DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drpr and MEGF6

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	XP_011539187.1	Gene:	MEGF6 / 1953	HGNCID:	3232	Length:	1603	Species:	Homo sapiens

Alignment Length:	900	Identity:	311/900 - (34%)
Similarity:	415/900 - (46%)	Gaps:	167/900 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DLDG--PNICKRRELYNVDVVYTEL-QSFQERGSTWCVTFPPRCSTYRIKHRVVNKTKTIAKNRI 83
            ||||  |.:   |.|.::.|:..|| |.||:..    |......:..|.:|       |:.:..:
Human   522 DLDGELPFV---RPLPHIAVLQDELPQLFQDDD----VGADEEEAELRGEH-------TLTEKFV 572

  Fly    84 VRDCCDGYIASAGECVPHCSEPCQHGRC-ISPEKCKCDHGYGGPACDINCPPGWYGRNCSMQCDC 147
            ..|...|:     :|...|.:....|.| :..:.|.|..|:.|..|:..|||..:|:|||..|.|
Human   573 CLDDSFGH-----DCSLTCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSC 632

  Fly   148 LNNAVCEPFSGDCECAKGYTGARCADICPEGFFGANCSEKCRCENGGKCHHVSGECQCAPGFTGP 212
            .|...|:..:|.|.|..|.:|..|.|.||:|::|.:|.:||.|.|.|:||.:.|.|.|.||..|.
Human   633 QNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGR 697

  Fly   213 LCDMRCPDGKHGAQCQQDCPC---------QNDGKCQPETG------------------------ 244
            .|.:.||....|..|.::|.|         :.||.|..:.|
Human   698 FCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACT 762

  Fly   245 -----AC---------MCNPGWTGDVCANKCPVGSYGPGCQESCECYKGAPCHHITGQCECPPGY 295
                 ||         .|..|:.|:.|..:||||::|..|..||.| .|||||.:||||.||||.
Human   763 CPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSC-GGAPCHGVTGQCRCPPGR 826

  Fly   296 RGERCFDECQLNTYGFNCSMTCD-CANDAMCDRANGTCICNPGWTGAKCAERICEANKYGLDCNR 359
            .||.|..:|....:|..|...|. |.:.|.||...|.|:|.||:.|::|.: :|.|..||..|..
Human   827 TGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQD-VCPAGWYGPSCQT 890

  Fly   360 TCECDME-HTDLCHPETGNCQCSIGWSSAQCTRPCTFLRYGPNCELTCNCKNG-AKCSPVNGTCL 422
            .|.|..: |   |||.||:|.|:.||:...|.|.|....:||:|...|||..| ..|..::|.||
Human   891 RCSCANDGH---CHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCL 952

  Fly   423 CAPGWRGPTCEESCEPGTFGQDCALRCDCQNGAKCEPETGQCLCTAGWKNIKCDRPCDLNHFGQD 487
            |..|:.||.||:.|..|.||..|..||.||:||.|:..:|.|.|.|||:...|:..|....||.|
Human   953 CEAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGLD 1017

  Fly   488 CAKVCDCHNNAACNPQNGSCTCAAGWTGERCERKCDTGKFGHDCAQKCQCDFNNSLACDATNGRC 552
            |...|:|...|||:..||||.|.||..|.||...|....:||:|:|.|.| ||.: :||..:|:|
Human  1018 CRSACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACAC-FNGA-SCDPVHGQC 1080

  Fly   553 VCKQDWGGVHCETNCRSGYYGEN------------CDKV-------------------------- 579
            .|...|.|..|...|.:|.||:|            ||.|
Human  1081 HCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRA 1145

  Fly   580 -CR----CLNNSSCDPDSGNCICSAGWTGADCAEP------------------------------ 609
             ||    |||...|||.:|.|:|.|||||..|..|
Human  1146 GCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGACR 1210

  Fly   610 CPPGFYGMECKERCPEILHG------------NKSCDHITGEILCRTGYIGLTCEHPCPAGLYGP 662
            |||||.|..|::.||....|            |.:|...||...|..||.|.:|:..||.|.|||
Human  1211 CPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGP 1275

  Fly   663 GCKLKCNCEHGGECNHVTGQCQCLPGWTGSNCNESCPTDTYGQGCAQRCRCVHHKVCRKADGMCI 727
            ||:..|.|.:||.|:..||.|:|..|:.|::||.:||...:|..|...|.|.....|....|.|:
Human  1276 GCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCL 1340

  Fly   728 CETGWSGTRCDEVCPEGFYGEHCMNTCACPSANFQCHAAHG-CVCRSGYTGDNCD 781
            |..|.:|.||:..||:..:|..|.:||:|.:... |||::| |.|..|:||.:|:
Human  1341 CPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGL-CHASNGSCSCGLGWTGRHCE 1394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877	14/65 (22%)
		EGF_CA	274..319	CDD:304395	22/45 (49%)
		DSL	<479..518	CDD:302925	18/38 (47%)
		DSL	<567..606	CDD:302925	24/81 (30%)
MEGF6	XP_011539187.1	EMI	108..176	CDD:284877
		vWFA	<215..261	CDD:294047
		FXa_inhibition	268..304	CDD:291342
		vWFA	<342..384	CDD:294047
		FXa_inhibition	397..432	CDD:291342
		vWFA	<432..469	CDD:294047
		vWFA	<472..511	CDD:294047
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	119	1.000	Domainoid score	I5794
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24035
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.910