Protein Alignment drpr and Megf11

DIOPT Version :10

• Sequence 1: NP_001261276.1
• Gene: drpr / 38218
• FlyBaseID: FBgn0027594
• Length: 1042
• Species: Drosophila melanogaster
• Sequence 2: NP_001395541.1
• Gene: Megf11 / 214058
• MGIID: 1920951
• Length: 1138
• Species: Mus musculus
• Alignment Length: 1125
• Identity: 382/1125 - (33%)
• Similarity: 534/1125 - (47%)
• Gaps: 137/1125 - (12%)

  Fly     1 MLP--VILIACLAQLVLAQADLKDLDGPNICKRRELYNVDVVYTELQSFQERGSTWCVTFPP--R 61
            |.|  |.|:..|.|..||    .:.:.||:|...|.|.|.|..:....|.:...|.|.....  :
Mouse     1 MAPSAVGLLVFLLQAALA----LNPEDPNVCSHWESYAVTVQESYAHPFDQIYYTRCADILNWFK 61

  Fly    62 CSTYRIKHRVVNK--TKTIAKNRIVRDCCDGYIASAGECVPHCSEPCQHGRCISPEKCKCDHGYG 124
            |:.:||.::...:  .:|:.:.|  ..||.||..:...|:|.|:|.|.||||:||:.|.|:.|:|
Mouse    62 CTRHRISYKTAYRRGLRTMYRRR--SQCCPGYYENGDFCIPLCTEECMHGRCVSPDTCHCEPGWG 124

  Fly   125 GPACDINCPPGWYGRNCSMQCDCLNNAVCEPFSGDCECAKGYTGARCADICPEGFFGANCSEKCR 189
            ||.|...|....:|.:||.:|.|.|.|:|.|.:|.|.||.|:.|.||.::|..|..|..|...|:
Mouse   125 GPDCSSGCDSEHWGPHCSNRCQCQNGALCNPITGACVCAPGFRGWRCEELCAPGTHGKGCQLLCQ 189

  Fly   190 CENGGKCHHVSGECQCAPGFTGPLCDMRCPDGKHGAQCQQDCPCQNDGKCQPETGACMCNPGWTG 254
            |.:|..|...:|||.||||:||..|:..||.|.|||.|:..|||||.|.|...||.|.|.|||||
Mouse   190 CHHGASCDPRTGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTG 254

  Fly   255 DVCANKCPVGSYGPGCQESCECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCDC 319
            .|||..||.|::|..|.:.|.|:.|..|.|:||||.|..||.|:||.:||...|:||.||..|||
Mouse   255 AVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGTFGFLCSQRCDC 319

  Fly   320 ANDAMCDRANGTCICNPGWTGAKCAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIGW 384
            .|...|..|.|.|.|.||:.|..|.||:|....:|..|...|.||.|:|..|||.||.|.|..||
Mouse   320 HNGGQCSPATGACECEPGYKGPSCQERLCPEGLHGPGCTLPCPCDTENTISCHPVTGACTCQPGW 384

  Fly   385 SSAQCTRPCTFLRYGPNCELTCNCKNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQDCALRC 449
            |...|...|....||..|:|.|.|:|||.|..:.|:|.||||:.|..|...|..||:|.:|:..|
Mouse   385 SGHYCNESCPAGYYGNGCQLPCTCQNGADCHSITGSCTCAPGFMGEVCAVPCAAGTYGPNCSSVC 449

  Fly   450 DCQNGAKCEPETGQCLCTAGWKNIKCDRPCDLNHFGQDCAKVCDCHNNAACNPQNGSCTCAAGWT 514
            .|.||..|.|..|.|.|..||:.:.|..||....:|.:|.:.|.|.|.|||:|.:|||.|..||.
Mouse   450 SCSNGGTCSPVDGSCTCREGWQGLDCSLPCPSGTWGLNCNETCICANGAACSPFDGSCACTPGWL 514

  Fly   515 GERCERKCDTGKFGHDCAQKCQCDFNNSLACDATNGRCVCKQDWGGVHCETNCRSGYYGENCDKV 579
            |:.||..|..|.||.:|::.|.|  :::..||...|.|.|...|.|:.|::.|..|.:|.||...
Mouse   515 GDSCELPCPDGTFGLNCSEHCDC--SHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVS 577

