DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drpr and Tie1

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_035717.2	Gene:	Tie1 / 21846	MGIID:	99906	Length:	1134	Species:	Mus musculus

Alignment Length:	218	Identity:	61/218 - (27%)
Similarity:	78/218 - (35%)	Gaps:	87/218 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 CPVGSYGPGCQESCE-CYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCDCANDAM 324
            |..|.:||||.:.|. |..|..||...|:|.||||:.|.||
Mouse   213 CGAGRWGPGCVKDCPGCLHGGVCHDHDGECVCPPGFTGTRC------------------------ 253

  Fly   325 CDRANGTCICNPGWTGAKCAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSAQC 389
                                |:.|...::|..|...|           |.|..|
Mouse   254 --------------------EQACREGRFGQSCQEQC-----------PGTAGC----------- 276

  Fly   390 TRPCTFLRYGPNCELTCNCKNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQNG 454
             |..||                  |.|....|.|..||||..|:|:|.||.||.||.|:|.||||
Mouse   277 -RGLTF------------------CLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRLQCQCQNG 322

  Fly   455 AKCEPETGQCLCTAGWKNIKCDR 477
            ..|:..:| |:|.:||..:.|::
Mouse   323 GTCDRFSG-CVCPSGWHGVHCEK 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395	14/45 (31%)
		DSL	<479..518	CDD:302925
		DSL	<567..606	CDD:302925
Tie1	NP_035717.2	ig	127..208	CDD:278476
		IG_like	131..210	CDD:214653
		EGF_Lam	225..263	CDD:238012	16/81 (20%)
		EGF_CA	312..343	CDD:238011	14/31 (45%)
		ig	353..439	CDD:278476
		IG	367..441	CDD:214652
		fn3	447..518	CDD:278470
		fn3	546..628	CDD:278470
		FN3	640..732	CDD:238020
		PTKc_Tie1	832..1128	CDD:270671
		TyrKc	835..1103	CDD:197581
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900