRQLGDECGIAVCEGNSTCSENEVCVRP--GECRCRHGYFGANCDTKCPRQFWGPDCKE 116

  Fly   187 KCRCENGGKCHHVSGECQCAPGFTGPLCDMRCPDGKHGAQCQQDCPCQNDGKCQPETGACMCNPG 251
            :|.|...|:|..|:|:|.|..             .:.||:|:..|.||: |.|.|.:|||.|.||
Mouse   117 RCSCHPHGQCEDVTGQCTCHA-------------RRWGARCEHACQCQH-GTCHPRSGACRCEPG 167

  Fly   252 WTGDVCANKCPVGSYGPGCQESCECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMT 316
            |                                                        :|..|:..
Mouse   168 W--------------------------------------------------------WGAQCASA 176

  Fly   317 CDCANDAMCDRANGTCICNPGWTGAKCAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCS 381
            |.|:..:.||...|.|:|:.||              :|..||..|.|   ::..|..::|.|||
Mouse   177 CYCSATSRCDPQTGACLCHVGW--------------WGRSCNNQCAC---NSSPCEQQSGRCQC- 223

  Fly   382 IGWSSAQCTRPCTFLRYGPNCELTCNCKNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQDCA 446
                     |...|   |..|:..|.|.:| :|.||:|||.|.||:||..|.|.|..|.:|..|.
Mouse   224 ---------RERMF---GARCDRYCQCSHG-RCHPVDGTCACDPGYRGKYCREPCPAGFYGPGCR 275

  Fly   447 LRC-DCQNGAKCEPETGQCL-CTAGWKNIKCDRPCDLNHFGQDCAKVC-DCHNNAACNPQNGSCT 508
            .|| .|:....|....|:|| |..||...|||:||....:|:.|...| .|.:..|||...|.||
Mouse   276 RRCGQCKGQQPCTVVEGRCLTCEPGWNGTKCDQPCATGFYGEGCGHRCPPCRDGHACNHVTGKCT 340

  Fly   509 -CAAGWTGERCERKCDTGKFGHDCAQKC-QCDFNNSLACDATNGRCVCKQDWGGVHCETNCRSGY 571
             |.|||.|:|||.||..|.:|.|||..| .|   .|..||..:|||:|.....|.||...|.:|.
Mouse   341 HCNAGWIGDRCETKCSNGTYGEDCAFVCSDC---GSGHCDFQSGRCLCSPGVHGPHCNVTCPAGL 402

  Fly   572 YGENCDKVCRCLNNSSCDPDSGNCI----------------------------CSAGWTGADCA- 607
            :|.:|.:.|.| :..||||.:|.|.                            |.....|.|.|
Mouse   403 HGVDCAQACSC-HEESCDPVTGACHLETNQRKGVMGAGALLTLLLGLLLSLLGCCCACRGKDSAR 466

  Fly   608 --EPC----------PPGFYG------MEC------KERCPEILHGNKSCDHITGEILCRTGYIG 648
              .||          |..|.|      |:.      :::.|:::..:...|:.
Mouse   467 RPRPCRELTLGRKKAPQRFCGSFSRISMKLPRIPLRRQKLPKVVVAHHDLDNT------------ 519

  Fly   649 LTCE--HPCPAGLYGPGCKLKCNCEHGGECNHVTGQCQCLPGWTGSNCNESCPTDTYGQGCAQRC 711
            |.|.  .| |:||..|.                       |.|:......|  .||..:|...
Mouse   520 LNCSFLDP-PSGLEQPS-----------------------PSWSSRASFSS--FDTTDEGPVY-- 556

  Fly   712 RCVHHK 717
             ||.|:
Mouse   557 -CVPHE 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395	3/44 (7%)
		DSL	<479..518	CDD:302925	16/40 (40%)
		DSL	<567..606	CDD:302925	14/66 (21%)
Scarf2	XP_036015777.1	exchanger_TraA	<74..431	CDD:411343	152/463 (33%)
		PHA03307	526..>836	CDD:223039	14/65 (22%)
		PHA03247	<683..838	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810