  Fly   580 CRCLNNSSCDPDSGNCICSAGWTGADCAEPCPPGFYGMECKERCPEILHGNKSCDHITGEILCRT 644
            |.|.|..||.|:.|:|.|:.|:.|..|...|||||||..|.:.||..:|....|.||:|...|..
Mouse   578 CSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSRGPCHHISGICECLP 642

  Fly   645 GYIGLTCEHPCPAGLYGPGCKLKCNCEHGGECNHVTGQCQCLPGWTGSNCNESCPTDTYGQGCAQ 709
            |:.|..|...|..|.:|..|...|:|.:.|.|:.:.|.|||.|||.|.:|:::||:..:|..|..
Mouse   643 GFSGALCNQVCAGGHFGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPSGFWGSACFH 707

  Fly   710 RCRCVHHKVCRKADGMCICETGWSGTRCDEVCPEGFYGEHCMNTCACPSANFQCHAAHGCVCRSG 774
            .|.|.:...|...||.|.|..||:|..|.:.||..|:|:.|.:.|.|.:.....|....|.||:|
Mouse   708 TCSCHNGASCSAEDGACHCTPGWTGLFCTQRCPSAFFGKDCGHICQCQNGASCDHITGKCTCRTG 772

  Fly   775 YTGDNCDELIA-------SQRIADQSENSS----------------------------------- 797
            ::|.:|::..|       .|::.:...|::
Mouse   773 FSGRHCEQRCAPGTFGYGCQQLCECMNNATCDHVTGTCYCSPGFKGIRCDQAALMMDELNPYTKI 837

  Fly   798 -------RASV-ALT-LVLMTLFACIIFAVFIYYRRRVSNLKTEIA-HVHYT---------HDTN 843
                   |.|| |:| :||:.....::..:|.:.|||......::| .|.||         :..:
Mouse   838 SPALGAERHSVGAVTGIVLLLFLVVVLLGLFAWRRRRQKEKGRDLAPRVSYTPAMRMTSTDYSLS 902

  Fly   844 PPSWPPNHN--FDNPVY---------GMQAETRLLPNNMRSKMNN--FDQRSTMSTDYGDDCNAS 895
            ..|...:|.  |.|..|         ..||.|  |..|..:|::|  .|:.:...|.|
Mouse   903 DLSQSSSHAQCFSNASYHTLACGGPATSQAST--LDRNSPTKLSNKSLDRDTAGWTPY------- 958

  Fly   896 GRVGSYSINYNHDLLTKNLNADRTNPIVYNESLKEEHVYDEIKHKEGYKDPVKIYSKILFPEDEY 960
                ||....:.......|.| |..|         |..|.|::|...:.:|   :|......|..
Mouse   959 ----SYVNVLDSHFQISALEA-RYPP---------EDFYIELRHLSRHAEP---HSPGTCGMDRR 1006

  Fly   961 DHL--------DYSRPSTSQKPHYHRMNDAMLNINQDEEKPSNVKNMTVLLNKPLPPTE----PE 1013
            .:.        ||.:.|.        .:.:..::|..|...:.:|:..:|..| ||.:.    ..
Mouse  1007 QNTYIMDKGFKDYMKESV--------CSSSTCSLNSSENPYATIKDPPILTCK-LPESSYVEMKS 1062

  Fly  1014 PQHECFDNTNTNLDNVSTAS 1033
            |.|  ..:..|::.::||::
Mouse  1063 PVH--LGSPYTDVPSLSTSN 1080

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	26..92	CDD:462204	18/69 (26%)
		EGF_CA	274..319	CDD:473889	23/44 (52%)
		gliding_CglD	<451..579	CDD:468178	51/127 (40%)
		DSL	567..609	CDD:473190	17/41 (41%)
Megf11	NP_001395541.1	EMI	24..93	CDD:462204	19/70 (27%)
		EGF_CA	188..233	CDD:473889	22/44 (50%)
		EGF_CA	274..319	CDD:473889	23/44 (52%)